SwiftTCR: Efficient Computational Docking protocol of TCRpMHC-I Complexes Using Restricted Rotation Matrices
Farzaneh Meimandi Parizi,
Yannick J. M. Aarts,
Sanna Eerden
et al.
Abstract:The T cell’s ability to discern self and non-self depends on its T cell receptor (TCR), which recognizes peptides presented by MHC molecules. Understanding this TCR-peptide-MHC (TCRpMHC) interaction is important for cancer immunotherapy design, tissue transplantation, pathogen identification, and autoimmune disease treatments. Understanding the intricacies of TCR recognition, encapsulated in TCRpMHC structures, remains challenging due to the immense diversity of TCRs (>10^8/individual), rendering experiment… Show more
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