Swept source optical coherence tomography for in vivo imaging and vibrometry in the apex of the mouse cochlea

Lee, Hee Yoon; Raphael, Patrick D.; Ellerbee, Audrey K.; Applegate, Brian E.; Oghalai, John S.

doi:10.1063/1.4939344

Cited by 3 publications

(1 citation statement)

References 10 publications

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“…Moreover, when OHC force is activated, it does not only act on the BM, but also RL magnitude and phase is expected to change. Recently, this RL motion was measured simultaneously with the BM [2,3]. A good correspondence between the model results of the BM and the RL, to corresponding measurements would further strengthen the hypothesis that the Y-shaped elements of the OoC play a critical building block for the cochlear amplifier.…”

Section: Introductionmentioning

confidence: 85%

Basilar membrane and reticular lamina motion in a multi-scale finite element model of the mouse cochlea

Soons¹,

Dirckx²,

Steele³

et al. 2015

AIP Conference Proceedings

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Section: Introductionmentioning

confidence: 85%

Basilar membrane and reticular lamina motion in a multi-scale finite element model of the mouse cochlea

Soons¹,

Dirckx²,

Steele³

et al. 2015

AIP Conference Proceedings

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The Spiral Staircase: Tonotopic Microstructure and Cochlear Tuning

Shera

2015

J. Neurosci.

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Although usually assumed to be smooth and continuous, mammalian cochlear frequency-position maps are predicted to manifest a staircase-like structure comprising plateaus of nearly constant characteristic frequency separated by abrupt discontinuities. The height and width of the stair steps are determined by parameters of cochlear frequency tuning and vary with location in the cochlea. The step height is approximately equal to the bandwidth of the auditory filter (critical band), and the step width matches that of the spatial excitation pattern produced by a low-level pure tone. Stepwise tonotopy is an emergent property arising from wave reflection and interference within the cochlea, the same mechanisms responsible for the microstructure of the hearing threshold. Possible relationships between the microstructure of the cochlear map and the tiered tonotopy observed in the inferior colliculus are explored.

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Multiple Wavelength Optical Coherence Tomography Assessments for Enhanced Ex Vivo Intra-Cochlear Microstructural Visualization

et al. 2018

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The precise identification of intra-cochlear microstructures is an essential otorhinolaryngological requirement to diagnose the progression of cochlea related diseases. Thus, we demonstrated an experimental procedure to investigate the most optimal wavelength range, which can enhance the visualization of ex vivo intra-cochlear microstructures using multiple wavelengths (i.e., 860 nm, 1060 nm, and 1300 nm) based optical coherence tomography (OCT) systems. The high-resolution tomograms, volumetric, and quantitative evaluations obtained from Basilar membrane, organ of Corti, and scala vestibule regions revealed complementary comparisons between the aforementioned three distinct wavelengths based OCT systems. Compared to 860 nm and 1300 nm wavelengths, 1060 nm wavelength OCT was discovered to be an appropriate wavelength range verifying the simultaneously obtainable high-resolution and reasonable depth range visualization of intra-cochlear microstructures. Therefore, the implementation of 1060 nm OCT can minimize the necessity of two distinct OCT systems. Moreover, the results suggest that the performed qualitative and quantitative analysis procedure can be used as a powerful tool to explore further anatomical structures of the cochlea for future studies in otorhinolaryngology.

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Swept source optical coherence tomography for in vivo imaging and vibrometry in the apex of the mouse cochlea

Cited by 3 publications

References 10 publications

Basilar membrane and reticular lamina motion in a multi-scale finite element model of the mouse cochlea

Basilar membrane and reticular lamina motion in a multi-scale finite element model of the mouse cochlea

The Spiral Staircase: Tonotopic Microstructure and Cochlear Tuning

Multiple Wavelength Optical Coherence Tomography Assessments for Enhanced Ex Vivo Intra-Cochlear Microstructural Visualization

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