Swimming training prevents alterations in ecto-NTPDase and adenosine deaminase activities in lymphocytes from Nω-nitro-L-arginine methyl ester hydrochloride induced hypertension rats

Cardoso, Andréia Machado; Abdalla, Fátima Husein; Bagatini, Margarete Dulce; Martins, Cibele Chalita; Zanini, Daniela; Schmatz, Roberta; Jaques, Jeandre Augusto dos Santos; Leal, Daniela Bitencourt Rosa; Morsch, Vera Maria; Schetinger, Maria Rosa Chitolina

doi:10.1097/hjh.0000000000000468

Cited by 23 publications

(21 citation statements)

References 41 publications

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“…In contrast, regular exercise training has been associated with a significant protection against immuno-inflammatory process. Its protective effect is due to the ability to enhance mitochondrial performance and to prevent the ATP release and then the inflammasome activation [7,25]. Corroborating with these findings, we observed that the regular exercise training was able to restore the metabolic and inflammatory homeostasis as well as to reverse the alterations observed in E-NTPDase and ADA activities of lymphocytes in MetS patients.…”

Section: Discussion ▼supporting

confidence: 78%

“…Then, by controlling the extracellular adenine nucleotide and nucleoside levels, ectonuclotidase enzymes, such as E-NTPDase and ADA, are able to regulate the immune homeostasis and, for this reason, alteration in their activities has been associated with inflammatory diseases [1]. Indeed, studies of our research group have demonstrated alteration in the ectonucleotidase enzymes of lymphocytes in diseases that have inflammatory process involved in their pathology, such as hypertension [7], multiple sclerosis [26,30], HIV [19] and smoking [33]. Similarly, the inflammatory process appears to be a central mechanism in the pathophysiology of the MetS, since in central obesity the adipose tissue becomes metabolically active and releases different adipocytokines, which regulate immune-inflammatory function and may contribute to the development of chronic inflammation, insulin resistance and NAFLD [22,35].…”

Section: Discussion ▼mentioning

confidence: 99%

“…In accordance with these ideas, our results showed an increase in E-NTPDase activity to ATP and ADP hydrolysis and a decrease in ADA activity of lymphocytes from MetS patients, which may favor an immunosuppressive condition by increasing adenosine level. Indeed, some reports have demonstrated that these enzymatic behaviors in lymphocytes represent an important compensatory mechanism to reduce inflammation and immune response in diverse pathologies [7,19,26,30,33].…”

Section: Discussion ▼mentioning

confidence: 99%

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Exercise Training positively modulates the Ectonucleotidase Enzymes in Lymphocytes of Metabolic Syndrome Patients

et al. 2016

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In this study, we investigated the cardiovascular risk factors as well as ectonucleotidase activities in lymphocytes of metabolic syndrome (MetS) patients before and after an exercise intervention. 20 MetS patients, who performed regular concurrent exercise training for 30 weeks, 3 times/week, were studied. Anthropometric, biochemical, inflammatory and hepatic parameters and hydrolysis of adenine nucleotides and nucleoside in lymphocytes were collected from patients before and after 15 and 30 weeks of the exercise intervention as well as from participants of the control group. An increase in the hydrolysis of ATP and ADP, and a decrease in adenosine deamination in lymphocytes of MetS patients before the exercise intervention were observed (P<0.001). However, these alterations were reversed by exercise training after 30 weeks of intervention. Additionally, exercise training reduced the inflammatory and hepatic markers to baseline levels after 30 weeks of exercise. Our results clearly indicated alteration in ectonucleotidase enzymes in lymphocytes in the MetS, whereas regular exercise training had a protective effect on the enzymatic alterations and on inflammatory and hepatic parameters, especially if it is performed regularly and for a long period.

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Section: Discussion ▼supporting

confidence: 78%

Section: Discussion ▼mentioning

confidence: 99%

Section: Discussion ▼mentioning

confidence: 99%

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Exercise Training positively modulates the Ectonucleotidase Enzymes in Lymphocytes of Metabolic Syndrome Patients

et al. 2016

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“…Alterations of these parameters were minimized or returned by CR and EX. Several studies have showed beneficial effects of short-term CR and EX for reversing of these changes [16][17][18][19][20]. The human body also accumulates ROS that lead to tissue damage and decreased cardiovascular hemodynamic.…”

Section: Cardiovascular Hemodynamicmentioning

confidence: 99%

Combination of exercise and caloric restriction ameliorates nearly complete deleterious effects of aging on cardiovascular hemodynamic and antioxidant system parameters

Macit¹,

Üstündağ²,

Eyupoglu³

et al. 2020

jrp

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Aging is a progressive and catabolic process by cells of the body are broken down. Study scrutinized the effects of exercise and caloric restriction in cardiovascular hemodynamics and antioxidant system parameters. Rats divided to 5 categories as 1 control group (including 3 months aged animals) and 4 test groups (including 15 months aged animals) named by A-SED (aged-sedentary), A-CR (aged-caloric restricted), A-EX (aged-exercised) and A-CR-EX (aged-(exercised + caloric restricted)) created by adding carbachol (CAR) and phenylephrine (PE) cumulatively and during 6 weeks, 40% caloric restriction and swimming were administered to aged animals. At the beginning and end of study, blood pressure (BP) and ECHO of the animals were measured. After decapitation process, tissue (heart and aorta) samples were collected. In tissue samples, apoptotic and oxidative stress parameters, and in blood samples NO levels were studied. Additionally, tissues were viewed as histologically at light microscopy. GraphPad Prism 5v. program was used for statistics and p<0.05 were considered significantly. Contraction-relaxation responses of aorta improved after CR and EX administrations (p<0.05). In both tissues, oxidative stress parameters (8-OHdG, MDA, SOD, GSH), caspase-3 activity and caspase-3 dansity were recovered meaningfully (p<0.05). Finally, NO levels were significantly recovered with CR and EX administrations in aged animals (p<0.05). To sum up, it is suggested that CR and EX administrations contribute to the recovery of hemodynamic and antioxidant system parameters in aged rats.

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“…This fact can be explained because ATP, released from sympathetic nerves, along with norepinephrine (NE) and neuropeptide Y, can activate P2X receptors at postjunctional membranes evoking vascular smooth muscle contraction, which generally potentiate the effects of NE at α 1-adrenoceptors [ 51 , 80 ]. Accordingly, Cardoso et al have shown that E-NTPDase 1 expression and activity have the ability to control the effects of sympathetic nervous system in the vasculature [ 81 ].…”

Section: Noncommunicable Neurological and Degenerative Diseasesmentioning

confidence: 99%

The Impact of Purinergic System Enzymes on Noncommunicable, Neurological, and Degenerative Diseases

Bagatini

Santos

Cardoso

et al. 2018

Journal of Immunology Research

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Evidences show that purinergic signaling is involved in processes associated with health and disease, including noncommunicable, neurological, and degenerative diseases. These diseases strike from children to elderly and are generally characterized by progressive deterioration of cells, eventually leading to tissue or organ degeneration. These pathological conditions can be associated with disturbance in the signaling mediated by nucleotides and nucleosides of adenine, in expression or activity of extracellular ectonucleotidases and in activation of P2X and P2Y receptors. Among the best known of these diseases are atherosclerosis, hypertension, cancer, epilepsy, Alzheimer's disease (AD), Parkinson's disease (PD), and multiple sclerosis (MS). The currently available treatments present limited effectiveness and are mostly palliative. This review aims to present the role of purinergic signaling highlighting the ectonucleotidases E-NTPDase, E-NPP, E-5′-nucleotidase, and adenosine deaminase in noncommunicable, neurological, and degenerative diseases associated with the cardiovascular and central nervous systems and cancer. In conclusion, changes in the activity of ectonucleotidases were verified in all reviewed diseases. Although the role of ectonucleotidases still remains to be further investigated, evidences reviewed here can contribute to a better understanding of the molecular mechanisms of highly complex diseases, which majorly impact on patients' quality of life.

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Swimming training prevents alterations in ecto-NTPDase and adenosine deaminase activities in lymphocytes from Nω-nitro-L-arginine methyl ester hydrochloride induced hypertension rats

Abstract: These findings highlight the link between purinergic signalling and inflammatory process and suggest a novel mechanism in which moderate aerobic exercise possesses the potential to attenuate inflammation caused by hypertension.

Cited by 23 publications

References 41 publications

Exercise Training positively modulates the Ectonucleotidase Enzymes in Lymphocytes of Metabolic Syndrome Patients

Exercise Training positively modulates the Ectonucleotidase Enzymes in Lymphocytes of Metabolic Syndrome Patients

Combination of exercise and caloric restriction ameliorates nearly complete deleterious effects of aging on cardiovascular hemodynamic and antioxidant system parameters

The Impact of Purinergic System Enzymes on Noncommunicable, Neurological, and Degenerative Diseases

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