Sweet taste-induced analgesia: an fMRI study

Kakeda, Takahiro; Ogino, Yuichi; Moriya, Fumio; Saito, Shigeru

doi:10.1097/wnr.0b013e3283383df5

Cited by 42 publications

(40 citation statements)

References 26 publications

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“…In fact, there is considerable evidence that sucrose or other hedonic substances can provide analgesia, including inhibition of spontaneous behaviors in the formalin test in rodents and reduction of the response to acute painful stimuli in psychophysical studies in humans [4; 16; 21; 33]. Therefore, in the next experiment we asked whether the enhanced sucrose consumption that we observed was, in fact, driven by DPI-induced pain.…”

Section: Resultsmentioning

confidence: 87%

Paradoxical surrogate markers of dental injury-induced pain in the mouse

Gibbs¹,

Urban

Basbaum

2013

Pain

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Section: Resultsmentioning

confidence: 87%

Paradoxical surrogate markers of dental injury-induced pain in the mouse

Gibbs¹,

Urban

Basbaum

2013

Pain

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“…However, previous studies reported that sweet taste has an analgesic effect. 1,39 For example, an experimental study showed that holding sucrose in the mouth was significantly associated with a 35% prolongation of children's threshold times compared to holding water in their mouths while undergoing the cold pressor test. 1 Furthermore, sugar is hypothesized to potentially be an addictive substance, and palatable foods high in sugar are often consumed in a way similar to the way drugs are abused.…”

Section: Discussionmentioning

confidence: 99%

Problem Behavior, Victimization, and Soda Intake in High School Students

Park

Blanck²,

Sherry³

et al. 2013

Am J Hlth Behav

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Objective-To examine associations of problem behaviors and victimization with nondiet soda intake among a national sample of 16,188 US high school students.Methods-We used the 2009 national Youth Risk Behavior Survey. The outcome measure was daily nondiet soda intake.Results-Smoking, having any sex partners, not always wearing a seat belt, being bullied/ threatened/injured on school property, and being physically hurt by their boyfriend/girlfriend were significantly associated with daily nondiet soda intake after adjustment for age, sex, race/ethnicity, and weight status.Conclusions-Our findings suggest a need to examine why nondiet soda intake is associated with these behaviors to understand potential mechanisms. Keywordssoda; adolescents; problem behaviors; being victimized; YRBS Detrimental behaviors or being victimized might be associated with soda intake because evidence suggests that for children, sweet taste has analgesic properties, 1 and the stronger their sweet preference, the greater its analgesic effect on them. 2 Moreover, palatable foods (ie, foods high in sugar or fat) and addictive drugs stimulate some of the same neural systems in the brain (eg, the reward pathway) that process behavior reinforcement (eg, dopamine and opioids). [3][4][5] For example, a study reported that youth with a family history of alcoholism and positive depressive symptoms preferred sweeter solutions. 6 One experimental study reported that smokers had significantly higher liking of sweets than did never smokers. 7 Although it is speculative, it is also plausible that unhealthy behaviors (eg, substance use) could be associated with other secondary unhealthy dietary behaviors such as Correspondence: Dr Park; spark3@cdc.gov. Human Subjects StatementStudent participation in the survey was anonymous and voluntary, and local parental permission procedures were followed. The CDC's institutional review board granted approval for the national YRBS. Conflict of Interest StatementThe authors declare that there are no conflicts of interest.Abstract was presented at the Obesity Society Conference in 2011. HHS Public Access Author Manuscript Author ManuscriptAuthor Manuscript Author Manuscript high sugar intake through the consumption of calorically sweetened beverages. Calorically sweetened beverages include, but are not limited to, soft drinks (soda or pop), fruit drinks, sports drinks, energy drinks, tea and coffee drinks, sweetened milk, and any other beverages to which sugars have been added. 8 Previous studies that investigated the association between calorically sweetened beverages and problem behaviors, however, had inconsistent findings. 9,10 For instance, Miller reported that problem behaviors and substance use (eg, sexual risk taking, fighting, seat-belt omission, marijuana use, smoking, and alcohol use) were associated with increased frequency of energy drink intake among college students. 9 Another cross-sectional study with a relatively small convenience sample of 145 US adolescents attending alternative high scho...

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“…The histamine level increases in the PP state, and it has been shown to have an analgesic effect via the H3 receptor [8][9][10]. Recently, sweet taste-induced analgesia was demonstrated in humans by doing a functional MRI [11]. The decreased pain sensitivity which is produced by the above phenomena may lead to a decrease in the CVR in the ½ an hours post-prandial state.…”

Section: Discussionmentioning

confidence: 99%

The Stress-Induced Cardiovascular Reactivity in the Fasting and Fed States of Healthy Young Indian Males

Saxena

Gaurav²,

Kumar³

et al. 2013

JCDR

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Background and Objectives: Low blood glucose levels have been associated with a hostile behaviour. The individuals who show aggressiveness and hostility are more likely to develop hypertension and cardiac diseases. The future hypertension has been linked with a high cardiovascular reactivity to stress. We have investigated the association of the blood glucose levels with the Cardio Vascular Reactivity (CVR) to stress. Methods:Forty six volunteers were subjected to stress (which was induced by the cold pressor task) in the fasting state and again, half an hour after the ingestion of 75 grams of glucose. The CVR in both conditions was compared in terms of an increase in the heart rate and the blood pressure. Results:The resting pulse was lower and the blood pressure was higher in the fasting condition, as compared to the values which were obtained in the ½ hour post-prandial condition. The CVR to stress was significantly higher in the fasting condition. Interpretation and Conclusion:The increased resting heart rate and the decreased resting blood pressure in the ½ hourPost-Prandial (PP) condition was due to the higher levels of histamine in the post-prandial state. Low blood glucose levels are associated with a higher CVR to stress. This suggests that the persons are prone to develop future hypertension, those with frank hypertension, and the chronic pain sufferers should avoid prolonged fasts, in order to lower their CVR to the stress stimuli which are encountered in the daily life.

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Sweet taste-induced analgesia: an fMRI study

Cited by 42 publications

References 26 publications

Paradoxical surrogate markers of dental injury-induced pain in the mouse

Paradoxical surrogate markers of dental injury-induced pain in the mouse

Problem Behavior, Victimization, and Soda Intake in High School Students

The Stress-Induced Cardiovascular Reactivity in the Fasting and Fed States of Healthy Young Indian Males

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