This paper is concerned with two types of word-level asymmetries and their interaction: leftright asymmetries and stem-word asymmetries. Two left-right asymmetries are examined from a wide range of languages, one morphological (the predominance of suffixation over prefixation), one phonological (the preference for anticipatory over perseverative phonology). Since phonological processes are often triggered by features which originate in roots, a second asymmetry is also addressed: the tendency for suffixes to be more tightly bound to roots than prefixes. Asymmetries between stem-vs. word phonology are examined in Bantu, where suffixes are incorporated into a derived stem domain, from which prefixes are typically excluded. This root+suffix stem domain is shown to be the locus of phonological activity in Proto-Bantu and throughout the large Bantu family, which divides into two typological zones: (i) Northwest Bantu languages, which impose a maximal size condition and stringent consonant distribution constraints on stems; (ii) Central Bantu languages, which do not restrict the size or consonant distribution of stems, but frequently impose a minimal size condition on words. The study presents a number of generalizations concerning such asymmetries and identifies questions for future research.