Swelling agents and devices in oral drug delivery

Omidian, Hossein; Park, K.

doi:10.1016/s1773-2247(08)50016-5

Cited by 145 publications

(84 citation statements)

References 67 publications

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“…Furthermore, their drug release patterns were similar with percent drug released after 8 h (Q 8 h ) ranging from 90.63 to 100. Thus, no considerable differences were observed among the three polymers as they seemed to behave similarly in modulating the drug release rate via formation of a gel layer around the tablets upon contact with dissolution medium followed by erosion of the swellable matrix into smaller particles exposing more surfaces for dissolution and drug release (66).…”

Section: In Vitro Drug Releasementioning

confidence: 99%

Gastroretentive Matrix Tablets of Boswellia Oleogum Resin: Preparation, Optimization, In Vitro Evaluation, and Cytoprotective Effect on Indomethacin-Induced Gastric Ulcer in Rabbits

et al. 2015

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Abstract. Currently available anti-ulcer drugs suffer from serious side effects which limited their uses and prompted the need to search for a safe and efficient new anti-ulcer agent. Boswellia gum resin (BR) emerged as a safe, efficient, natural, and economic potential cytoprotective agent. Thus, it is of medical importance to develop gastroretentive (GR) formulations of BR to enhance its bioavailability and antiulcer efficacy. Early attempts involved the use of organic solvents and non-applicability to large-scale production. In this study, different tablet formulations were prepared by simple direct compression combining floating and bioadhesion mechanisms employing hydroxypropyl methylcellulose (HPMC), sodium carboxymethyl cellulose (SCMC), pectin (PC), and/or carbopol (CP) as bioadhesive polymers and sodium bicarbonate (SB) as a gas former. The prepared tablets were subjected for assessment of swelling, floating, bioadhesion, and drug release in 0.1 N HCl. The optimized GR formulation was examined for its protective effect on the gastric ulcer induced by indomethacin in albino rabbits compared with lactose tablets. The obtained results disclosed that swelling, floating, bioadhesion, and drug release of the GR tablets of BR depend mainly on the nature of the matrix and the ratio of polymer combinations. Moreover, a combination of SCMC-CP in a ratio of 2:1 (SCP21) exhibited desirable floating, bioadhesion, swelling, and extended drug release. Also, a 6-h pretreatment with SCP21 tablets decreased the severity of inflammation and number of bleeding spots among ulcer-induced rabbits in comparison to those treated with lactose tablets.

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Section: In Vitro Drug Releasementioning

confidence: 99%

Gastroretentive Matrix Tablets of Boswellia Oleogum Resin: Preparation, Optimization, In Vitro Evaluation, and Cytoprotective Effect on Indomethacin-Induced Gastric Ulcer in Rabbits

et al. 2015

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“…The one way ANOVA and LSD analysis of the swelling ratio demonstrated that there were significant differences between all cinnamaldehyde groups (1, 2, 3%) and control group (p<0.05) but no differences among cinnamaldehyde groups. Swelling capability is the ability of the membrane expands as evidenced by weight gain when placed in liquid medium [21]. The swelling ability of the membrane is influenced by several factors, among others, the functional ionization groups along the polymer chains, crosslinking between molecules, hydrophilicity material, temperature, ionic strength, pH, and were influenced by the electrostatic force and osmotic water substances [21,22].…”

Section: Maximum Swelling Ratiomentioning

confidence: 99%

“…Swelling capability is the ability of the membrane expands as evidenced by weight gain when placed in liquid medium [21]. The swelling ability of the membrane is influenced by several factors, among others, the functional ionization groups along the polymer chains, crosslinking between molecules, hydrophilicity material, temperature, ionic strength, pH, and were influenced by the electrostatic force and osmotic water substances [21,22]. Chitosan has a good swelling capability in water, and when it is mixed with gelatin, they form the electrostatic interaction between ion amonium (-NH3 + ) from chitosan with carboxylate ion (-COO-) from gelatin [23].…”

Section: Maximum Swelling Ratiomentioning

confidence: 99%

Chitosan-gelatine membrane construct with different cinnamaldehyde concentration as drug delivery system in oral cavity

Ridwan¹,

Purwanti²,

Yulianto³

et al. 2016

AIP Conference Proceedings

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Abstract. The aim of the present study was to develop the chitosan-gelatin membrane for cinnamaldehyde control release since it has a crosslinking effect. Porous membranes with differences cinnamaldehyde concentration as an antiinflammatory agent in the size of ±1.5x1.5 cm, 1 mm thickness and weight around 0.27 g were prepared for measure the swelling ratio and weight loss. Scanning electron microscopy was carried out to describe the surface structure, and the chemical bonding was investigated by Fourier Transformed Infrared (F-TIR). The one way ANOVA and LSD analysis of the swelling ratio and weight loss demonstrated that there were significant differences between all cinnamaldehyde groups and a control group (p<0.05).

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“…Hydrophilic polymers that can swell are the main matrix excipients for most modifiedrelease tablet preparations (Omidian et al [1]; McCall et al [2]). Among all of the semi-synthetic polymers, cellulose ethers have been the most investigated (Baumgartner et al [3]; Conti et al [4]).…”

Section: Introductionmentioning

confidence: 99%

The reflection of the texture of swollen polymer matrix on the release of incorporated substance

Pavli

Kristl²,

Dolenc³

et al. 2009

E-Polymers

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Abstract:Our aim was to investigate the texture of hydrated biopolymer matrices that are now being considered in the design of pharmaceutical controlled-release dosage forms, in order to determine their influence on the release of an active compound. Prolonged release of pentoxifylline, a highly soluble drug, is needed for once-daily administration to achieve its therapeutic effect. For this purpose, pentoxifylline was incorporated in a polymer matrix made of a combination of xanthan and locust bean gum (XLBG), both of which are of biotechnological origin. Different methods were used to investigate the interplay of the XLBG gel structure characteristics in the absence and presence of 200 mM CaCl 2 on pentoxifylline release: drug-release studies, determination of swelling, erosion, and viscoelasticity of the gel, as well as its texture analysis and microscopic imaging. From the results obtained, the following conclusions can be drawn: the pentoxifylline release from XLBG matrices in water was prolonged for 24 h whereas from the control lactose formulation was completed within 30 min. The presence of Ca 2+ ions in water resulted in faster pentoxifylline release, in spite of less swelling and erosion. However, the rheology, texture analysis and scanning electron microscopy revealed that in the presence of the Ca 2+ ions the gel layer of the XLBG was more cohesive and thinner, as the attraction for water molecules was lower due to the condensation of counter-ions on the xanthan carboxylic-moieties, and consequently greater interpolymer interactions. Therefore, relatively larger amounts of free water molecules were available within the XLBG hydrogel in the presence of Ca 2+ , allowing faster drug dissolution and diffusion. Here, the presence of Ca 2+ ions had a completely opposite effect on XLBG gel structure and drug release in comparison with other more investigated matrix polymers like alginate or non-ionic cellulose ethers. A firm matrix structure that is accompanied by low swelling and erosion cannot guarantee a more prolonged drug release.

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Swelling agents and devices in oral drug delivery

Cited by 145 publications

References 67 publications

Gastroretentive Matrix Tablets of Boswellia Oleogum Resin: Preparation, Optimization, In Vitro Evaluation, and Cytoprotective Effect on Indomethacin-Induced Gastric Ulcer in Rabbits

Gastroretentive Matrix Tablets of Boswellia Oleogum Resin: Preparation, Optimization, In Vitro Evaluation, and Cytoprotective Effect on Indomethacin-Induced Gastric Ulcer in Rabbits

Chitosan-gelatine membrane construct with different cinnamaldehyde concentration as drug delivery system in oral cavity

The reflection of the texture of swollen polymer matrix on the release of incorporated substance

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