Switching to Intravenous Methadone in Advanced Cancer Patients: A Retrospective Analysis

Mercadante, Sebastiano; Cascio, Alessio Lo; Casuccio, Alessandra

doi:10.1016/j.jpainsymman.2023.04.026

Cited by 3 publications

(1 citation statement)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…More recently, intravenous methadone dose titration was used for opioid switching in patients poorly responsive to different types of opioids. Unlike reports of morphine treatment [26], the effective dose was multiplied by three to establish the intravenous daily dose to be given as a continuous infusion. Doses were then changed according to the clinical needs.…”

Section: Subcutaneous and Intravenous Opioidsmentioning

confidence: 99%

The Use of Parenteral Opioids in Cancer Pain Management

Mercadante

2023

Cancers

Self Cite

View full text Add to dashboard Cite

Opioids should be offered to patients with moderate-to-severe pain related to cancer or active cancer treatment unless contraindicated. Although oral administration of opioids is generally preferable, a parenteral route may be advisable and mandatory in some clinical circumstances. Parenteral administration of opioids may accelerate the achievement of analgesia. The intravenous route fits the need of rapid achievement of analgesia in patients poorly responsive to other opioids and provides a fast analgesia in patients with breakthrough pain, that has a specific temporal pattern requiring a rapid analgesic effect. When the oral route is unavailable for the presence of nausea, vomiting, or dysphagia. the parenteral route is one of the principal options. Opioids have different pharmacokinetic and pharmacodynamic characteristics and should be chosen according to the individual needs. Thus, the knowledge and experience with these routes of administration are mandatory for anesthesiologists committed to cancer pain management.

show abstract

Section: Subcutaneous and Intravenous Opioidsmentioning

confidence: 99%