Sweetened beverages are associated with a higher risk of differentiated thyroid cancer in the EPIC cohort: a dietary pattern approach

Zamora-Ros, Raúl; Cayssials, Valerie; Clèries, Ramón; Torrents, Maria; Byrnes, Graham; Weiderpass, Elisabete; Sandström, Maria; Almquist, Martin; Boutron‐Ruault, Marie‐Christine; Tjønneland, Anne; Kyrø, Cecilie; Katzke, Verena; Cornet, Charlotte Le; Masala, Giovanna; Iannuzzo, Gabriella; Tumino, Rosario; Milani, Lorenzo; Skeie, Guri; Ubago‐Guisado, Esther; Amiano, Pilar; Chirlaque, María-Dolores; Ardanáz, Eva; Janzi, Suzanne; Eriksson, Linda; Freisling, Heinz; Heath, Alicia K.; Rinaldi, Sabina; Agudo, Antonio

doi:10.1007/s00394-022-02953-5

Cited by 6 publications

(6 citation statements)

References 40 publications

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“…Table 1 provides a summary of the study characteristics. The 14 articles including 17 cohort studies comprised a total of 34,050 cancer cases occurring in 2,821,922 participants [ 35 , 36 , 37 , 38 , 39 , 42 , 43 , 44 , 48 , 59 , 60 , 61 , 62 , 63 ]. Seven cohorts reported the association between ASB intake and the risk of more than one type of cancer.…”

Section: Resultsmentioning

confidence: 99%

“… Forest plot of artificially sweetened beverage (ASB) intake and risk of cancer [ 35 , 36 , 37 , 38 , 39 , 42 , 43 , 44 , 48 , 59 , 60 , 61 , 62 , 63 ]. Dots indicate adjusted RR s by comparing the highest with the lowest categories of intake, and diamonds indicate the pooled RR s. The size of the shaded square is proportional to the percentage weight of each study, and horizontal lines indicate 95% CIs.…”

Section: Figurementioning

confidence: 99%

“…However, that meta-analysis used data from both prospective and retrospective studies, which increased the possibility of recall or selection bias. Meanwhile, several cohort studies [ 38 , 41 , 42 , 43 , 44 ] were published recently. Furthermore, the potential dose–response relationship between ASB intake and cancer risk has not been explored before.…”

Section: Introductionmentioning

confidence: 99%

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Artificially Sweetened Beverage Consumption and Cancer Risk: A Comprehensive Dose–Response Meta-Analysis of Prospective Studies

Yin

Wang

et al. 2022

Nutrients

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The impact of artificially sweetened beverages (ASBs), alternatives to sugar-sweetened beverages, on cancer incidence remains controversial. We conducted a meta-analysis of prospective studies to assess the association of daily ASB intake with cancer risk. A systematic search was performed between January 1967 and September 2022. Risk ratios (RR) or hazard ratios (HR) were extracted and pooled. The Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) approach was used for the assessment of the certainty of evidence. The study was registered at PROSPERO (CRD42022312171). Overall, 14 articles with 17 cohorts were included. There was no significant association between daily ASB consumption and risk of overall cancer (highest versus lowest category: n = 17, RR = 1.03, 95% CI: 0.96–1.11, p = 0.407). For site-specific cancer analysis, the risk of non-lymphoid leukemia was elevated with high ASB intake (n = 3, RR = 1.35, 95% CI: 1.03–1.77, p = 0.030), while risk of colorectal cancer was decreased (n = 3, RR = 0.78, 95% CI: 0.62–0.99, p = 0.037). Dose–response analysis indicated a positive linear association between ASB intake and the risk of leukemia (p-linear = 0.027). The risk increased by 15% per one serving (355 mL) daily ASB intake increment (RR = 1.15, 95% CI: 1.02–1.30). In conclusion, ASB consumption might be positively associated with the risk of leukemia and negatively associated with the risk of colorectal cancer.

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Section: Resultsmentioning

confidence: 99%

Section: Figurementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Artificially Sweetened Beverage Consumption and Cancer Risk: A Comprehensive Dose–Response Meta-Analysis of Prospective Studies

Yin

Wang

et al. 2022

Nutrients

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“…To represent the complexity of dietary intake, Zamora-Ros et al [23] performed a dietary pattern analysis. A total 450,064 adults from the European Prospective Investigation into Cancer and Nutrition cohort were involved in the study.…”

Section: Sugary Beverages In the Context Of The Eu Health Policy Debatementioning

confidence: 99%

The Lower the Better? Discussion on Non-Alcoholic Wine and Its Marketing

Schulz,

Farid,

Hanf

2023

Dietetics

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In the German beverage market, a shift in consumption has become apparent in recent decades: away from alcoholic beverages and towards non-alcoholic alternatives. This indicates a tradeoff between two important and nutritionally relevant substances: alcohol and sugar. This review, therefore, addresses the question of the significance of these developments to the German wine industry, where non-alcoholic wines and sparkling wines are becoming increasingly important. The production of these products is accompanied by a reduction in alcohol content with a simultaneous increase in sugar. Furthermore, these products could also become the focus of health policy efforts when it comes to accusations of possible “alibi marketing”. Here, parallels with the handling of tobacco products become clear, while the tradeoff between alcohol and sugar recedes into the background.

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“…In this context, we hypothesized that consumption of ASB can alter weight, and ultimately result in cancer and that weight may be a mediating factor between the two. So far, there have been scattered studies exploring ASB consumption with ORCs (22)(23)(24)(25)(26). Nevertheless, some disadvantages exist.…”

Section: Introductionmentioning

confidence: 99%

Artificially sweetened beverages consumption and risk of obesity-related cancers: a wide-angled Mendelian randomization study

Jin,

Wu,

Dong

et al. 2024

Front. Nutr.

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BackgroundThe impact of artificially sweetened beverages (ASBs) consumption on obesity-related cancers (ORCs) risk remains controversial. To address this challenging issue, this study employed wide-angle mendelian randomization (MR) analyses to explore the genetic causality between ASB consumption and the risk of ORCs, thereby effectively minimizing the impact of external confounders.MethodsWe conducted a suite of analyses encompassing univariable, multivariable, and two-step MR to evaluate causal associations between ASB consumption (samples = 85,852) and risk of ORCs (total samples = 2,974,770) using summary statistics from genome-wide association studies (GWAS). Total, direct, and intermediary effects were derived by performing inverse-variance weighted (IVW), MR-Egger, weighted mode, weighted median, and lasso method. Additionally, we performed an extensive range of sensitivity analyses to counteract the potential effects of confounders, heterogeneity, and pleiotropy, enhancing the robustness and reliability of the findings.ResultsGenetically predicted ASB consumption was positively associated with the risk of colorectal cancer (CRC, p = 0.011; OR: 6.879; 95% CI: 1.551, 30.512 by IVW) and breast cancer (p = 0.022; OR: 3.881; 95% CI: 2.023, 9.776 by IVW). Multivariable analysis yielded similar results. The results of the two-step MR unveiled that body mass index (BMI) assumes a pivotal role in mediating the association between ASB consumption and CRC risk (intermediary effect = 0.068, p = 0.024).ConclusionNo causal connection exists between ASB consumption and the majority of ORCs, in addition to CRC and breast cancer. Additionally, our findings suggest that BMI might be a potential mediator in the association between ASB consumption and CRC.

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Sweetened beverages are associated with a higher risk of differentiated thyroid cancer in the EPIC cohort: a dietary pattern approach

Cited by 6 publications

References 40 publications

Artificially Sweetened Beverage Consumption and Cancer Risk: A Comprehensive Dose–Response Meta-Analysis of Prospective Studies

Artificially Sweetened Beverage Consumption and Cancer Risk: A Comprehensive Dose–Response Meta-Analysis of Prospective Studies

The Lower the Better? Discussion on Non-Alcoholic Wine and Its Marketing

Artificially sweetened beverages consumption and risk of obesity-related cancers: a wide-angled Mendelian randomization study

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