Swellable hollow periodic mesoporous organosilica capsules with ultrahigh loading capacity for hydrophobic drugs

Teng, Shiyong; Han, Yandong; Yang, Hu; Li, Jinshuo; Wang, Min; Guo, Zilong; Yang, Wensheng

doi:10.1016/j.jcis.2022.10.017

Cited by 14 publications

(8 citation statements)

References 34 publications

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“…The loading capacity (LC) of water in the capsules is calculated according to Equation () 33 :

LC = \frac{m_{0} - m_{1}}{m_{0}} \times 100 % .

…”

Section: Methodsmentioning

confidence: 99%

Rapid coating of millimeter‐scale hydrogel capsules with interfacial polymerization

Pan,

Huang,

Gong

et al. 2024

J of Applied Polymer Sci

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A rapid and mild coating strategy was applied on the millimeter scale calcium alginate capsules (Ca‐SA caps) by in situ interfacial polymerization of ethyl cyanoacrylate (ECA). The generated poly(ethyl cyanoacrylate) (PECA) coating was initiated by trace water in the surface of the Ca‐SA caps. The effects of ECA content, reaction time, and type of aromatic solvent on the morphology and control‐release property of the resulting PECA‐coated Ca‐SA caps (Ca‐SA caps@PECA) were investigated. The results demonstrated a white PECA layer successfully coated on the surface of Ca‐SA caps. Notably, the Ca‐SA caps@PECA remained consistently pleasing spherical shape as prepared in methylbenzene and ethylbenzene. When the ECA was 6 mL, the thickness of PECA layer of the Ca‐SA caps@PECA was 43.52 μm. Compared with the Ca‐SA caps, the weight retention ratio of water in the Ca‐SA caps@PECA increased by 254.61%, indicating the effective delay of water diffusion from core of the Ca‐SA caps@PECA. Moreover, the PECA coating improved the stability of the Ca‐SA caps@PECA, which achieved release‐controlling of dye at different pH. This method provides solution for surface modification of fragile hydrogel capsules to effectively control the releasing of liquid core, which is highly valuable in the field of food, cosmetic, and medical delivery.

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“…The loading capacity (LC) of water in the capsules is calculated according to Equation () 33 :

LC = \frac{m_{0} - m_{1}}{m_{0}} \times 100 % .

…”

Section: Methodsmentioning

confidence: 99%

Rapid coating of millimeter‐scale hydrogel capsules with interfacial polymerization

Pan,

Huang,

Gong

et al. 2024

J of Applied Polymer Sci

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“…Organic and inorganic hybrid hollow silica with ultra-thin shells can also achieve deformation through the swelling pH polypeptide polymer Not mentioned [44] pH PG@HGNs Not mentioned [46] Ultrasound liposomal nanodroplet Hydrophobic [23] Solvent activation pH BG-HA@CS Electrostatic interaction and hydrogen bond [49] pH Ce Physical adsorption [50] Not mentioned PMO Hydrophobic van der Waals forces [47] Chemical ond pH G-AuNPs-PEG Hydrazone bonds [34] pH Fe 3 O 4 @mSiO 2 @P2 Hydrophilic interaction hydrogen bond [52] pH MSN Amide bond physical adsorption [53] pH strategy of organic groups. Teng et al [47] fabricated hollow periodic mesoporous organosilicon (PMO) equipped with tunable shell thickness and low Young's modulus, thereby showing a swellability property in organic solvents. The hydrophobic drug resided in the hollow cavity after solution evaporation.…”

Section: Solvent Activation-controlled Drug Releasementioning

confidence: 99%

“…Teng et al. [ 47 ] fabricated hollow periodic mesoporous organosilicon (PMO) equipped with tunable shell thickness and low Young's modulus, thereby showing a swellability property in organic solvents. The hydrophobic drug resided in the hollow cavity after solution evaporation.…”

Section: Interactions and Responsive Release Mechanismmentioning

confidence: 99%

Response and Regulation of the Microenvironment Based on Hollow Structured Drug Delivery Systems

Zhao

Wei

Xiong

et al. 2023

Adv Funct Materials

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Hollow structured materials with easily modifiable surfaces and enclosed interior spaces have emerged as the most promising candidates in drug delivery systems (DDS). With various functional components and inspiring cavities for creative reinvention, the response and regulation of the external and internal microenvironment of hollow structures enable their ideal drug delivery capabilities by improving drug aggregation in targeted sites and maintaining plasma concentrations at the optimal therapeutic ranges. This review begins with an in-depth explanation of the interactions and release mechanisms of hollow structure-based DDS, including diffusion, assembly, solvent activation, and chemical control, all of which are of great significance for the design of smart drug carriers. Next, recent advances in external microenvironmentresponsive drug delivery systems are introduced, based on various chemical signals and external field assists. Focusing on the unique view of intra-carrier variability, the strategies for regulating the internal environment are then highlighted, including pH regulation, temperature regulation, and mechanical force regulation. Finally, this review discusses possible challenges and prospects for hollow structure-based, particularly hollow multishelled structures intelligence-responsive drug delivery platforms, providing valuable strategies for the development of the next generation of responsive DDS.

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“…Mesoporous materials have garnered significant interest for various applications, such as catalyst support, , adsorbents, , optical materials, − and drug-delivery carriers , because of their unique properties, such as high surface areas, large pore volumes, high biocompatibility, and high biodegradability. − Hollow mesoporous organosilica (HMOS) nanoparticles are a class of mesoporous materials with organic groups between inorganic silica frameworks in the mesoporous shell and large internal cavities. , When HMOS is used as a drug-delivery carrier, large amounts of drug molecules can be incorporated into its cavity. − Therefore, considerable research has focused on various applications of HMOS.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Monodispersed Hollow Mesoporous Organosilica and Silica Nanoparticles with Controllable Shell Thickness Using Soft and Hard Templates

2023

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Hollow mesoporous nanoparticles with controllable size (less than 100 nm) are desired as drug-delivery carriers. Herein, we report the synthesis of monodispersed hollow mesoporous organosilica (HMOS) and hollow mesoporous silica (HMS) nanoparticles using soft and hard templating methods. HMOS shells, with 1,2-bis(triethoxysilyl)ethane (BTEE) as the precursor and hexadecyltrimethylammonium bromide and sodium dodecyl sulfate (SDS) as the soft templates, were formed on monodispersed silica nanoparticles (SNPs), which were used as the hard templates. HMOS and HMS nanoparticles were obtained by removing the SNPs after three rounds of ammonia dialysis. The hollow size of HMOS can be tuned by changing the size of the SNPs. By using SNPs with a size of 36.5 nm, hollow spaces of approximately 20 nm connected the surface through narrow pores (<5 nm). Mesopores of approximately 12 nm were formed by the surfactant micelles. Additionally, the interparticle space in HMOS and HMS was approximately 12 nm. The shell thicknesses of HMOS and HMS could be tuned in the range of 5−9 nm by changing the BTEE amount. Moreover, the amount of surfactant used varied the porous structure. The HMOS with a thickness of 5 nm exhibited a Brunauer−Emmett−Teller (BET) surface area of 268 m 2 /g and a total pore volume of 1.14 cm 3 /g. Meanwhile, HMS demonstrated a BET surface area of 553 m 2 /g and a total pore volume of 1.82 cm 3 /g while maintaining a hollow structure. HMOS displayed a high loading capacity for ibuprofen (3009 mg/g), and its drug release system showed a sustained-release property. Therefore, the HMOS preparation using hard and soft templates proposed herein can control the hollow size and shell thickness for drug-delivery applications.

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Swellable hollow periodic mesoporous organosilica capsules with ultrahigh loading capacity for hydrophobic drugs

Cited by 14 publications

References 34 publications

Rapid coating of millimeter‐scale hydrogel capsules with interfacial polymerization

Rapid coating of millimeter‐scale hydrogel capsules with interfacial polymerization

Response and Regulation of the Microenvironment Based on Hollow Structured Drug Delivery Systems

Synthesis of Monodispersed Hollow Mesoporous Organosilica and Silica Nanoparticles with Controllable Shell Thickness Using Soft and Hard Templates

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