Switchable cholesterol recognition system with Diels–Alder reaction using molecular imprinting technique on self‐assembled monolayer

Abstract

Molecular imprinting was conducted using a method to form a polymeric coating on a self‐assembled monolayer (SAM). This molecular imprinting system was able to obtain an on–off function using the Diels–Alder reaction. Cholesterol was used as a target compound and the SAM was formed using thiol compound on a gold plate. Epoxy resin was used to form the polymeric coating. Covalent bonding method was used in molecular imprinting. The formed molecular imprinting system recognized cholesterol better than analogs of cholesterol. Epoxy resin curing agent with furan group was synthesized to form the molecular imprinting system. Using the Diels–Alder reaction between the furan group and phenylmaleimide, this molecular imprinting system offers a switchable function. © 2019 Society of Chemical Industry

Modification of Silicone Hydrogel Contact Lenses for the Selective Adsorption of Ofloxacin

“…The molecularly imprinted bacterial cellulose exhibited approximately 1.6 times higher capability to bind to quercetin than the nonimprinted bacterial cellulose [23]. A molecular imprinting system offers a switchable function by using the Diels-Alder reaction between the furan group and phenyl maleimide [24].…”

Self-Assembled Plasmonic Nanojunctions Mediated by Host–Guest Interaction for Ultrasensitive Dual-Mode Detection of Cholesterol

“…5 Hence, the analysis of cholesterol levels is important for clinical biochemical examination and surveillance of diseases. Nowadays, many methods have been developed to analyze and monitor cholesterol in the human body such as colorimetry, 6 gas chromatography−mass spectrometry, 7 electrochemistry, 8 molecular imprinting, 9 etc. However, most of these methods relied on the use of enzymes related to cholesterol and had the timeconsuming processes.…”