The final design is a process optimisation for batch-produced PFSS, based on circular strategies such as reduce, reuse, rethink and repurpose. Interventions include: eliminating the first sterilisation phase, reduce left-over medication and change from steam to gamma sterilisation. The proposed interventions have been evaluated by discussion.In the end, the environmental impact of syringes is reduced by optimising the filling process, which resulted in decreasing the amount of waste, material, energy and water usage, while remaining safe and without increasing the workload of the staff of the ICU.