Switch of tablet manufacturing from high shear granulation to twin-screw granulation using quality by design approach

Improvement of tabletability via twin-screw melt granulation: Focus on binder distribution

“…Similar results were found for wet granulation [107][108][109]. This was often explained with the higher density of the HSG granules, resulting in a poorer compactibility [107,109].…”

“…Having regard to literature, several studies comparing the performance of granules produced by wet granulation using TSG and HSG are available [107][108][109][110]. However, the product performances of granules produced either by TSMG or HSMG, where not yet compared.…”

Linking material properties to 1D-PBM parameters towards a generic model for twin-screw wet granulation

“…The effect of L/S ratio has been reported as much higher than that of SS and MFR in several lines of continuous wet granulation [25,26]. While a critical interaction between L/S ratio and MFR was reported in a different line [27], it was not relevant in the ConsiGmaTM-25 unit [28]. Experimental conditions were defined based on three steps.…”

Continuous twin screw granulation and fluid bed drying: A mechanistic scaling approach focusing optimal tablet properties

“…Out of that reason, one additional driver for the transition from batch to continuous manufacturing is the replacement of batch high shear wet granulation (= batchwise operating "equivalent" to TSG process) by twin screw wet granulation. Therefore, several researchers compared batchwise high shear granulation with the new continuous twin screw wet granulation technique [48,56,70,74] and found twin screw wet granulation performance to be equal or even better compared to batchwise high shear wet granulation.…”