Switching from tobacco cigarettes in very early pregnancy: The effects of in utero e-cigarette exposure on mouse offspring neurodevelopment and behaviour

Bakker, Chloe; Chivers, Emily K.; Chia, Xian-Wen; Quintrell, Ebony; Wyrwoll, Caitlin; Larcombe, Alexander N.

doi:10.1016/j.physbeh.2023.114118

Cited by 3 publications

(2 citation statements)

References 49 publications

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“…The rise in popularity of these devices can be attributed to the belief that electronic nicotine delivery systems are a safer alternative to smoking traditional tobacco cigarettes [1]. Some individuals may even switch to using electronic nicotine delivery systems during pregnancy as opposed to cigarette smoking due to the perceived harm reduction or choice to use both cigarettes and electronic nicotine delivery systems together [2]. This rise in the use of electronic nicotine delivery systems in pregnant users and the general population implicates the need for further research into the effects of prenatal nicotine exposure (PNE).…”

Section: Introductionmentioning

confidence: 99%

Effects of Prenatal Nicotine Exposure on Short-Term and Long-Term Memory: A Literature Review

Mason

2024

URNCST Journal

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Section: Introductionmentioning

confidence: 99%

Effects of Prenatal Nicotine Exposure on Short-Term and Long-Term Memory: A Literature Review

Mason

2024

URNCST Journal

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“…Moreover, exposure to e-cigs exhibited potentially harmful neurodevelopmental effects during early pregnancy or early-life exposure. For example, maternal exposure to e-cigs containing nicotine had been shown to increase offspring bodyweight and impair motor skill learning [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

Altered insular functional activity among electronic cigarettes users with nicotine dependence

Sun,

Xie,

Fang

et al. 2024

Transl Psychiatry

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Electronic cigarettes (e-cigs) use, especially among youngsters, has been on the rise in recent years. However, little is known about the long-term effects of the use of e-cigs on brain functional activity. We acquired the resting-state functional magnetic resonance imaging (rs-fMRI) data from 93 e-cigs users with nicotine dependence and 103 health controls (HC). The local synchronization was analyzed via the regional homogeneity (ReHo) method at voxel-wise level. The functional connectivity (FC) between the nucleus accumbens (NAcc), the ventral tegmental area (VTA), and the insula was calculated at ROI-wise level. The support vector machining classification model based on rs-fMRI measures was used to identify e-cigs users from HC. Compared with HC, nicotine-dependent e-cigs users showed increased ReHo in the right rolandic operculum and the right insula (p < 0.05, FDR corrected). At the ROI-wise level, abnormal FCs between the NAcc, the VTA, and the insula were found in e-cigs users compared to HC (p < 0.05, FDR corrected). Correlation analysis found a significant negative correlation between ReHo in the left NAcc and duration of e-cigs use (r = −0.273, p = 0.008, FDR corrected). The following support vector machine model based on significant results of rs-fMRI successfully differentiates chronic e-cigs users from HC with an accuracy of 73.47%, an AUC of 0.781, a sensitivity of 67.74%, and a specificity of 78.64%. Dysregulated spontaneous activity and FC of addiction-related regions were found in e-cigs users with nicotine dependence, which provides crucial insights into the prevention of its initial use and intervention for quitting e-cigs.

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Nicotine and Vape: Drugs of the Same Profile Flock Together

Otenaike,

Farodoye,

de Silva

et al. 2024

J Biochem & Molecular Tox

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Smoking, a major behavioral health burden, causes preventable and premature deaths globally. Nicotine, the addictive component present in tobacco products and Electronic cigarettes (E‐cigarettes, vape), can bind to nicotinic acetylcholine receptors in the brain to trigger a dopamine release that reinforces smoking. Despite the widespread usage of nicotine, its mechanisms of toxicity, particularly in e‐cigarettes, are poorly understood. Using Drosophila melanogaster as a model organism, this study aims to investigate the mechanism of the toxicity of nicotine and vape. Behavioral parameters, oxidative stress indicators, mRNA expression levels of Dopamine 1‐ receptor 1 (Dop1R1), Acetyl‐coenzyme A synthetase (AcCoAs), and apoptotic proteins were assessed in the flies after a 5‐day exposure to varying concentrations of nicotine (0.15, 0.25, and 0.35 mg/mL diet) and vape (0.06, 0.08, and 0.12 mg/mL diet). Furthermore, Gas Chromatography‐Mass Spectrometry (GC/MS) and Gas Chromatography‐Flame Ionization Detection (GC/FID) analyzes were conducted to gain more insight on the composition of the vape used in study. Findings indicate that both nicotine and vape exposure significantly reduced lifespan, impaired locomotor activity, and disrupted sleep patterns. Notably, nicotine exposure stimulated Dop1R1 transcription and altered Acetyl‐CoA gene expression, impacting the viability and behavior of the flies. Elevated levels of reactive oxygen biomarkers were observed, contributing to cellular damage through oxidative stress and apoptotic mechanisms mediated by the Reaper and DIAP1 proteins. Additionally, the composition analysis of vape liquid revealed the presence of propylene glycol, nicotine, methyl esters, and an unidentified compound. This study highlights the complex interplay between nicotine, gene expression, and physiological responses in Drosophila.

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Switching from tobacco cigarettes in very early pregnancy: The effects of in utero e-cigarette exposure on mouse offspring neurodevelopment and behaviour

Cited by 3 publications

References 49 publications

Effects of Prenatal Nicotine Exposure on Short-Term and Long-Term Memory: A Literature Review

Effects of Prenatal Nicotine Exposure on Short-Term and Long-Term Memory: A Literature Review

Altered insular functional activity among electronic cigarettes users with nicotine dependence

Nicotine and Vape: Drugs of the Same Profile Flock Together

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