1995
DOI: 10.1016/0092-8674(95)90056-x
|View full text |Cite
|
Sign up to set email alerts
|

Switches in expression of plasmodium falciparum var genes correlate with changes in antigenic and cytoadherent phenotypes of infected erythrocytes

Abstract: Plasmodium falciparum expresses on the host erythrocyte surface clonally variant antigens and ligands that mediate adherence to endothelial receptors. Both are central to pathogenesis, since they allow chronicity of infection and lead to concentration of infected erythrocytes in cerebral vessels. Here we show that expression of variant antigenic determinants is correlated with expression of individual members of a large, multigene family named var. Each var gene contains copies of a motif that has been previou… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1

Citation Types

1
647
0
4

Year Published

1996
1996
2008
2008

Publication Types

Select...
8
2

Relationship

0
10

Authors

Journals

citations
Cited by 942 publications
(652 citation statements)
references
References 48 publications
(93 reference statements)
1
647
0
4
Order By: Relevance
“…Recently three labs have independently cloned the gene for a highly variable knob antigen called as P falciparum erythrocyte membrane protein-I (PFEMP-1) [10][11][12]. It has been speculated that the C-terminal acidic domain of PFEMP-1 must be interacting with the positively charged KAHRP through salt bridges [11].…”
Section: Discussionmentioning
confidence: 99%
“…Recently three labs have independently cloned the gene for a highly variable knob antigen called as P falciparum erythrocyte membrane protein-I (PFEMP-1) [10][11][12]. It has been speculated that the C-terminal acidic domain of PFEMP-1 must be interacting with the positively charged KAHRP through salt bridges [11].…”
Section: Discussionmentioning
confidence: 99%
“…These antigens are highly variable both between parasite clones and within clones owing to an antigenic switching mechanism. This variability is afforded by the multiple copies in the genome of their coding gene, denoted var (Baruch et al 1995;Smith et al 1995;Su et al 1995). These antigens are recognized by the immune system in a highly variantspecific way (Marsh & Howard 1986;Forsyth et al 1989;Newbold et al 1992;Iqbal et al 1993;Reeder et al 1994;Giha et al 1998;Bull et al 1999;Giha et al 1999;Nielsen et al 2002;Ofori et al 2002) although there appears to be some cross-reactivity between variants (Aguiar et al 1992;Chattopadhyay et al 2003).…”
Section: (B) Antigenic Variationmentioning
confidence: 99%
“…The subsequent accumulation of infected RBCs in the microvasculature is largely responsible for malaria-associated morbidity and mortality. This sequestration of IRBCs is mediated by the parasite protein P. falciparum erythrocyte membrane protein 1 (PfEMP-1), which is exported to the surface of the IRBCs and is encoded by a family of variant antigens (Baruch et al, 1995;Smith et al, 1995;Su et al, 1995). Because human RBCs are devoid of a functional protein trafficking system, the parasite has to establish a protein export system in the host cell before PfEMP-1 can be displayed on the surface of the infected cell.…”
mentioning
confidence: 99%