Switchable electrode interfaces controlled by physical, chemical and biological signals

Bocharova, Vera; Katz, Evgeny

doi:10.1002/tcr.201100025

Cited by 47 publications

(30 citation statements)

References 112 publications

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“…[1][2][3][4][5][6][7] The integration of stimuli-responsive interfaces in these devices allows their operation as electrochemical gates, switching on and off or tuning the rate of the interfacial reaction to control and regulate mass transport, adhesive and, more importantly, electrochemical properties. [8][9][10][11][12][13] Herein, we aim to address the design and development of pH-encoded bio-catalysis by employing pH-responsive poly(4-vinyl pyridine) (P4VP) graphene oxide bio-interfaces ( pH Gr) to control and regulate enzyme-based molecular interaction.…”

Section: Introductionmentioning

confidence: 99%

pH-induced on/off-switchable graphene bioelectronics

2015

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Switchable interfaces can deliver functionally reversible reactivity with their corresponding analytes, which allows one to positively respond to the activity of biological elements, including enzymes and other biomolecules, through an encoded stimulus. We have realized this by the design of stimuli-responsive graphene interfaces for the pH-encoded operation of bioelectronics. Herein, we have demonstrated stimuli-responsive graphene interfaces for the pH-encoded operation of bioelectronics. The resulting switchable interfaces are capable of the highly specific, on-demand operation of biosensors, which has significant potential in a wide range of analytical applications.

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Section: Introductionmentioning

confidence: 99%

pH-induced on/off-switchable graphene bioelectronics

2015

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“…The azobenzene isomerizes by illumination with UV light ( = 300-400 nm) from the stable trans form to the cis state, while reverse isomerization can be triggered by irradiation with visible light ( = 425-500 nm). Isomerization of azobenzene is accompanied by an appreciable shape change as the trans isomer adopts a more linear conformation than the cis isomer [253]. When immobilized on surfaces and derivatized with single-stranded DNA, this change in molecular conformation has been able to reversibly control the hybridization and hence the functionality of the attached DNA ( Fig.…”

Section: Samsmentioning

confidence: 99%

Stimuli‐Responsive Surfaces in Biomedical Applications

Pranzetti¹,

Preece²,

Mendes³

2013

Intelligent Stimuli‐Responsive Materials

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Nature provides mechanisms that are able to dynamically control specific and nonspecific interactions between cells and biological surfaces [1,2]. Scientists have long tried to reproduce these dynamic biological events and have recently made an important step in that direction by creating artificial stimuli-responsive surfaces [3][4][5][6][7]. These smart substrates present modulatory surface properties that are able to respond to external chemical/biochemical [8][9][10][11][12], thermal [13][14][15], electrical [16][17][18][19][20], and optical stimuli [21][22][23][24][25][26][27][28][29][30][31]. Due to their dynamic nature such substrates are very appealing for applications in the biomedical field [32]. Progress to date has led to control over biomolecule activity [33] and immobilization of a diverse array of proteins, including enzymes [34] and antibodies [35]. These prior achievements have encouraged researchers to take the challenge of using dynamic surfaces to modulate larger and more complex systems, such as bacteria [36] and mammalian cells [37].Achieving control over surface properties could provide new insights in the understanding of cell behavior and can offer distinct benefits with regard to the development of medical devices. For instance, the modulation of cell attachment and detachment could lead to the prevention of unwanted bacteria fouling on implants, reducing the risk of infections and rejection [38][39][40][41][42]. Furthermore, dynamic surfaces able to present on demand regulatory signals to a cell could provide unprecedented opportunities in studies of cell responses in real-time. Cells in tissues adhere to and interact with their extracellular environment via specialized cell-cell and cell-extracellular

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“…For example, barriers to charge transport in biological matrices and electron transfer between redox proteins hinder the construction of efficient communication between biological materials and electronic components, and scaling up systems mimicking the complexity of biological systems for mass production, still await improved solutions. Many elegant discussions, reviews and valuable hypotheses have been published (Berlin et al 2001;Bocharova and Katz 2012;Davis and Higson 2005;Gray and Winkler 2003;Katz 2010;Katz et al 2012;Katz et al 2013;Katz and Pita 2009;Scott et al 2009;Shleev et al 2005) and researchers around the world have continuously strived to overcome these problems, but many of these ideas deserve separate discussion and fall out of the scope of the current review.…”

Section: Introductionmentioning

confidence: 95%

Switchable bioelectronics

Parlak

Turner

2016

Biosensors and Bioelectronics

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We review the rapidly emerging field of switchable interfaces and its implications for bioelectronics. We seek to piece together early breakthroughs and key developments, and highlight and discuss the future of switchable bioelectronics by focusing on bio-electrochemical processes based on mimicking and controlling biological environments with external stimuli. All these studies strive to answer a fundamental question: "how do living systems probe and respond to their surroundings? And, following on from that: "how one can transform these concepts to serve the practical world of bioelectronics?" The central obstacle to this vision is the absence of versatile interfaces that are able to control and regulate the means of communication between biological and electronic systems. Here, we review the overall progress made to date in building such interfaces at the level of individual biomolecules and focus on the latest efforts to generate device platforms that integrate bio-interfaces with electronics.

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Switchable electrode interfaces controlled by physical, chemical and biological signals

Cited by 47 publications

References 112 publications

pH-induced on/off-switchable graphene bioelectronics

pH-induced on/off-switchable graphene bioelectronics

Stimuli‐Responsive Surfaces in Biomedical Applications

Switchable bioelectronics

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