Switching Cancers: A Systematic Review Assessing the Role of Androgen Suppressive Therapy in Bladder Cancer

Kourbanhoussen, Kassim; McMartin, Catherine; Lodde, Michele; Zlotta, Alexandre R.; Bryan, Richard T.; Toren, Paul

doi:10.1016/j.euf.2020.10.002

Cited by 15 publications

(18 citation statements)

References 50 publications

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“…Although sample size was small and follow-up time was short, this study suggests that ADT or dutasteride may prevent UBC recurrence in high risk patients. In patients already diagnosed with UBC, retrospective studies have suggest that both overall and cancer-specific survival were superior in 5α-reductase inhibitor users [ 59 ]. ADT may protect UBC with low-risk disease, but not patients with high-risk disease [ 59 ].…”

Section: Ubc As An Endocrine Tumormentioning

confidence: 99%

“…In patients already diagnosed with UBC, retrospective studies have suggest that both overall and cancer-specific survival were superior in 5α-reductase inhibitor users [ 59 ]. ADT may protect UBC with low-risk disease, but not patients with high-risk disease [ 59 ]. This correlates with declining AR expression by more advanced UBC tumors [ 40 , 50 ].…”

Section: Ubc As An Endocrine Tumormentioning

confidence: 99%

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Gender Differences in Urothelial Bladder Cancer: Effects of Natural Killer Lymphocyte Immunity

Livas

Presnell

Sexton

et al. 2021

JCM

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Men are more likely to develop cancer than women. In fact, male predominance is one of the most consistent cancer epidemiology findings. Additionally, men have a poorer prognosis and an increased risk of secondary malignancies compared to women. These differences have been investigated in order to better understand cancer and to better treat both men and women. In this review, we discuss factors that may cause this gender difference, focusing on urothelial bladder cancer (UBC) pathogenesis. We consider physiological factors that may cause higher male cancer rates, including differences in X chromosome gene expression. We discuss how androgens may promote bladder cancer development directly by stimulating bladder urothelium and indirectly by suppressing immunity. We are particularly interested in the role of natural killer (NK) cells in anti-cancer immunity.

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Section: Ubc As An Endocrine Tumormentioning

confidence: 99%

Section: Ubc As An Endocrine Tumormentioning

confidence: 99%

Gender Differences in Urothelial Bladder Cancer: Effects of Natural Killer Lymphocyte Immunity

Livas

Presnell

Sexton

et al. 2021

JCM

View full text Add to dashboard Cite

show abstract

“…Although sample size was small and follow-up time was short, this study suggests that ADT or dutasteride may prevent UBC recurrence in high risk patients. In patients already diagnosed with UBC, retrospective studies suggest that both overall and cancer-specific survival were superior in 5α-reductase inhibitor users [68]. ADT may protect UBC with low-risk disease, but not patients with high risk disease [68].…”

Section: Ubc As An Endocrine Tumormentioning

confidence: 99%

“…In patients already diagnosed with UBC, retrospective studies suggest that both overall and cancer-specific survival were superior in 5α-reductase inhibitor users [68]. ADT may protect UBC with low-risk disease, but not patients with high risk disease [68]. This correlates with declining AR expression by more advanced UBC tumors [49,59].…”

Section: Ubc As An Endocrine Tumormentioning

confidence: 99%

“…Interestingly, amplification of the gene that encodes 5α-reductase was found in 12% of UBC queried in the TCGA database [70]. In a systemic review, ADT or 5α-reductase inhibitors had mixed results in preventing UBC [68]. Interpretation of these studies is difficult because of the expected lower complications of urinary tract infection and hematuria in 5α-reductase inhibitor users may have led to fewer exploratory cystoscopies and therefore fewer incidental UBC diagnoses.…”

Section: Ubc As An Endocrine Tumormentioning

confidence: 99%

See 1 more Smart Citation

Gender Differences in Urothelial Bladder Cancer. Effects of Natural Killer Lymphocyte Immunity

Livas

Presnell

Sexton

et al. 2021

Preprint

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Men are more likely to develop cancer than women. In fact, male predominance is one of the most consistent cancer epidemiology findings. Additionally, men have a poorer prognosis and an increased risk of secondary malignancies compared to women. These differences have been investigated in order to better understand cancer and to better treat both men and women. In this review, we discuss factors that may cause this gender difference, focusing on urothelial bladder cancer (UBC) pathogenesis. We consider physiological factors that may cause higher male cancer rates, including differences in X chromosome gene expression. We discuss how androgens may promote bladder cancer development directly by stimulating bladder urothelium and indirectly by suppressing immunity. We are particularly interested in natural killer (NK) cells because they are important, but often overlooked anti-cancer lymphocytes.

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Dietary fats and their sources in association with the risk of bladder cancer: A pooled analysis of 11 prospective cohort studies

Dianatinasab

Wesselius

Salehi‐Abargouei

et al. 2022

Intl Journal of Cancer

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The effects of fat intake from different dietary sources on bladder cancer (BC) risk remains unidentified. Therefore, the present study aimed to investigate the association between fat intakes and BC risk by merging world data on this topic. Data from 11 cohort studies in the BLadder cancer Epidemiology and Nutritional Determinants (BLEND) study, provided sufficient information on fat intake for a total of 2731 BC cases and 544 452 noncases, which yielded 5 400 168 person-years of follow-up. Hazard ratios (HRs), with corresponding 95% confidence intervals (CIs), were estimated using Cox-regression models stratified on cohort. Analyses were adjusted for total energy intake in kilocalories, gender, smoking status (model-1) and additionally for sugar and sugar products, beers, wine, dressing and plantbased and fruits intakes (model-2). Among women, an inverse association was

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Switching Cancers: A Systematic Review Assessing the Role of Androgen Suppressive Therapy in Bladder Cancer

Cited by 15 publications

References 50 publications

Gender Differences in Urothelial Bladder Cancer: Effects of Natural Killer Lymphocyte Immunity

Gender Differences in Urothelial Bladder Cancer: Effects of Natural Killer Lymphocyte Immunity

Gender Differences in Urothelial Bladder Cancer. Effects of Natural Killer Lymphocyte Immunity

Dietary fats and their sources in association with the risk of bladder cancer: A pooled analysis of 11 prospective cohort studies

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