Sweet syndrome as a cutaneous manifestation in a patient with Erysipelothrix rhusiopathiae bacteremia: A case report

Kiratikanon, Salin; Thongwitokomarn, Harit; Chaiwarith, Romanee; Salee, Parichat; Mahanupab, Pongsak; Jamjanya, Sirinda; Chieosilapatham, Panjit; Prinyaroj, Nayanunt; Tovanabutra, Napatra; Chiewchanvit, Siri; Chuamanochan, Mati

doi:10.1016/j.idcr.2021.e01148

Cited by 5 publications

(1 citation statement)

References 10 publications

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“…Human infections are associated with exposure to animals and usually infect individuals belonging to certain occupational groups, such as veterinarians, butchers, farmers, and fishermen [4][5][6][7]. Erysipeloid typically manifests on the face or legs as a raised, well-demarcated, bright red rash [8]. Three forms of erysipeloid have been described, as follows: the localised and the generalised forms, which are cutaneous, and the septicaemic form, [9] associated with endocarditis in 90% of cases [9,10].…”

Section: Introductionmentioning

confidence: 99%

Bloodstream Infection Caused by Erysipelothrix rhusiopathiae in an Immunocompetent Patient

Mileto,

Merla,

Corbella

et al. 2024

Microorganisms

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Erysipelothrix rhusiopathiae is a facultative anaerobe Gram-positive bacillus, which is considered a zoonotic pathogen. E. rhusiopathiae causes erysipeloid, mainly in occupational groups such as veterinarians, slaughterhouse workers, farmers, and fishermen. Two cutaneous forms (localised and generalised) and a septicaemic form have been described. Here, we report the isolation of a strain of E. rhusiopathiae from a 56-year-old immunocompetent obese male admitted to Fondazione IRCCS Policlinico San Matteo Pavia (Italy). Blood cultures were collected and Gram-positive bacilli were observed. E. rhusiopathiae grew and was identified. Antimicrobial susceptibility tests were performed and interpreted with EUCAST breakpoints (PK-PD). The strain was susceptible to all the antibiotics tested, while it was intrinsically resistant to vancomycin. The clinical diagnosis of E. rhusiopathiae can be challenging, due to the broad spectrum of symptoms and potential side effects, including serious systemic infections such as heart diseases. In the case described, bacteraemia caused by E. rhusiopathiae was detected in a immunocompetent patient. Bacteraemia caused by E. rhusiopathiae is rare in immunocompetent people and blood cultures were proven to be essential for the diagnosis and underdiagnosis of this pathogen, which is possible due to its resemblance to other clinical manifestations.

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Section: Introductionmentioning

confidence: 99%

Bloodstream Infection Caused by Erysipelothrix rhusiopathiae in an Immunocompetent Patient

Mileto,

Merla,

Corbella

et al. 2024

Microorganisms

View full text Add to dashboard Cite

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New Practical Aspects of Sweet Syndrome

et al. 2022

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Sweet syndrome (SS), or acute febrile neutrophilic dermatosis, is an inflammatory, non-infectious skin reaction characterized clinically by tender, erythematous papules/plaques/pustules/nodules commonly appearing on the upper limbs, trunk, and head and neck; histologically, SS is characterized by dense neutrophilic infiltrate in the dermis. SS is accompanied by fever; an elevation of inflammatory markers (e.g., erythrocyte sedimentation rate, C reactive protein) in serum may also be observed. Although most cases of SS are idiopathic, SS also occurs in the setting of malignancy or following administration of an associated drug. SS has also been reported in association with pregnancy and a burgeoning list of infectious (most commonly upper respiratory tract infections) and inflammatory diseases; likewise, the litany of possible iatrogenic triggers has also grown. Over the past several years, a wider spectrum of SS presentation has been realized, with several reports highlighting novel clinical and histological variants. Corticosteroids continue to be efficacious first-line therapy for the majority of patients with SS, although novel steroid-sparing agents have been recently added to the therapeutic armamentarium against refractory SS. New mechanisms of SS induction have also been recognized, although the precise etiology of SS still remains elusive. Here, we catalogue the various clinical and histological presentations of SS, summarize recently reported disease associations and iatrogenic triggers, and review treatment options. We also attempt to frame the findings of this review in the context of established and emerging paradigms of SS pathogenesis.

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