Swyer-James-MacLeod syndrome: an important differential diagnosis in adulthood

Fontes, Carla Pereira; Sousa, Marta

doi:10.1136/bcr-2021-246337

Cited by 5 publications

(15 citation statements)

References 4 publications

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“…SJMS is an acquired disease secondary to infectious bronchiolitis and pneumonitis in childhood. 1,3 Patients may remain asymptomatic into adulthood and/or have been misdiagnosed with asthma similar to our patient. The incidence of SJMS in pregnancy is estimated at 1:2500.…”

Section: Discussionmentioning

confidence: 66%

Swyer-James-MacLeod syndrome in pregnancy: A case report

et al. 2022

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Scant literature is available regarding pregnancy outcomes in women with Swyer-James-MacLeod syndrome, a rare obstructive lung disease. We present a case of a woman with this syndrome in pregnancy. Her baseline pulmonary function tests (PFT) demonstrated moderate airflow obstruction however she had excellent functional status and exercise tolerance. Her disease remained clinically stable in pregnancy. PFTs demonstrated slight worsening of her obstruction with forced expiratory volume in one second (FEV1). 59% and FEV1/FVC ratio 64%. She was diagnosed with gestational diabetes requiring metformin and insulin. Her labor and delivery was uncomplicated with vaginal delivery of a live male at term with no maternal respiratory complications. She did have a delayed postpartum hemorrhage requiring a D&C procedure. This case report demonstrates women with Swyer-James-MacLeod syndrome can have a successful pregnancy and need not avoid pregnancy if desired.

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Section: Discussionmentioning

confidence: 66%

Swyer-James-MacLeod syndrome in pregnancy: A case report

et al. 2022

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“…Every reviewed article [1][2][3][4][5][6][7][8][9][10] noted that radiological findings are the gold standard for diagnosis of SJS. On chest radiography, the major finding is unilateral hyperlucency but Moore et al [8] revealed that bilateral hyperlucency was noted in one of his eight cases and Bandeira et al [4] observed patchy lucency in the contralateral lung.…”

Section: Discussionmentioning

confidence: 99%

“…Hyperlucency can be poorly marginated or well demarcated as sharp-wedge-shaped [8]. Reduced bronchovascular markings, hilar markings, and volume loss of the lung are also noted [1][2][3][4][5][6][7][8]. Volume loss also led to a mediastinal shift toward the same side [4].…”

Section: Discussionmentioning

confidence: 99%

“…Volume loss also led to a mediastinal shift toward the same side [4]. Computed tomography of the lung in both inspiratory and expiratory phases showed diffuse hypoattenuation of lung fields predominantly unilateral but bilateral in few cases [1][2][3][4][5][6][7][8].…”

Section: Discussionmentioning

confidence: 99%

“…Although the occurrence is said to be in childhood [ 4 , 6 ]. Fontes et al reported that it must be an important differential diagnosis in adulthood because it is rarely diagnosed in children or adolescents [ 7 ]. Like the patients in this study, during the literature search we found that the majority of the cases were diagnosed in adulthood [ 1 , 3 , 5 - 7 ].…”

Section: Discussionmentioning

confidence: 99%

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Swyer-James Syndrome: A Rare Radiological Report of Two Cases Presenting in Adulthood

Kumar,

Joseph,

Sathiamoorthy

et al. 2024

Cureus

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Swyer-James syndrome (SJS), also termed MacLeod syndrome, is an acquired secondary unilateral hyperlucency of the lung due to childhood lung infections. This disorder can be diagnosed in children; however if there are few or no symptoms, diagnosis can be missed and can then be detected later in adult life as an incidental finding. We present here the case reports of two patients, where one of them had a unique presentation of unilateral hyperlucency on a chest radiograph and a bilateral mosaic pattern on CT lung but with no history of childhood infections and another case with unilateral hyperlucency of the lung with the history of childhood infection were diagnosed as SJS. This article is important as it highlights the significant radiological finding in accurately diagnosing this condition, when the presenting complaint and past history are inconclusive, thereby guiding proper management.

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Swyer-James-Macleod Syndrome in a Geriatric Patient: a Case Report

Panchal,

Shah,

Bhowmik

et al. 2023

SN Compr. Clin. Med.

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Hyper-lucent lung syndrome or Swyer-James-Macleod syndrome is a rare, often an incidental nding, primarily showing unilateral hyper-lucency as a consequence of bronchiolitis obliterans. Often diagnosed in early childhood; though in some cases it may only be discovered in adulthood or on account of recurrent chest infections. Case Presentation:A patient presented to our outpatient center with complaints of shortness of breath with mild to moderate exertional dyspnea & exacerbations of symptoms classically associated with chronic obstructive pulmonary disease. Complaints have persisted for several years with waxing & waning intensity. There is a history of migraine, atrial brillation, hypothyroidism, and colon & breast cancer without recurrence.Computed tomography of the chest with intravenous contrast showed asymmetric emphysematous changes with marked hyperin ation & attenuated vasculatures con ned to the middle lobe of the right lung.The patient was started on a combination of inhaled long-acting beta-agonists, corticosteroids & longacting muscarinic antagonists and is almost asymptomatic. Conclusion:Geriatric patients are at increased risk of various age-related diseases, respiratory disorders being among them. Knowledge of this rare condition allows for its appropriate management as it often coexists with bronchiectasis & results in frequent respiratory infections, which may be preventable.

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Swyer-James-MacLeod syndrome: an important differential diagnosis in adulthood

Cited by 5 publications

References 4 publications

Swyer-James-MacLeod syndrome in pregnancy: A case report

Swyer-James-MacLeod syndrome in pregnancy: A case report

Swyer-James Syndrome: A Rare Radiological Report of Two Cases Presenting in Adulthood

Swyer-James-Macleod Syndrome in a Geriatric Patient: a Case Report

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