Swimming Program on Mildly Diabetic Rats in Pregnancy

Macedo, Nathália Cristine Dias; Iessi, Isabela Lovizutto; Gallego, Franciane Quintanilha; Netto, A.O.; Sinzato, Yuri Karen; Volpato, Gustavo Tadeu; Zambrano, Elena; Damasceno, Débora Cristina

doi:10.1007/s43032-021-00462-0

Cited by 9 publications

(4 citation statements)

References 50 publications

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“…Results showed that CBR mRNA expression was decreased in trained ZDF rats, and the decreased ketone and reactive oxygen species production might be the reason for the benefits of exercise in islet toxicity and cell death. One article estimated the effect of moderate swimming on glycemic control and non-toxic oxidative stress in pregnant mildly diabetic rats and concluded that glucose tolerance and islet morphology were positively correlated with aerobic training [ 42 ].…”

Section: Resultsmentioning

confidence: 99%

Impacts of an Exercise Intervention on the Health of Pancreatic Beta-Cells: A Review

Zhang

Wei

Wang

2022

IJERPH

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There is an increasing consensus that exercise is a medicine and that regular exercise can effectively improve and prevent metabolic diseases such as diabetes. Islet cells are the endocrine of the pancreas and vital to the development of diabetes. Decades of developmental research in exercise intervention and the health of islet cells confirmed that exercise exerts beneficial effects on the function, proliferation, and survival rate of islet cells. However, the precise exercise reference scheme is still elusive. To accomplish this goal, we searched and analyzed relevant articles, and concluded the precise exercise prescription treatments for various species such as humans, rats, and mice. Each exercise protocol is shown in the tables below. These exercise protocols form a rich pipeline of therapeutic development for exercise on the health of islet cells.

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Section: Resultsmentioning

confidence: 99%

Impacts of an Exercise Intervention on the Health of Pancreatic Beta-Cells: A Review

Zhang

Wei

Wang

2022

IJERPH

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“…After weighing the fetuses, the analysis of external anomalies was performed. Newborns were examined externally, with detailed analysis of eyes, mouth, ear implantation, cranial conformation, fore and hind limbs, anal perforation, and tail (Macedo et al, 2021). After external examination, half of the newborns from each litter were placed in Bodian's solution to fix the visceral structures and decalcify the bones.…”

Section: Fetal Analysismentioning

confidence: 99%

Maternal and Fetal-Placental Effects of Etanercept Treatment During Rats’ Pregnancy

et al. 2022

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Etanercept is a tumor necrosis factor alpha (TNF-α) inhibitor chronically used to treat autoimmune diseases. However, the use of etanercept during pregnancy still needs to be further investigated. The aim of this study is to evaluate the etanercept treatment during pregnancy, analyzing maternal reproductive performance, fetal outcomes, and placental repercussions. Wistar rats (200–250 g) were mated and randomly distributed into two experimental groups: control and etanercept (n = 10 animals/group). Treatments with etanercept (0.8 mg/kg, s.c.), or saline (control group) were carried out on days 0, 6, 12, and 18 of gestation. On the morning of the 21st day of pregnancy, rats were euthanized in a CO2 chamber and submitted to laparotomy to remove the fetuses, placentas, ovaries, and maternal organs. There were no differences between groups in the following parameters: water and food consumption; placental efficiency; reproductive parameters, including number of corpora lutea and implants, reabsorption, and pre- and post-implantation losses. However, etanercept treatment increased liver weight, reduced fetal and placental weight, decreased the placental junction zone, reduced the percentage of normal fetuses, and increased visceral or skeletal fetal abnormalities. Therefore, etanercept resulted in damages more related to fetus and placenta. However, more studies with different doses are required to better predict possible injuries elicited using etanercept during pregnancy.

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“…On day 75 of life, the Oral Glucose Tolerance Test (OGTT) was performed to assess the glycemic values, which characterized the inclusion criteria of the rats. 28 For this, after six hours of fasting, a drop of blood was obtained from the distal end of the animal's tail, which was introduced into a conventional glucometer for glycemic determination (time 0). Following, the rats received glucose solution (0.2 g/ mL) via intragastric (gavage) at a dose of 2.0 g/kg of body weight.…”

Section: An Experimental Sequence Of Parental Generation (Mother Rats)mentioning

confidence: 99%

Exposure to maternal hyperglycemia and high-fat diet consumption after weaning in rats: repercussions on periovarian adipose tissue

Saullo

Sinzato

Paula

et al. 2021

J Dev Orig Health Dis

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Clinical and epidemiological studies show that maternal hyperglycemia can change the programming of offspring leading to transgenerational effects. These changes may be related to environmental factors, such as high-fat diet (HFD) consumption, and contribute to the comorbidity onset at the adulthood of the offspring. The objective of this study was to evaluate the hyperglycemic intrauterine environment, associated or not with an HFD administered from weaning to adult life on the periovarian adipose tissue of rat offspring Maternal diabetes was chemically induced by Streptozotocin. Female offsprings were randomly distributed into four experimental groups (n = 5 animals/group): Female offspring from control or diabetic mothers and fed an HFD or standard diet. HFD was prepared with lard enrichment and given from weaning to adulthood. On day 120 of life, the rats were anesthetized and sacrificed to obtain adipose tissue samples. Then, the hyperglycemic intrauterine environment and HFD fed after weaning caused a higher body weight, total fat, and periovarian fat in adult offspring, which could compromise the future reproductive function of these females. These rats showed higher adiposity index and adipocyte area, contributing to hypertrophied adipose tissue. Therefore, maternal diabetes itself causes intergenerational changes and, in association with the HFD consumption after weaning, exacerbated the changes in the adipose tissue of adult female offspring.

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Swimming Program on Mildly Diabetic Rats in Pregnancy

Cited by 9 publications

References 50 publications

Impacts of an Exercise Intervention on the Health of Pancreatic Beta-Cells: A Review

Impacts of an Exercise Intervention on the Health of Pancreatic Beta-Cells: A Review

Maternal and Fetal-Placental Effects of Etanercept Treatment During Rats’ Pregnancy

Exposure to maternal hyperglycemia and high-fat diet consumption after weaning in rats: repercussions on periovarian adipose tissue

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