Sweet Syndrome Associated With New-Onset Systemic Lupus Erythematosus in a 25-Year-Old Man

Fernandes, Neil F.; Castelo‐Soccio, Leslie; Kim, Ellen J.; Werth, Victoria P.

doi:10.1001/archdermatol.2009.82

Cited by 7 publications

(3 citation statements)

References 8 publications

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“…Concurrent Sweet's disease and SLE are exceedingly rare. Only two other papers reported Sweet's syndrome as an initial presentation in adult SLE [ 6 , 8 ]. Our Case 1 is the third.…”

Section: Discussionmentioning

confidence: 99%

Association of Sweet's Syndrome and Systemic Lupus Erythematosus

Barton

Pincus

Yazdany

et al. 2011

Case Reports in Rheumatology

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Sweet's syndrome is an acute febrile neutrophilic dermatosis which usually presents as an idiopathic disorder but can also be drug induced, associated with hematopoetic malignancies and myelodysplastic disorders, and more, infrequently, observed in autoimmune disorders. Sweet's syndrome has been reported in three cases of neonatal lupus, three cases of hydralazine-induced lupus in adults, and in nine pediatric and adult systemic lupus erythematosus (SLE) patients. We describe three additional adult cases of Sweet's associated with SLE and provide a focused review on nondrug-induced, nonneonatal SLE and Sweet's. In two of three new cases, as in the majority of prior cases, the skin rash of Sweet's paralleled underlying SLE disease activity. The pathogenesis of Sweet's remains elusive, but evidence suggests that cytokine dysregulation may be central to the clinical and pathological changes in this condition, as well as in SLE. Further research is needed to define the exact relationship between the two conditions.

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“…Concurrent Sweet's disease and SLE are exceedingly rare. Only two other papers reported Sweet's syndrome as an initial presentation in adult SLE [ 6 , 8 ]. Our Case 1 is the third.…”

Section: Discussionmentioning

confidence: 99%

Association of Sweet's Syndrome and Systemic Lupus Erythematosus

Barton

Pincus

Yazdany

et al. 2011

Case Reports in Rheumatology

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“…Since then, several cases of SLE with SS have been reported, of which some were drug induced [23]. To our knowledge, there have been only two cases of SS as the initial presentation of SLE reported in male patients in the literature [24,25]. Though both SLE and classical SS manifest predominantly in females, this is the third such case to be reported in a male.…”

Section: Discussionmentioning

confidence: 95%

Systemic Lupus Erythematosus presenting as Sweet Syndrome: A Case Report

Rajasuriya

Mujaheith

2023

J. Postgrad. Inst. Med.

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“…Only three other papers reported Sweet syndrome as an initial presentation in adult SLE. [7][8][9] Sweet syndrome is an acute febrile neutrophilic dermatosis which often presents in idiopathic fashion can also be drug induced, associated with malignancy, or connective tissue diseases. 10 It is shown in Table 1.…”

Section: Discussionmentioning

confidence: 99%

Sweet syndrome: a sweet disease with a bitter diagnosis

et al. 2018

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Sweet syndrome is an acute febrile neutrophilic dermatosis first described by Robert Douglas Sweet in 1964. Sweet syndrome presents in three clinical settings: classical (or idiopathic), malignancy-associated, and drug-induced. It has been associated with hematopoietic malignancies and myelodysplastic disorders. A-28-years married woman presented to us with chief complaints of Fever and Multiple swellings over the body since 2 months. At presentation she has Pallor; venous hum present. Multiple, tender, erythematous subcutaneous swellings, firm in consistency noted in both forearms. Skin over the swellings is pinchable; superficial skin is normal. Sweet syndrome can occasionally cause an intense systemic response involving the lungs, liver and musculoskeletal system. The skin lesions in Sweet syndrome typically start as erythematous papules, plaques, and nodules. The lesions can take on pseudovesicular or pseudopustular appearance, and sometimes fully formed vesicles or pustules develop. The lesions can be subcutaneous mimicking erythema nodosum which can’t be differentiated unless a biopsy is taken. Because the diagnosis of Sweet syndrome can be challenging, particularly when associated with other connective tissue disorders such as SLE, a set of diagnostic criteria were proposed initially by Su and Liu and then revised by Von den Driesch. The diagnosis is based upon the presence of two major and two of the four minor criteria. Concurrent Sweet syndrome and SLE are exceedingly rare. Twelve patients with both Sweet syndrome and systemic lupus erythematosus (SLE) have been previously reported. We report a case of sweet syndrome associated with SLE diagnosed in our hospital. In our patient, diagnostic criteria are satisfied for Sweet syndrome as well as for SLE (ACR criteria-patient had polyarthralgia, anemia, thrombocytopenia, ANA and Ds DNA positive. Four out of 11 are fulfilled for SLE). Patient responded to corticosteroids.

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Sweet Syndrome Associated With New-Onset Systemic Lupus Erythematosus in a 25-Year-Old Man

Cited by 7 publications

References 8 publications

Association of Sweet's Syndrome and Systemic Lupus Erythematosus

Association of Sweet's Syndrome and Systemic Lupus Erythematosus

Systemic Lupus Erythematosus presenting as Sweet Syndrome: A Case Report

Sweet syndrome: a sweet disease with a bitter diagnosis

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