Switching of Glucose Metabolism from Oxidative Phosphorylation to Aerobic Glycolysis (the Warburg Effect) in T-Cells from Patients with Asthma

Ostroukhova, Marina; Qiang, Liang; Goplen, N.; Alam, R.

doi:10.1016/j.jaci.2009.12.187

Cited by 5 publications

(1 citation statement)

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“…Metabolic rewiring in T-cells towards glycolysis can be driven by cytokines and has been long recognized as a central feature of T-cell effector polarization, [78][79][80][81] while more recent studies have begun to explore the drivers and consequences of metabolic reprogramming in airway EpCs. 53,82 To understand how the local cytokine milieu influences glycolysis in airway EpCs, we analyzed an external bulk RNA-seq dataset of human bronchial EpC (HBEC) air-liquid interface (ALI) cultures which were stimulated with IFN-α, IFN-γ, IL-13, We utilized the top 200 genes induced by each cytokine in HBEC ALIs as cytokine response signatures with which we scored basal EpCs in our in vivo dataset using GSVA (Table E10).…”

Section: Epithelial Glycolysis Can Be Induced By T2 and T17 Cytokines...mentioning

confidence: 99%

Increased epithelial mTORC1 activity in chronic rhinosinusitis with nasal polyps

Huang,

Hallen,

Lee

et al. 2023

Preprint

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Background: The airway epithelium plays a central role in the pathogenesis of chronic respiratory diseases such as asthma and chronic rhinosinusitis with nasal polyps (CRSwNP), but the mechanisms by which airway epithelial cells (EpCs) maintain inflammation are poorly understood. Objective: We hypothesized that transcriptomic assessment of sorted airway EpCs across the spectrum of differentiation would allow us to define mechanisms by which EpCs perpetuate airway inflammation. Methods: Ethmoid sinus EpCs from adult patients with CRS were sorted into 3 subsets, bulk RNA sequenced, and analyzed for differentially expressed genes and pathways. Single cell RNA-seq (scRNA-seq) datasets from eosinophilic and non-eosinophilic CRSwNP and bulk RNA-seq of EpCs from mild/moderate and severe asthma were assessed. Immunofluorescent staining and ex vivo functional analysis of sinus EpCs were used to validate our findings. Results: Analysis within and across purified EpC subsets revealed an enrichment in glycolytic programming in CRSwNP vs CRSsNP. Correlation analysis identified mammalian target of rapamycin complex 1 (mTORC1) as a potential regulator of the glycolytic program and identified EpC expression of cytokines and wound healing genes as potential sequelae. mTORC1 activity was upregulated in CRSwNP, and ex vivo inhibition demonstrated that mTOR is critical for EpC generation of CXCL8, IL-33, and CXCL2. Across patient samples, the degree of glycolytic activity was associated with T2 inflammation in CRSwNP, and with both T2 and non-T2 inflammation in severe asthma. Conclusions: Together, these findings highlight a metabolic axis required to support epithelial generation of cytokines critical to both chronic T2 and non-T2 inflammation in CRSwNP and asthma.

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Section: Epithelial Glycolysis Can Be Induced By T2 and T17 Cytokines...mentioning

confidence: 99%

Increased epithelial mTORC1 activity in chronic rhinosinusitis with nasal polyps

Huang,

Hallen,

Lee

et al. 2023

Preprint

View full text Add to dashboard Cite

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Targeting reprogrammed metabolism as a therapeutic approach for respiratory diseases

Gan,

Zhang,

Fred Wong

2024

Biochemical Pharmacology

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The Effects of Viral Infection on Lymphocyte Metabolism: A New Perspective on Disease Characterization

Dymond¹

2018

Viral Immunology

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Over the past decade, metabolic dysfunction has been re-examined as an area of interest in a variety of atopic, malignant, and autoimmune conditions. The unique immune and, specifically, lymphocyte metabolic dysfunctions in disease are starting to be more clearly classified. Exploring the lymphocyte metabolic profiles of these diseases in the current literature, we characterize these diseases into two distinct metabolic groups. The influence of viral infection on immune metabolic dysfunction is explored. During an acute or chronic infection, there is a varied rapid shift in nutrients available to immune cells. This article explores the effect of these changes in nutrient availability and the resulting outcome on immune cell function. From this, a new hypothesis is proposed that these two groups of conditions, characterized by two unique immune profiles, are caused by either acute or chronic viral infections. The physiology behind this is explored, which proposes a new step between a healthy immune system and that of disease, in a unique working model.

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Switching of Glucose Metabolism from Oxidative Phosphorylation to Aerobic Glycolysis (the Warburg Effect) in T-Cells from Patients with Asthma

Cited by 5 publications

References 0 publications

Increased epithelial mTORC1 activity in chronic rhinosinusitis with nasal polyps

Increased epithelial mTORC1 activity in chronic rhinosinusitis with nasal polyps

Targeting reprogrammed metabolism as a therapeutic approach for respiratory diseases

The Effects of Viral Infection on Lymphocyte Metabolism: A New Perspective on Disease Characterization

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