Switchable release nano-reservoirs for co-delivery of drugs via a facile micelle–hydrogel composite

Patel, Monika; Kaneko, Tatsuo; Matsumura, Kazuaki

doi:10.1039/c7tb00701a

Cited by 31 publications

(22 citation statements)

References 69 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…4.5), PGA chains in the PGA‐PPA micelles become relatively un‐charged and acquire a helical conformation, which strains the core of the micelle and results in faster release of the drug. This is required for the initial prevention of infection at the site of wounding . On the other hand; PLL–PPA micelles in the composite exist in charged random‐coil state.…”

Section: Discussionmentioning

confidence: 99%

“…The dual‐drug‐loaded micelle–hydrogel composites were generated by using poly (l‐ lysine‐ b ‐phenylalanine) and poly(glutamic acid‐ b ‐phenylalanine) (Scheme S1) polymers, as previously described (Supporting Information). The polymers were synthesized using the common N ‐carboxyanhydride (NCA) method.…”

Section: Methodsmentioning

confidence: 99%

“…We recently reported preparation of a new micelle–hydrogel composite . The composite consists of polypeptide micelles cross‐linked with genipin, both of which are biocompatible and frequently used for medical purposes.…”

Section: Introductionmentioning

confidence: 99%

“…Because of the presence of amphiphilic polypeptide chains, these polypeptides easily self‐assemble into micelles, rendering drug loading of the hydrophobic core effortless and facile. In a previous study, we showed that these micelle systems release drugs under various conditions . Because of the opposite charge of the micelles in the composite, the two micellar systems behave differently at varying pH values, hence enabling various drug release rates.…”

Section: Introductionmentioning

confidence: 99%

“…We recently reported preparation of a new micellehydrogel composite. 37 The composite consists of polypeptide micelles cross-linked with genipin, both of which are biocompatible and frequently used for medical purposes. The micellehydrogel composite is composed of two oppositely charged polypeptide-based micelle systems, the positively charged poly (L-lysine)-b-poly(phenylalanine) (PLL-PPA), and negatively charged poly(glutamic acid)-b-poly(phenylalanine) (PGA-PPA).…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Effect of dual‐drug‐releasing micelle–hydrogel composite on wound healing in vivo in full‐thickness excision wound rat model

Patel

Nakaji-Hirabayashi

Matsumura

2019

J Biomedical Materials Res

Self Cite

View full text Add to dashboard Cite

Wound healing is a complex process involving an intricate cascade of body responses. A composite dressing that would effectively target different stages of wound healing and regeneration is urgently needed. In the current study, we tested the efficacy of a previously prepared micelle–hydrogel composite loaded with two drugs, in full‐thickness excision wound model in rat. We found that the composite elicited almost no inflammation and effectively enhanced healing at all stages of the healing process. An initial burst of the first drug, amphotericin B, eliminated any preliminary infection. This burst was followed by a gradual release of curcumin as the healing and anti‐inflammatory agent. Better healing was observed in rats treated with the drug‐loaded composites than in blank and control groups. Wounds showed up to 80% closure in the treated group, with high collagen deposition. Re‐epithelialization and granulation were also better in the treated group than in the non‐treated control and blank groups. Histopathological examination revealed that drug‐loaded composites improved cutaneous wound healing and regeneration. In conclusion, the micelle–hydrogel composite is an effective dressing and might have major applications in wound healing. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 107A: 1094–1106, 2019.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Effect of dual‐drug‐releasing micelle–hydrogel composite on wound healing in vivo in full‐thickness excision wound rat model

Patel

Nakaji-Hirabayashi

Matsumura

2019

J Biomedical Materials Res

Self Cite

View full text Add to dashboard Cite

show abstract

Triboelectric‐Responsive Drug Delivery Hydrogel for Accelerating Infected Wound Healing

Qin,

Shi,

Wen

et al. 2024

Adv Healthcare Materials

View full text Add to dashboard Cite

Electrotherapy is of great interest in the field of tissue repair as an effective, well‐tolerated and noninvasive treatment. Triboelectric nanogenerator (TENG) has shown advantages in promoting wound healing due to its peak output characteristic and low Joule heating effect. However, it is limited in infected wound healing due to poor antimicrobial capacity. Here, we developed a wearable triboelectric stimulator (WTS) that consists of a flexible TENG (F‐TENG) and a triboelectric‐responsive drug delivery hydrogel (TR‐DDH) for healing of bacterium‐infected wounds. F‐TENG can generate pulsed current to wounds by converting mechanical energy from body movements. Polypyrrole is prone to reduction and volume contraction under electrical stimulation, resulting in desorption of curcumin nanoparticles (CUR NPs) from the polypyrrole in TR‐DDH. Therefore, the highly efficient and controllable release of CUR NPs can be achieved by triboelectric stimulation. According to the in vitro and in vivo experiments, WTS had the greatest antimicrobial effect and fastest promotion of infected wound healing compared to treatment with electrical stimulation or curcumin. Finally, the safety assessment demonstrated that the WTS has excellent tissue safety for chronic wound healing. Synergistic therapy with WTS provides an efficient strategy for chronic wound healing and smart‐responsive drug delivery systems.This article is protected by copyright. All rights reserved

show abstract

Multicompartment Hydrogels

Schmidt

2022

Macromol. Rapid Commun.

View full text Add to dashboard Cite

Hydrogels belong to the most promising materials in polymer and materials science at the moment. As they feature soft and tissue-like character as well as high water-content, a broad range of applications are addressed with hydrogels, e.g., tissue engineering and wound dressings but also soft robotics, drug delivery, actuators, and catalysis. Ways to tailor hydrogel properties are crosslinking mechanisms, hydrogel shape, and reinforcement, but new features can be introduced by variation of hydrogel composition as well, e.g., via monomer choice, functionalization or compartmentalization. In particular, multicompartment hydrogels drive progress toward complex and highly functional soft materials. In the present review the latest developments in multicompartment hydrogels are highlighted with a focus on three types of compartments; micellar/vesicular, droplets, and multilayers including various subcategories. Furthermore, several morphologies of compartmentalized hydrogels and applications of multicompartment hydrogels will be discussed as well. Finally, an outlook toward future developments of the field will be given. The further development of multicompartment hydrogels is highly relevant for a broad range of applications and will have a significant impact on biomedicine and organic devices.

show abstract

Switchable release nano-reservoirs for co-delivery of drugs via a facile micelle–hydrogel composite

Cited by 31 publications

References 69 publications

Effect of dual‐drug‐releasing micelle–hydrogel composite on wound healing in vivo in full‐thickness excision wound rat model

Effect of dual‐drug‐releasing micelle–hydrogel composite on wound healing in vivo in full‐thickness excision wound rat model

Triboelectric‐Responsive Drug Delivery Hydrogel for Accelerating Infected Wound Healing

Multicompartment Hydrogels

Contact Info

Product

Resources

About