Pressurized artificial muscles are reviewed. These actuators consist of stiff reinforcing fibers surrounding an elastomeric bladder and operate using a pressurized internal fluid. The pressurized artificial muscles, known as McKibben actuators or flexible matrix composite actuators, can be applied to a wide array of applications, including prosthetics/orthotics, robots, morphing wing technologies, and variable stiffness structures. Analytical models for predicting the response behavior have used both virtual work methods and continuum mechanics. Various nonlinear control algorithms have been developed, including sliding mode control (SMC), adaptive control, neural networks, etc. In addition to traditional fluid-driving methods, innovative techniques such as chemical and electrical driving techniques are reviewed. With improved manufacturing techniques, the operational life of pressurized artificial muscles has been significantly extended, thus making them suitable for a vast range of potential applications.