Soil moisture‐dependent, quantitative information on sweetpotato [Ipomoea batatas L. (Lam)] plant processes is vital for crop management and modeling because of the projected shrinking and uneven distributions of rainfall and irrigation water supply due to climate change. This study was conducted to quantify the growth, physiology, biomass, and storage root yield responses of sweetpotato under four evapotranspiration‐based irrigation treatments (100, 60, 40, and 20% ET) in sunlit growth chambers. Irrigation treatments were imposed from 41 to 97 d after transplanting. Midday leaf water potentials (LWP) and soil moisture contents were measured throughout the experiment. Gas exchange and other physiological measurements were recorded during last 3 wk of the experiment. Plant growth and developmental parameters were measured at 97 d after transplanting. The midday LWP was strongly and linearly correlated with soil moisture content showing the interplay between these two processes. Net photosynthetic rate (Pn), stomatal conductance (Gs), and transpiration rate (Tr) declined while photosynthetic water‐use efficiency (Pn/Tr) increased with decreasing LWP. Both total chlorophyll content and cell membrane thermostability (CMT) declined linearly with decreasing LWP. Vine length, leaf area, and node number per plant decreased linearly, by 3.2 cm, 96.6 cm2, and 0.39 no. plant−1, respectively, per unit change in ET‐based irrigation. The optimum soil moisture for total plant and storage root dry weights were obtained under the irrigation treatments of 100 and 72% ET, respectively. Biomass partitioning to storage roots declined linearly and leaf and stem portioning increased with increased irrigation. Outcomes of this research will help producers schedule irrigation to maximize yield and researchers to develop sweetpotato crop models.