Swertia bimaculata moderated liver damage in mice by regulating intestine microbiota

He, Xiuping; Peng, Hao; Wang, Yun; Wu, Chen; Yin, Wen; Shahid, Muhammad Akbar; Wu, Shengbo; Nawaz, Shah; Du, Wan; Xu, Yancong; Chen, Yu; Wu, Yi; Ye, Yuhan; Fan, Junting; Mehmood, Khalid; Li, Kun; Ju, Jianming

doi:10.1016/j.ecoenv.2023.115223

Cited by 5 publications

(2 citation statements)

References 57 publications

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“…Based on the above background and previous fluoride studies in the laboratory [28], we constructed fluoride-treated mouse models by freely drinking distilled water containing 100 mg/L sodium fluoride for 18 weeks. Of note, Bifidobacterium was regarded as an effective therapeutic approach for alleviating liver and intestinal damage [29]. Here, the administration of 1 × 10 9 CFU/mL Bifidobacterium is based on the research by Xin et al [30].…”

Section: Discussionmentioning

confidence: 99%

Bifidobacterium Relieved Fluoride-Induced Hepatic and Ileal Toxicity via Inflammatory Response and Bile Acid Transporters in Mice

Wu,

Cheng,

Wang

et al. 2024

Foods

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Fluoride is a pervasive environmental contaminant. Prolonged excessive fluoride intake can inflict severe damage on the liver and intestines. Previous 16S rDNA sequencing revealed a decrease in ileal Bifidobacterium abundance during fluoride-induced hepatointestinal injury. Hence, this work aimed to investigate the possible mitigating function of Bifidobacterium on hepatointestinal injury caused by fluoride. Thirty-six 6-week-old C57BL/6J mice (equally divided between males and females) were allotted randomly to three groups: Ctrl group (distilled water), NaF group, and NaF + Ba group (100 mg/L NaF distilled water). After 10 weeks, the mice were given 1 × 109 CFU/mL Bifidobacterium solution (0.2 mL/day) intragastrically in the NaF + Ba group for 8 weeks, and the mice in other groups were given the same amount of distilled water. Dental damage, bone fluoride content, blood routine, liver and intestinal microstructure and function, inflammatory factors, and regulatory cholic acid transporters were examined. Our results showed that fluoride increased glutamic-oxalacetic transaminase (GOT), glutamic-pyruvic transaminase (GPT) activities, and the levels of lipopolysaccharide (LPS), IL-1β, IL-6, TNF-α, and IL-10 levels in serum, liver, and ileum. However, Bifidobacterium intervention alleviated fluoride-induced changes in the above indicators. In addition, Bifidobacterium reduced the mRNA expression levels of bile acid transporters ASBT, IBABP, OST-α, and OST-β in the ileum. In summary, Bifidobacterium supplementation relieved fluoride-induced hepatic and ileal toxicity via an inflammatory response and bile acid transporters in the liver and ileum of mice.

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Section: Discussionmentioning

confidence: 99%

Bifidobacterium Relieved Fluoride-Induced Hepatic and Ileal Toxicity via Inflammatory Response and Bile Acid Transporters in Mice

Wu,

Cheng,

Wang

et al. 2024

Foods

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“…Muribaculaceae can degrade dietary and polysaccharides to produce short-chain fatty acids and exhibits anti-inflammatory and glycolipid homeostasis balancing properties ( 44 ). Bifidobacterium can improve high-fat diet-induced hepatic steatosis and intestinal inflammation, and has several beneficial functions, such as improving liver function, lowering blood lipids, regulating intestinal environment, and anti-aging ( 45 – 48 ). The Bifidobacterium level is significantly higher in healthy individuals, and it has a protective activity against T2DM and negatively correlates with T2DM ( 49 – 54 ).…”

Section: Discussionmentioning

confidence: 99%

Total Astragalus saponins can reverse type 2 diabetes mellitus-related intestinal dysbiosis and hepatic insulin resistance in vivo

Ma,

La,

Zhang

et al. 2023

Front. Endocrinol.

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ObjectiveIntestinal flora homeostasis in rats with type 2 diabetes mellitus (T2DM) was evaluated to explore the effects of total Astragalus saponins (TAS) on hepatic insulin resistance (IR).MethodsSix-week-old male Sprague–Dawley rats were fed high-fat and high-sugar diet for 4 weeks and intraperitoneally injected with streptozotocin to induce T2DM, and they were then randomly divided into control, model, metformin, and TAS groups. Stool, serum, colon, and liver samples were collected after 8 weeks of drug administration for relevant analyses.ResultsTAS reduced fasting blood glucose, 2-hour postprandial blood glucose, area under the curve of oral glucose tolerance test, glycated serum protein, homeostasis model assessment of insulin resistance, total cholesterol, triglyceride, and low-density lipoprotein cholesterol levels in T2DM rats but increased insulin, C-peptide, and high-density lipoprotein cholesterol levels. Moreover, TAS improved the morphology and structure of liver and colon tissues and improved the composition of the intestinal microbiome and bacterial community structure at different taxonomic levels. In addition, TAS increased the protein expression of hepatic IRS-1, PI3K, PDK1, and p-AKT and decreased the protein expression of p-GSK-3β. Meanwhile, TAS increased the mRNA expression of liver PDK1, PI3K, and GS and decreased the mRNA expression of GSK-3β.ConclusionTAS can ameliorate T2DM-related abnormal glucose and blood lipid metabolism, intestinal dysbiosis, and IR.

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The effect of Abrus cantoniensis Hance on liver damage in mice

Li,

Tu,

Dai

et al. 2023

Ecotoxicology and Environmental Safety

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Swertia bimaculata moderated liver damage in mice by regulating intestine microbiota

Cited by 5 publications

References 57 publications

Bifidobacterium Relieved Fluoride-Induced Hepatic and Ileal Toxicity via Inflammatory Response and Bile Acid Transporters in Mice

Bifidobacterium Relieved Fluoride-Induced Hepatic and Ileal Toxicity via Inflammatory Response and Bile Acid Transporters in Mice

Total Astragalus saponins can reverse type 2 diabetes mellitus-related intestinal dysbiosis and hepatic insulin resistance in vivo

The effect of Abrus cantoniensis Hance on liver damage in mice

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