Swimming Training Mitigates Neurological Impairment of Intracerebral Haemorrhage in Mice via the Serine-Threonine Kinase/Glycogen Synthase Kinase 3β Signalling Pathway

Li, Yongxu; Lu, Taotao; Wei, Wei; Lin, Zhenyang; Ding, Linlin; Li, Zhaohui; Xue, Xiehua

doi:10.1016/j.neuroscience.2022.07.027

Cited by 1 publication

(2 citation statements)

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“…Although some patients may achieve > 200 repetitions/day, the average number of task repetitions completed in upper limb clinical rehabilitation trials is 23-32 repetitions/session, and decreases as impairment increases [86]. Despite the clinical importance, only ~ 1/3 of articles systematically compared factors such as treatment onset [41,43,57], type [42,44,54,[59][60][61], or dose [41,53,62,66]. Mixed results were often reported, underscoring the need for additional confirmatorytype studies in ICH that systematically manipulate and directly compare the impact of treatment parameters.…”

Section: Discussionmentioning

confidence: 99%

“…Histological assessment of stroke severity (lesion or hematoma volume) was included in the methods of 34/48 interventions; however, we could not identify the full range of stroke severity studied as results were often unreported or unclear (e.g., assessed in one brain slice). Rehabilitation interventions were grouped into six categories: AE [38][39][40][41][42][43][44][45][46][47], ER [48][49][50][51][52][53], CIMT + FLU [54][55][56][57][58], REACH [59][60][61][62], AT [15,63,64], and OTHER (complex exercise [54], EE [65], walking [59,61], swimming [66]).…”

Section: Descriptive Characteristicsmentioning

confidence: 99%

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Motor Rehabilitation Provides Modest Functional Benefits After Intracerebral Hemorrhage: a Systematic Review and Meta-Analysis of Translational Rehabilitation Studies

Fedor,

Sander,

MacLaren

et al. 2023

Transl. Stroke Res.

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Few certainties exist regarding the optimal type, timing, or dosage of rehabilitation after stroke. Despite differing injury mechanisms and recovery patterns following ischemic and hemorrhagic stroke, most translational stroke research is conducted after ischemia. As we enter the era of personalized medicine, exploring subtype-specific treatment efficacy is essential to optimizing recovery. Our objective was to characterize common rehabilitation interventions used after in vivo preclinical intracerebral hemorrhage (ICH) and assess the impact of post-ICH rehabilitation (vs. no-rehabilitation) on recovery of motor function. Following PRISMA guidelines, a systematic review (Academic Search Complete, CINAHL, EMBASE, Medline, PubMed Central) identified eligible articles published up to December 2022. Risk of bias (SYRCLE) and study quality (CAMARADES) were evaluated, and random-effects meta-analysis was used to assess treatment efficacy in recovery of forelimb and locomotor functions. Thirty articles met inclusion criteria, and 48 rehabilitation intervention groups were identified. Most used collagenase to model striatal ICH in young, male rodents. Aerobic exercise, enriched rehabilitation, and constraint-induced movement therapy represented ~ 70% of interventions. Study quality was low (median 4/10, range 2–8), and risk of bias was unclear. Rehabilitation provided modest benefits in skilled reaching, spontaneous impaired forelimb use, and locomotor function; however, effects varied substantially by endpoint, treatment type, and study quality. Rehabilitation statistically improves motor function after preclinical ICH, but whether these effects are functionally meaningful is unclear. Incomplete reporting and variable research quality hinder our capacity to analyze and interpret how treatment factors influence rehabilitation efficacy and recovery after ICH.

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