Swine Dysentery: The Influence of Dietary Selenium on Clinical and Pathological Effects of Treponema Hyodysenteriae Infection

Abstract

Twenty-four conventionally reared pigs divided into 4 groups were fed a basic ration deficient in selenium. The following daily supplement of selenium was given per pig; Group 1: none, group 2: 0.2 mg, group 3: 0.4 mg and group 4: 0.8 mg. After 51 days all pigs were inoculated orally with a pure culture of Treponema hyodysenteriae, and subsequently observed for 26 days. Clinical signs of swine dysentery were seen in all 4 groups. Criteria such as morbidity rate, incubation time and weight gain showed that the non-supplemented pigs suffered more severely from swine dysentery than the supplemented ones. Best protection was found among the pigs given a daily supplement of 0.4 mg selenium, whereas a supplement of 0.8 mg had a negative influence on the resistance to swine dysentery. The results indicate that selenium plays a more complex role in mucosal defence mechanisms than hitherto anticipated.swine dysentery ; selenium s u p p l e m e n t a t i o n ; T rep 0 n e m a h y 0 d Ysen t e ria e.

Selenium deficiency induced necroptosis, Th1/Th2 imbalance, and inflammatory responses in swine ileum

“…Se plays essential biological roles, such as immune promotion (Ahmadinezhad & Kaloghiros, 2016), anti‐inflammation (Combs, 2015), and antitumor roles (Muecke et al, 2018), in the growth and development of animals. Many studies have shown that the intestine is the target organ of Se and that Se can decrease the swine colon injury caused by dysentery (Teige, Larsen, & Tollersrud, 1984). In addition, Se participates in the regulation of intestinal inflammatory disease by affecting the expression of inflammatory factors (Massironi et al, 2013), and Se deficiency augments the risk of enteritis and cancer in mice (Barrett et al, 2013).…”

Calcium overload and reactive oxygen species accumulation induced by selenium deficiency promote autophagy in swine small intestine

“…These impacts have brought significant economic losses to the swine industry. Selenium can have a positive effect on intestinal function in swine, such as alleviating diarrhea-induced colitis injury ( Teige et al., 1984 ). As the small intestine is the main organ that absorbs Se ( Speckmann and Steinbrenner, 2014 ), the two are closely linked.…”

Selenium Speciation Analysis Reveals Improved Antioxidant Status in Finisher Pigs Fed l-Selenomethionine, Alone or Combined with Sodium Selenite, and Vitamin E

“…The fortification of animal diets with Se and VitE has been proven to improve growth and disease resistance in pigs [19][20][21]; yet, the uptake, accumulation and metabolic function will depend on the supplementation source and status of the animals [22,23]. The dietary Se requirement can be attained by enriching the feed with Se in an inorganic form, such as sodium selenite (Na 2 SeO 3 ), or with organic compounds, such as SeMet (2-amino-4-(methylselanyl)butanoic acid), but the total concentrations in the feed must be within legislated values.…”