Switchable PDT for reducing skin photosensitization by a NIR dye inducing self-assembled and photo-disassembled nanoparticles

Zhang, Yifan; He, Lingyi; Wu, Jie; Wang, Kaikai; Wang, Juan; Dai, Wei‐Min; Yuan, Ahu; Wu, Jinhui; Hu, Yiqiao

doi:10.1016/j.biomaterials.2016.08.037

Cited by 89 publications

(58 citation statements)

References 28 publications

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“…The photoactivity of the photosensitizer can also be modulated by conjugation with a quencher molecule different from the photosensitizer itself. IR780 could be used as a quencher of chlorin-e6 fluorescence in albumin-based nanosystems [107]. Upon NIR excitation and IR780 degradation chlorin-e6 is activated.…”

Section: Covalent Conjugation Of Photosensitizersmentioning

confidence: 99%

Rational design of block copolymer self-assemblies in photodynamic therapy

Demazeau¹,

Gibot²,

Mingotaud³

et al. 2020

Beilstein J. Nanotechnol.

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Photodynamic therapy is a technique already used in ophthalmology or oncology. It is based on the local production of reactive oxygen species through an energy transfer from an excited photosensitizer to oxygen present in the biological tissue. This review first presents an update, mainly covering the last five years, regarding the block copolymers used as nanovectors for the delivery of the photosensitizer. In particular, we describe the chemical nature and structure of the block copolymers showing a very large range of existing systems, spanning from natural polymers such as proteins or polysaccharides to synthetic ones such as polyesters or polyacrylates. A second part focuses on important parameters for their design and the improvement of their efficiency. Finally, particular attention has been paid to the question of nanocarrier internalization and interaction with membranes (both biomimetic and cellular), and the importance of intracellular targeting has been addressed.

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Section: Covalent Conjugation Of Photosensitizersmentioning

confidence: 99%

Rational design of block copolymer self-assemblies in photodynamic therapy

Demazeau¹,

Gibot²,

Mingotaud³

et al. 2020

Beilstein J. Nanotechnol.

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“…Meanwhile, the ideal AIE active fluorogens also show far red/NIR fluorescence with large Stokes shifts, which are highly desirable for optical bioimaging [40]. These unique characteristics enable a great potential for image-guided PDT by encapsulation of AIE active fluorophores by polymer matrix to provide platform with NIR fluorescence for bioimaging [3], ROS production for ablation [41], negligible dark toxicity [42], good photostability [41], and biocompatibility [44]. For example, NIR AIE active probe containing tetraphenyl ethene (TPE) as electron donor and dicyanovinyl (DC) as acceptor, TPETCAQ, is encapsulated by DSPE to yield organic fluorescent nanoparticles for image-guided PDT [41].…”

Section: Ivyspringmentioning

confidence: 99%

“…Rhodanine [42] (1.21 g, 5 mmol), TPVT-CHO (1.83 g, 5 mmol), and NH 4 Ac (500 mg) were added in HOAc (20 ml) under N 2 atmosphere. The resulting mixture was stirred at 120 C for 12 h. After cooling to room temperature,the precipitate was collected and washed with cold MeOH.…”

Section: Synthesis Of Tpvtrmentioning

confidence: 99%

Near-Infrared Organic Fluorescent Nanoparticles for Long-term Monitoring and Photodynamic Therapy of Cancer

Qi¹,

Chen²,

Zhou³

et al. 2019

Nanotheranostics

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Photodynamic therapy (PDT), which utilizes reactive oxygen species to ablate tumor, has attracted much attention in recent years. Photosensitizers with near-infrared (NIR) fluorescence as well as efficient ROS generation ability have been used for precise diagnosis and simultaneous treatment of cancer. However, photosensitizers frequently suffer from low ROS generation ability and NIR fluorescence quenching in aqueous media due to the aggregation. Methods: We prepare an effective AIE active NIR emissive photosensitizer containing rhodanine as electron acceptor and triphenylvinylthiophene as electron donor is prepared, and encapsulate the corresponding photosensitizer into Pluronic F127 to fabricate NIR organic fluorescent nanoparticles. We then evaluate the NIR fluorescence bioimaging and photodynamic therapy ability of TPVTR dots in vitro and in vivo. Results: The yielded organic fluorescent nanoparticles exhibit effective ROS generation ability, bright NIR emission, high photostability, and good biocompatibility. Both in vitro and in vivo experiments confirm that NIR organic fluorescent nanoparticles demonstrate good performances in long-term tracing and photodynamic ablation of tumor. Conclusion: In summary, the synthesized organic fluorescent nanoparticles, TPVTR dots, showed great potentials in long-term cell tracing and photodynamic therapy of tumor. Our study highlights the efficient strategy for developing promising near-infrared organic fluorescent nanoparticles in advancing the field of bioimaging and further image-guide clinical applications.

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“…1,2 Photosensitizers (PSs) are an essential component of PDT, which generate reactive oxygen species (ROS) to kill tumor cells when excited by light irradiation. 3,4 Although some PSs have been approved by the Food and Drug Administration (FDA), the clinical applications of PDT are still impeded by the poor water solubility and nonspecic distribution in vivo of PSs. 5 Therefore, it is highly desirable to develop new platforms as PS carriers for PDT, with good solubility, tumor-targeting ability and biocompatibility.…”

Section: Introductionmentioning

confidence: 99%