Swimming exercise attenuates anxiety-like behavior by reducing brain oxidative stress in type 2 diabetic mice

Matinfar, Parinaz; Peeri, Maghsoud; Azarbayjani, Mohammad Ali

doi:10.1016/j.physbeh.2021.113449

Cited by 24 publications

(6 citation statements)

References 71 publications

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“…Our work demonstrated the modulation of a cortico-amygdala neural circuit by exercise training in improving stress resilience. Currently available explanations for physical exercise and mental health mainly explored the regulation of brain homeostasis such as neuroinflammation 10 , 24 , cerebrovascular function 25 , 26 or oxidative stress 9 , 27 . These changes in brain microenvironment further contribute to the acceleration of adult neurogenesis, leading to the improvement of mental 8 , 28 or cognitive functions 7 , 29 , 30 .…”

Section: Discussionmentioning

confidence: 99%

Treadmill exercise modulates the medial prefrontal-amygdala neural circuit to improve the resilience against chronic restraint stress

Luo

Dai

et al. 2023

Commun Biol

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Aerobic exercise effectively ameliorates mental disorders including anxiety and depression. Current findings mainly attribute its neural mechanism to the improvement of adult neurogenesis, while leaving the possible circuitry mechanism unclear. In the current study, we identify the overexcitation of the medial prefrontal cortex (mPFC) to basolateral amygdala (BLA) pathway under chronic restraint stress (CRS), and 14-day treadmill exercise selectively reverses such abnormalities. Using chemogenetic approaches, we find that the mPFC-BLA circuit is necessary for preventing anxiety-like behaviors in CRS mice. These results collectively suggest a neural circuitry mechanism by which exercise training improves the resilience against environmental stress.

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Section: Discussionmentioning

confidence: 99%

Treadmill exercise modulates the medial prefrontal-amygdala neural circuit to improve the resilience against chronic restraint stress

Luo

Dai

et al. 2023

Commun Biol

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“…The increasing concentration of S‐100β might participate in nerve damage and apoptosis by activating an oxidative stress reaction 25 . Previous studies showed that oxidative stress was correlated with anxiety‐like behaviour after acute stress 26–28 . In addition, as a marker of the integrity of the blood–brain barrier, S‐100β has proved to be associated with blood–brain barrier damage 10 .…”

Section: Discussionmentioning

confidence: 99%

“…25 Previous studies showed that oxidative stress was correlated with anxiety-like behaviour after acute stress. [26][27][28] In addition, as a marker of the integrity of the blood-brain barrier, S-100β has proved to be associated with blood-brain barrier damage. 10 Recent experimental data indicated that anxiety and depressive-like behaviours occurring as a result of stressful situations might be caused by blood-brain barrier dysfunction, which is characterized by inflammation and leakage.…”

Section: Discussionmentioning

confidence: 99%

The relationship between serum levels of S‐100β and anxiety symptoms in patients with acute stroke

Wang

Xiao

et al. 2022

Psychogeriatrics

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Background: Post-stroke anxiety (PSA) is a common neuropsychiatric affective disorder occurring after a stroke. Animal experiments have indicated that serum S-100β levels are closely related to anxiety disorder. No clinical study has been done to explore the relationship between serum S-100β levels and anxiety symptoms in patients with acute stroke. The aim of our study was to investigate the association between serum S-100β levels and PSA. Methods: One hundred twenty-six acute stroke patients were recruited and followed up for 1 month. Blood samples were collected within 24 h after admission. The levels of serum S-100β were measured by enzyme-linked immunosorbent assays. Patients with significant clinical symptoms of anxiety and a Hamilton Anxiety Rating Scale score >7 at 1 month after stroke were diagnosed as PSA. Results: Serum S-100β levels in the non-PSA group were lower than the PSA group (838.97 (678.20-993.59) ng/L vs. 961.87 (796.09-1479.59) ng/L, Z = À2.661, P = 0.008). In multivariate analyses, we found that decreased risk of PSA was associated with low tertile serum S-100β levels (≤753.8 ng/L, OR 0.062, 95% CI 0.008-0.475, P = 0.007). Conclusions: Low serum S-100β levels at admission may be associated with the decreased risk of PSA.

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“…Tired animals that appeared distressed were allowed to rest for 5 min before finishing the swim session (Shen et al, 2013). Setting the type and size of the water tank, water temperature, and stages of adaptation before the core swim were any efforts by researchers to prevent stress in experimental animals (Matinfar et al, 2021). This training protocol and the water temperature were designed to mimic clinically relevant physical therapy programs (Shen et al, 2013).…”

Section: Swimming Exercisementioning

confidence: 99%

Effects of swimming exercise and RLN2 induction on relaxin levels, MMP-13, TGFβ expression in the pubic cartilage of pregnant rats

Oktaviani¹,

Wihastuti²,

Rahardjo³

et al. 2022

J Pharm Pharmacogn Res

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Context: Swimming exercises can be used as an intervention to maintain the stability of the synthesis of the pubic symphysis cartilage. Aims: To evaluate the effects of swimming exercise on relaxin levels, MMP-13, TGFβ expression in pubic cartilage at pregnant rats with induction of RLN2 gene. Methods: Thirty-six female Wistar rats (six in each group) were impregnated with 24 male rats (1:1). Three groups had swimming exercises for 60 min per day, and the other groups were treated as the control group. Two groups were given subcutaneous RLN2 gene. Relaxin plasma was collected from the sinus retro-orbital and performed twice on the eighth day and the 20th of pregnancy. The pubic symphysis of the rats was collected on the 20th day of pregnancy, and the decalcification process was carried out before making histological preparations. Results: There was an increase in the amount of relaxin in the relaxin-induced group after 24 h induction (p=0.000). Relaxin levels of pregnant rats on the 20th day correlated with the expression of MMP-13, p=0.029; R2=0.447. In the treatment group, relaxin levels and MMP-13 expression were lower than the non-treatment group, p=0.005 and p=0.000, respectively. In contrast, there was a higher expression of TGFβ in the treatment group, p=0.000. Conclusions: Relaxin plasma levels have a significant correlation with the expression of MMP-13, and swimming exercise increases the expression of TGFβ and decreases relaxin levels and MMP-13 expression in the pubic cartilage.

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Swimming exercise attenuates anxiety-like behavior by reducing brain oxidative stress in type 2 diabetic mice

Cited by 24 publications

References 71 publications

Treadmill exercise modulates the medial prefrontal-amygdala neural circuit to improve the resilience against chronic restraint stress

Treadmill exercise modulates the medial prefrontal-amygdala neural circuit to improve the resilience against chronic restraint stress

The relationship between serum levels of S‐100β and anxiety symptoms in patients with acute stroke

Effects of swimming exercise and RLN2 induction on relaxin levels, MMP-13, TGFβ expression in the pubic cartilage of pregnant rats

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