Switchable electrosynthesis of furoquinones in batch and continuous-flow modes

Abstract

A straightforwardly switchable electrosynthesis of non-deamination and deamination furoquinones under catalyst- and oxidant-free conditions was developed. The scale up investigations were carried out in batch and continuous-flow. Dramatic decrease of...

Difunctionalization of alkenes proceeding with radical 1,2-alkynyl migration in batch and continuous-flow modes

“…[17][18][19][20] The use of a continuousflow process could overcome these limitations and significantly improve the efficiency of electrochemical difunctionalization of alkenes, leading to shorter reaction times and higher productivity. [21][22][23][24][25] With our continued interest in continuous-flow electrosynthesis and radical-promoted electrochemical intramolecular migration reactions, an approach for electrosynthesis of a-alkynyl ketones through the difunctionalization of 1,4enynes under catalyst and oxidant-free conditions in batch and continuous-flow modes was developed (Scheme 1d).…”

“…17–20 The use of a continuous-flow process could overcome these limitations and significantly improve the efficiency of electrochemical difunctionalization of alkenes, leading to shorter reaction times and higher productivity. 21–25…”

Electrosynthesis of Highly Functionalized Polycyclic N-Heteroaromatics through Cascade Radical Cyclization and Alkoxylation in Batch and Continuous-Flow

“…Organic electrochemistry, employing “electrons” as traceless “reagents” to promote redox reactions, has been recognized as a more green and practical synthetic technology, which avoids the use of exogenous oxidants and reductants. − Moreover, the electrolysis process uses a controlled potential and can be switched-off anytime easily. − In this regard, electro-oxidative radical cascade cyclization to a series of highly functionalized PNAs in the absence of exogenous oxidants or reductants has attracted wide interest and research. − In particular, Xu and co-workers reported some straightforward preparation of PNAs through intramolecular cascade cyclization from an N-centered radical which was generated from anodic oxidation. − Besides, some electrochemical intermolecular radical addition onto alkynes or alkenes and cyclization to PNAs were developed. − Furthermore, the highly functionalized PNAs could also be generated from electrochemical oxidative π-extension of unfunctionalized heterobiaryl compounds via the radical cyclization processes. − We had also reported the electrosynthesis of PNAs from N, , C, − S, , or halogen radical intermediates.…”