Sydney Ringer (1834–1910) and Alexis Hartmann (1898–1964)

Lee, J. Alfred

doi:10.1111/j.1365-2044.1981.tb08698.x

Cited by 57 publications

(28 citation statements)

References 27 publications

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“…Sydney Ringer was born in 1834 and when in his midtwenties trained at University College Hospital in London, becoming a full physician in 1866 [1]. He had both a busy and a varied medical career, in addition to developing as one of the earliest clinical research pharmacologists.…”

Section: Discussionmentioning

confidence: 99%

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Is Hartmann's the solution?

White

Goldhill

1997

Anaesthesia

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SummaryAs Hartmann's solution is commonly used by anaesthetists, we surveyed a group of Part III FRCA candidates to establish their knowledge of its constituents and the purpose and metabolism of the lactate in solution. Of the 82 candidates surveyed only three (4%) accurately recorded the electrolytes and their concentrations in Hartmann's solution. Lactate was stated to be a source of bicarbonate by 52 (63%) and a source of glucose by 17 (21%). The descriptions of lactate metabolism were largely imprecise, none was complete and 24 (29%) of candidates offered no explanation. The constituents of Hartmann's solution and their concentrations are designed to match those of plasma, reducing ion and fluid shifts postinfusion. The lactate in Hartmann's solution is metabolised by both oxidation and gluconeogenesis, predominantly in the liver, and bicarbonate is generated by both processes over 1-2 h. Hartmann's solution is often regarded as the anaestheticpanacea of fluid resuscitation. This crystalloid formulation is routinely employed as the rehydration and maintenance solution of choice in the operating theatre. In discussion with colleagues it became apparent that knowledge regarding the concentration of the constituent ions and the metabolism of the lactate content varied widely. We therefore decided to assess the level of knowledge about Hartmann's solution amongst the wider anaesthetic community. MethodsWe obtained permission from The Royal College of Anaesthetists to survey candidates attending the Part III FRCA College course in February 1996. At the end of an afternoon lecture session, those present were asked to complete a voluntary and confidential questionnaire. The candidates were given no time limit for completing the task, but were instructed not to confer with each other, nor to refer to texts. The questionnaire (see Appendix 1) asked for the following information: 1 the constituents and their concentrations in 1 litre of 0.9% sodium chloride; 2 the constituents and their concentrations in 1 litre of Hartmann's solution; 3 the purpose of the lactate in Hartmann's solution; 4 the metabolism of the lactate in Hartmann's solution.In addition to the survey, we also reviewed the anaesthetic textbooks present in the anaesthetic library of The Royal London Hospital to establish the availability of 'source information' under the following headings: 1 Hartmann's solution -constituents, metabolism; 2 Ringer's lactate solution -constituents, metabolism; 3 lactate metabolism.

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Section: Discussionmentioning

confidence: 99%

“…As a clinician his interest was in paediatrics. Like Ringer before him, he too pursued a scientific research career [1]. His research work centred around treating acidosis in sick children.…”

Section: Discussionmentioning

confidence: 99%

Is Hartmann's the solution?

White

Goldhill

1997

Anaesthesia

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“…[7] Moreover, fluid resuscitation was advanced later by Alexis Hartmann, who modified a physiologic salt solution developed in 1885 by Sidney Ringer to rehydrate children with gastroenteritis (LEE 1115(LEE -1121 . [9] After that, in 1941 they developed blood fractionation then human albumin was used for the first time in large quantities for resuscitation of patients who were burned during the attack on Pearl Harbor in the same year (LEE 1115-1121). [9] Nowadays, fluids resuscitation is used in almost in patients with severe trauma and burns, patients undergoing general anesthesia for major surgery and in patients in the ICU.…”

Section: Introductionmentioning

confidence: 99%

“…[9] After that, in 1941 they developed blood fractionation then human albumin was used for the first time in large quantities for resuscitation of patients who were burned during the attack on Pearl Harbor in the same year (LEE 1115-1121). [9] Nowadays, fluids resuscitation is used in almost in patients with severe trauma and burns, patients undergoing general anesthesia for major surgery and in patients in the ICU. It is one of the most abundant interventions in acute medicine.…”

Section: Introductionmentioning

confidence: 99%

Preference of Physician for Management of Patients with Trauma, (Crystalloids versus Colloids)

2017

IJSR

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Abstract:Objectives: This is cross-sectional study was conducted in Abha and KhamisMushayt Hospitals, KSA, Aseer Region to assess and evaluate the use of fluids resuscitation among trauma patients. The aim of this experiment was to compare and contrast the use of colloids and crystalloids in fluid management for trauma among health practitioner. Methods: A number of 158 doctors were included in this study. The ranks of them ranged from house officer or internist up to senior consultants in most medical specialties. A selfadministered questionnaire has been developed and distributed as hard copy and a google designed with a link. It comprised a personal characteristic, questions about common fluids which has been used during trauma resuscitation, and also the preferred fluids. Moreover, questions about a written local or international protocols in the hospitals and any experiences of fluids overload or pulmonary edema which occurred before. Result: More than 90% choose to work with crystalloids whereas the other 10% preferred colloids. On the other hand, out of the 10% who preferred colloids 8% had only less than 1-year experience in their specialties. With regards to crystalloids, the majority of participants (more than 60%) preferred the use of normal saline, 33% ringer lactate, and only 4.4% used dextrose in saline. The most popular colloid during trauma fluids resuscitation was found to be the human albumin (more than 60%), while more than 25% demonstrated dextran. More than 70% of participants had patients who developed pulmonary edema during management. Regarding this, those who were treated with the combination of crystalloid and colloids showed the high percentage (more than 50%). However, when crystalloids and colloids were used separately, it was found to be 33% and 14% respectively. Conclusion: The study concludes that the most preferred fluids therapy in trauma patients or seriously ill patients was found to be crystalloids regardless the theoretically findings that shows the exact opposite. Meanwhile, the high percentage of trauma patients who developed pulmonary edema was found among those who were treated with both crystalloids and colloids therapy. However, this issue needs more studies in the future. Also, a clear written protocol will help and guide fluids therapy.

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“…and conduction of peripheral nerve impulses. [3][4][5] It was in 1882 when Ringer began his studies on organic constituents of blood to see their influence on the contraction of the heart. His ultimate goal was to create an artificial circulating fluid that would maintain a contracting heart.…”

Section: Chapter 2: Ringer's Solutionmentioning

confidence: 99%

Comparison of Regular Ringer’s Solution and Glucose Ringer’s Solution on the Longevity of the Hirudo medicinalis’ Retzius Cell

Peretti¹

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Sydney Ringer (1834–1910) and Alexis Hartmann (1898–1964)

Abstract: SummaryThis article outlines the careers and the achievements of Sydney Ringer(1834Ringer( -1910 and Alexis Hartmann (i898-1964), bolh of whom gave their names to well-known solutionsfor intravenous infusions.

Cited by 57 publications

References 27 publications

Is Hartmann's the solution?

Is Hartmann's the solution?

Preference of Physician for Management of Patients with Trauma, (Crystalloids versus Colloids)

Comparison of Regular Ringer’s Solution and Glucose Ringer’s Solution on the Longevity of the Hirudo medicinalis’ Retzius Cell

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