Switching Clozapine Responders to Olanzapine

Blood pressure changes during clozapine or olanzapine treatment in Korean schizophrenic patients

“…Clozapine-induced hypertension was reported by Ereshefsky et al (1989). In an open-label study conducted to determine the effectiveness and safety of a method of slow crosstitration from clozapine to olanzapine with 20 patients (Littrell et al 2000), three cases of clozapine-induced hypertension (15%) were reported. While this rate appears elevated, there was no comparison group available to directly test the effect of clozapine.…”

Switching patients to aripiprazole from other antipsychotic agents: a multicenter randomized study

“…In addition, variations are observed between patients in their tolerability to different atypical agents. For example, studies involving patients responsive to clozapine treatment but experiencing medication-induced adverse events have shown that switching to olanzapine can reduce druginduced side effects while maintaining symptom control (Littrell et al 2000).…”

Response to clozapine following failure to respond to olanzapine

“…It is of interest to note that response rates of between 50 per cent 31 and 90 per cent 32 are reported in patients switching from clozapine to olanzapine.…”