“…For in vivo studies, experimental animal models, such as rodents (rat, mouse, guinea pig) or rabbits have been used first (Ballantyne and Marrs, 1992;Liu et al, 1999). More recently, in vivo approaches using the domestic pig have demonstrated a real interest of this model for CWA skin absorption studies (Dorandeu et al, 2007;Hawkins and Reifenrath, 1984;Simon and Maibach, 2000;Amitai et al, 2003;Chilcott et al, 2003Chilcott et al, , 2005bHamilton et al, 2004;Duncan et al, 2002;Van der Schans et al, 2003;Kadar et al, 2003). Nevertheless, the in vivo swine model showed many disadvantages, such as the supply and stabling of a large number of pigs or the handling of these animals.…”