Swine models for translational oncological research: an evolving landscape and regulatory considerations

Boettcher, Adeline N.; Schachtschneider, Kyle M.; Schook, Lawrence B.; Tuggle, Christopher K.

doi:10.1007/s00335-021-09907-y

Cited by 8 publications

(5 citation statements)

References 85 publications

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“…The use of established tumor cells can also reduce the study of the events underlying tumor formation and progression. Finally, the large dimensions make the use of adequate equipment necessary, with considerable costs [97].…”

Section: Porcine Modelsmentioning

confidence: 99%

Speeding up Glioblastoma Cancer Research: Highlighting the Zebrafish Xenograft Model

Alberti,

Amico,

Caruso Bavisotto

et al. 2024

IJMS

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Glioblastoma multiforme (GBM) is a very aggressive and lethal primary brain cancer in adults. The multifaceted nature of GBM pathogenesis, rising from complex interactions between cells and the tumor microenvironment (TME), has posed great treatment challenges. Despite significant scientific efforts, the prognosis for GBM remains very poor, even after intensive treatment with surgery, radiation, and chemotherapy. Efficient GBM management still requires the invention of innovative treatment strategies. There is a strong necessity to complete cancer in vitro studies and in vivo studies to properly evaluate the mechanisms of tumor progression within the complex TME. In recent years, the animal models used to study GBM tumors have evolved, achieving highly invasive GBM models able to provide key information on the molecular mechanisms of GBM onset. At present, the most commonly used animal models in GBM research are represented by mammalian models, such as mouse and canine ones. However, the latter present several limitations, such as high cost and time-consuming management, making them inappropriate for large-scale anticancer drug evaluation. In recent years, the zebrafish (Danio rerio) model has emerged as a valuable tool for studying GBM. It has shown great promise in preclinical studies due to numerous advantages, such as its small size, its ability to generate a large cohort of genetically identical offspring, and its rapid development, permitting more time- and cost-effective management and high-throughput drug screening when compared to mammalian models. Moreover, due to its transparent nature in early developmental stages and genetic and anatomical similarities with humans, it allows for translatable brain cancer research and related genetic screening and drug discovery. For this reason, the aim of the present review is to highlight the potential of relevant transgenic and xenograft zebrafish models and to compare them to the traditionally used animal models in GBM research.

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Section: Porcine Modelsmentioning

confidence: 99%

Speeding up Glioblastoma Cancer Research: Highlighting the Zebrafish Xenograft Model

Alberti,

Amico,

Caruso Bavisotto

et al. 2024

IJMS

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“…They are fully immune competent and possess more comparable immune constituents to the human immune system compared to murine models ( 43 , 44 ). Swine models can be applied in oncological research and are mostly used to test new devices and surgical procedures ( 45 ). Immunological applications can also be explored as swine are genetically and immunologically relevant to humans and have shown to respond similarly to anti-cancer drugs ( 46 ).…”

Section: Limited Relevant Preclinical Research Could Relate To Failin...mentioning

confidence: 99%

“…Immunological applications can also be explored as swine are genetically and immunologically relevant to humans and have shown to respond similarly to anti-cancer drugs ( 46 ). Different models exist such as genetically modified swine capable of developing tumors and wild-type immune competent swine bearing xenograft tumors ( 45 ). Lower models such as zebrafish or Xenopus could also provide opportunities to study certain therapeutic effects on cancer cells depending on the research question ( 44 ).…”

Section: Limited Relevant Preclinical Research Could Relate To Failin...mentioning

confidence: 99%

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Preclinical studies performed in appropriate models could help identify optimal timing of combined chemotherapy and immunotherapy

Berckmans,

Ceusters,

Vankerckhoven

et al. 2023

Front. Immunol.

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Immune checkpoint inhibitors (ICI) have been revolutionary in the field of cancer therapy. However, their success is limited to specific indications and cancer types. Recently, the combination treatment of ICI and chemotherapy has gained more attention to overcome this limitation. Unfortunately, many clinical trials testing these combinations have provided limited success. This can partly be attributed to an inadequate choice of preclinical models and the lack of scientific rationale to select the most effective immune-oncological combination. In this review, we have analyzed the existing preclinical evidence on this topic, which is only limitedly available. Furthermore, this preclinical data indicates that besides the selection of a specific drug and dose, also the sequence or order of the combination treatment influences the study outcome. Therefore, we conclude that the success of clinical combination trials could be enhanced by improving the preclinical set up, in order to identify the optimal treatment combination and schedule to enhance the anti-tumor immunity.

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“…Pigs have proven to be a useful model for biomedical device development and tumor ablation trials, especially in the context of designing human-sized instruments, improving surgical techniques and optimizing clinical procedures for use in humans [ 4 , 9 , 20 , 25 − 27 ]. However, to date, pig studies have focused on healthy tissue assessments and are limited to general safety evaluations.…”

Section: Introductionmentioning

confidence: 99%

Successful In Situ Targeting of Pancreatic Tumors in a Novel Orthotopic Porcine Model Using Histotripsy

Imran,

Gannon,

Morrison

et al. 2023

Ultrasound in Medicine & Biology

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Swine models for translational oncological research: an evolving landscape and regulatory considerations

Cited by 8 publications

References 85 publications

Speeding up Glioblastoma Cancer Research: Highlighting the Zebrafish Xenograft Model

Speeding up Glioblastoma Cancer Research: Highlighting the Zebrafish Xenograft Model

Preclinical studies performed in appropriate models could help identify optimal timing of combined chemotherapy and immunotherapy

Successful In Situ Targeting of Pancreatic Tumors in a Novel Orthotopic Porcine Model Using Histotripsy

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