Swelling and drug release profile of poly(2‐ethyl‐2‐oxazoline)‐based hydrogels prepared by gamma radiation‐induced copolymerization

Ali, Amr El‐Hag; Alarifi, Abdullah

doi:10.1002/app.33480

Cited by 18 publications

(6 citation statements)

References 19 publications

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“…The authors use Ibuprofen as a model drug and give a proof on concept on the use of POx based hydrogels as controlled release modality for drug delivery to the gut. [193] Also Wiesbrock and co-workers reported on POx hydrogels with intended use stimuli-triggered drug delivery. In this case a model compound, eosin Y was released over time as the hydrogel decomposes.…”

Section: Other Drug Delivery Modalitiesmentioning

confidence: 99%

Poly(2‐oxazoline)s as Polymer Therapeutics

Luxenhofer

Han

Schulz

et al. 2012

Macromol. Rapid Commun.

427

325

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Poly(2-oxazoline)s (POx) are currently discussed as an upcoming platform for biomaterials design and especially for polymer therapeutics. POx meets several requirements needed for the development of next-generation polymer therapeutics such as biocompatibility, high modulation of solubility, variation of size, architecture as well as chemical functionality. Although in the early 1990s first and promising POx-based systems were presented but the field lay dormant for almost two decades. Only very recently, POx based polymer therapeutics came back into the focus of very intensive research. In this review, we give an overview on the chemistry and physicochemical properties of POx and summarize the research of POx-protein conjugates, POx-drug conjugates, POx-based polyplexes and POx micelles for drug delivery.

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Section: Other Drug Delivery Modalitiesmentioning

confidence: 99%

Poly(2‐oxazoline)s as Polymer Therapeutics

Luxenhofer

Han

Schulz

et al. 2012

Macromol. Rapid Commun.

427

325

View full text Add to dashboard Cite

show abstract

“…Of the limited research examining cross-linked POx, the pioneering studies were reported by the group of Seagusa who cross-linked partially hydrolyzed PMeOx using a variety of reversible and nonreversible methods or cross-linked through the use of bis-2-oxazoline comonomers. − Some of these studies were performed in aqueous conditions, but no biological applications were considered. More recently, cross-linking of PEtOx via γ-irradiation and microwave-assisted copolymerization with bis-2-oxazoline has been reported although neither of these approaches are suitable for encapsulation of cells or for use with fragile proteins. Other cross-linking approaches using POx as a copolymer or blend have been recently reviewed by Kelly and Wiesbrock …”

Section: Introductionmentioning

confidence: 99%

Poly(2-oxazoline) Hydrogels for Controlled Fibroblast Attachment

et al. 2013

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Currently there is a lack of choice when selecting synthetic materials with the cell-instructive properties demanded by modern biomaterials. The purpose of this study was to investigate the attachment of cells onto hydrogels prepared from poly(2-oxazoline)s selectively functionalized with cell adhesion motifs. A water-soluble macromer based on the microwave-assisted cationic ring-opening polymerization of 2-methyl-2-oxazoline and 2-(dec-9-enyl)-2-oxazoline was functionalized with the peptide CRGDSG or controls using thiol-ene photochemistry followed by facile cross-linking in the presence of a dithiol cross-linker. The growth of human fibroblasts on the hydrogel surfaces was dictated by the structure and amount of incorporated peptide. Controls without any peptide showed resistance to cellular attachment. The benignity of the cross-linking conditions was demonstrated by the incorporation of fibroblasts within the hydrogels to produce three-dimensional cell-polymer constructs.

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“…El‐Hag Ali and AlArifi prepared poly(2‐ethyl‐2‐oxazoline) (PEtOx)‐based hydrogels using gamma irradiation and characterized them with regard to their swelling profile and capacity, pH‐sensitivity and possible applicability as a colon‐specific drug delivery system, using ibuprofen as a model drug.…”

Section: Sterilization Of Hydrogel‐based Medical Devicesmentioning

confidence: 99%

Sterilization of hydrogels for biomedical applications: A review

et al. 2017

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Despite the beneficial properties and outstanding potential of hydrogels for biomedical applications, several unmet challenges must be overcome, especially regarding to their known sensitivity to conventional sterilization methods. It is crucial for any biomaterial to withstand an efficient sterilization to obtain approval from regulatory organizations and to safely proceed to clinical trials. Sterility assurance minimizes the incidence of medical device-related infections, which still constitute a major concern in health care. In this review, we provide a detailed and comprehensive description of the published work from the past decade regarding the effects of sterilization on different types of hydrogels for biomedical applications. Advances in hydrogel production methods with simultaneous sterilization are also reported. Terminal sterilization methods can induce negative or positive effects on several material properties (e.g., aspect, size, color, chemical structure, mechanical integrity, and biocompatibility). Due to the complexity of factors involved (e.g., material properties, drug stability, sterilization conditions, and parameters), it is important to note the virtual impossibility of predicting the outcome of sterilization methods to determine a set of universal rules. Each system requires case-by-case testing to select the most suitable, effective method that allows for the main properties to remain unaltered. The impact of sterilization methods on the intrinsic properties of these systems is understudied, and further research is needed. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 2472-2492, 2018.

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Swelling and drug release profile of poly(2‐ethyl‐2‐oxazoline)‐based hydrogels prepared by gamma radiation‐induced copolymerization

Cited by 18 publications

References 19 publications

Poly(2‐oxazoline)s as Polymer Therapeutics

Poly(2‐oxazoline)s as Polymer Therapeutics

Poly(2-oxazoline) Hydrogels for Controlled Fibroblast Attachment

Sterilization of hydrogels for biomedical applications: A review

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