SWI or T2*: Which MRI Sequence to Use in the Detection of Cerebral Microbleeds? The Karolinska Imaging Dementia Study

Shams, Sara; Martola, Juha; Cavallin, Lena; Granberg, Tobias; Shams, Mana; Aspelin, Peter; Wahlund, Lars‐Olof; Wiberg, Maria Kristoffersen

doi:10.3174/ajnr.a4248

Cited by 106 publications

(82 citation statements)

References 20 publications

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“…The present study used an SWI sequence obtained at 3T, while previous reports in controls used 1.5T machines and/or T2* sequences. It has been shown that SWI sequences detect more CMBs than 2D gradient-recalled echo sequences, [30][31][32] with an increase in detected lesions of 67% according to Nandigam et al 30 As in our study, the prevalence of CMBs was relatively similar in patients with MCI and controls (14% and 11%, respectively) in the cohort of Ayaz et al, 33 including 28 healthy controls and 75 subjects with MCI examined at 1.5T with a SWI sequence. Other studies found an association between CMBs and low cognitive performance 12 or cognitive decline.…”

Section: Prevalence Of Cmbssupporting

confidence: 59%

Clinicoradiologic Correlations of Cerebral Microbleeds in Advanced Age

Barnaure¹,

Montandon²,

Rodriguez³

et al. 2016

AJNR Am J Neuroradiol

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Section: Prevalence Of Cmbssupporting

confidence: 59%

Clinicoradiologic Correlations of Cerebral Microbleeds in Advanced Age

Barnaure¹,

Montandon²,

Rodriguez³

et al. 2016

AJNR Am J Neuroradiol

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“…14,22,23 Higher field strengths are associated with higher detection rates, whereas susceptibility weighted imaging promises superiority over T2*-weighted imaging. 22,23 The first description of cMBs in Asian patients with MMD revealed a detection rate of 44% of patients at 3 Tesla with T2* sequence versus 28% at 1.5 Tesla.…”

Section: Discussionmentioning

confidence: 99%

Incidence, Locations, and Longitudinal Course of Cerebral Microbleeds in European Moyamoya

Wenz

Maros

et al. 2017

Stroke

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Background and Purpose-Cerebral microbleeds (cMBs) have previously been linked with especially high incidence in Asian patients with moyamoya together with high tendency to bleed. This, presumably, is characteristic of patients with moyamoya. Herein, we, therefore, investigate retrospectively the frequency, location, and longitudinal course of cMBs in a large German cohort. Methods-We included all patients with moyamoya who underwent standard magnetic resonance imaging, including T2*-weighted images, in our department between 1998 and 2015. Two independent readers evaluated magnetic resonance imaging scans to determine the occurrence of cMBs according to the Brain Observer Microbleed Scale. Demographics, initial symptoms leading to hospitalization, and associated diseases were obtained by chart review. Results-Overall, there was a total of 242 T2* studies of 101 included moyamoya patients available with a strong female predominance (69.3%). Eight patients (7.9%) were ≤18 years of age. We detected 25 cMBs within 13 patients (12.9%).One patient <18 of age was presented with a cMB; 2 of 3 patients with an intracranial hemorrhage as initial event demonstrated cMB(s). In 72 of 101 cases, there were 1719 person months of follow-up, with 3 adult patients showing 3 de novo cMBs in the course. The majority of cMBs (64.0%) were located at the cortex/gray-white junction. Conclusions-Although the frequency of cMBs herein is much higher than the expected age-specific incidence, it is still much lower compared with previous reports on cMBs in moyamoya patients of Asian descent. These results might reflect another ethnic-specific difference in patients diagnosed with moyamoya.

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“…Supplementary Table 2 shows the distribution over diagnostic groups on the 3.0T scanner and SWI sequence which are most sensitive to CMBs. 16 …”

Section: Mri Protocolmentioning

confidence: 99%

Cerebral microbleeds topography and cerebrospinal fluid biomarkers in cognitive impairment

Shams

Granberg

Martola

et al. 2016

J Cereb Blood Flow Metab

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Cerebral microbleeds, a marker of small vessel disease, are thought to be of importance in cognitive impairment. We aimed to study topographical distribution of cerebral microbleeds, and their involvement in disease pathophysiology, reflected by cerebrospinal fluid biomarkers; 1039 patients undergoing memory investigation underwent lumbar puncture and a brain magnetic resonance imaging scan. Cerebrospinal fluid samples were analyzed for amyloid b(Ab)42, total tau(T-tau), tau phosphorylated at threonine 18(P-tau) and cerebrospinal fluid/serum albumin ratios. Magnetic resonance imaging sequences were evaluated for small vessel disease markers, including cerebral microbleeds, white matter hyperintensities and lacunes. Low Ab42 levels were associated with lobar cerebral microbleeds in the whole cohort and Alzheimer's disease (P < 0.001). High cerebrospinal fluid/serum albumin ratios were seen with increased number of cerebral microbleeds in the brainstem (P < 0.001). There were tendencies for increased Ab42 levels and decreased Tau levels with deep and infratentorial cerebral microbleeds (P < 0.05). Lobar cerebral microbleeds were associated with white matter hyperintensities and lacunes (P < 0.001). Probable cerebral amyloid angiopathy-related cerebral microbleeds were associated with low Ab42 levels and lacunes, whereas probable cerebral amyloid angiopathy-unrelated cerebral microbleeds were associated with white matter hyperintensities (P < 0.001). Our findings show that cerebral microbleed distribution is associated with different patterns of cerebrospinal fluid biomarkers, supporting different pathogenesis of deep/infratentorial and lobar cerebral microbleeds.

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SWI or T2*: Which MRI Sequence to Use in the Detection of Cerebral Microbleeds? The Karolinska Imaging Dementia Study

Cited by 106 publications

References 20 publications

Clinicoradiologic Correlations of Cerebral Microbleeds in Advanced Age

Clinicoradiologic Correlations of Cerebral Microbleeds in Advanced Age

Incidence, Locations, and Longitudinal Course of Cerebral Microbleeds in European Moyamoya

Cerebral microbleeds topography and cerebrospinal fluid biomarkers in cognitive impairment

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