Symbiogenesis: the hidden face of constantin Merezhkowsky

Sapp, Jan; Carrapiço, Francisco; Zolotonosov, Mikhail

doi:10.1080/03919710210001714493

Cited by 51 publications

(46 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Given the mutualistic relationship between DcPV and the wasp, we can draw tentative parallels with the symbiogenesis theory: that mitochondria and chloroplasts (and potentially other organelles) were once free-living prokaryotic organisms that became assimilated by eukaryotes (Sapp et al, 2002). Ultimately, this comparison between symbiont-mediated manipulation and the symbiogenesis theory suggests that over evolutionary time, a virus using a parasite as a vector may start to lose its pre-symbiosis traits until eventually it becomes an element only capable of behavioral manipulation and self-replication.…”

Section: Symbiogenesis: a Potential Evolutionary Outcome Of Symbiont-mentioning

confidence: 99%

Lessons in Mind Control: Trends in Research on the Molecular Mechanisms behind Parasite-Host Behavioral Manipulation

Herbison

2017

Front. Ecol. Evol.

View full text Add to dashboard Cite

Scientific and public interest in host manipulation by parasites has surged over the past few decades, resulting in an exponential growth of cases where potential behavioral manipulation has been identified. However, these studies dwarf the number of genuine attempts to elucidate the mechanistic processes behind this behavioral manipulation. Ultimately, this imbalance has slowed progress in the study of the mechanisms underlying host manipulation. As it stands, research suggests that the mechanisms of host manipulation fall into three categories: immunological, genomic/proteomic and neuropharmacological, and forth potential category: symbioant-mediated manipulation. After exploration of the literature pertaining to these four pathways, four major trends become evident. First and foremost, there is a severe disconnect between the observed molecular and behavioral shifts in a parasitized host. Indeed, very rarely a study demonstrates that molecular changes observed in a host are the result of active manipulation by the resident parasite, or that these molecular changes directly result in behavioral manipulation that increases the parasite's fitness. Secondly, parasites may often employ multiple pathways in unison to achieve control over their hosts. Despite this, current scientific approaches usually focus on each manipulation pathway in isolation rather than integrating them. Thirdly, the relative amount of host-parasite systems yet to be investigated in terms of molecular manipulation is staggering. Finally, as a result of the aforementioned trends, guiding mechanisms or principles for the multiple types of behavioral manipulation are yet to be found. Researchers should look to identify the manipulative factors required to generate the molecular changes seen in hosts, while also considering the "multi-pronged" approach parasites are taking to manipulate behavior. Assessing gene expression and its products during transitional periods in parasites may be a key methodological approach for tackling these recent trends in the host manipulation literature.

show abstract

Section: Symbiogenesis: a Potential Evolutionary Outcome Of Symbiont-mentioning

confidence: 99%

Lessons in Mind Control: Trends in Research on the Molecular Mechanisms behind Parasite-Host Behavioral Manipulation

Herbison

2017

Front. Ecol. Evol.

View full text Add to dashboard Cite

show abstract

“…Margulis further argues that the first nucleated cells also originated as the result of the merging of different prokaryotes. In fact, the field of symbiogenesis today is a fast rising one, with implementations reaching as far as botany, insectology, virology and zoology (Sapp 2003). It now becomes abundantly clear that every organism alive today is the result of symbiogenetic mergers; it undergoes lateral gene transfer through contact with parasites, or through bacterial or viral infections; and it lives, to a great or lesser extent, in symbiosis with other creatures.…”

Section: Evolution By Means Of Natural Selection a Meta-theoretical mentioning

confidence: 99%

“…Symbiogenesis was first recognized to be an evolutionary mechanism by Merezhkowsky (Sapp et al 2002). Unfortunately, this mechanism has long been neglected by the mainstream biological community, partly due to the success of selectionist approaches.…”

Section: The Complexification Of Evolutionmentioning

confidence: 99%

Darwin’s legacy

Gontier

2010

Theory Biosci.

View full text Add to dashboard Cite

“…Such views were common particularly in Russia [24]. For example, Mereschkowsky [25] makes no mention of conflict (but see [26]). Later, Wallin [27] Later theorists of course did raise the issue of conflictboth in general, and with regard to mitochondria, in particular.…”

Section: Conflict and Conflict Mediation And The Endosymbiont Theorymentioning

confidence: 99%

Why did eukaryotes evolve only once? Genetic and energetic aspects of conflict and conflict mediation

Blackstone

2013

Phil. Trans. R. Soc. B

View full text Add to dashboard Cite

According to multi-level theory, evolutionary transitions require mediating conflicts between lower-level units in favour of the higher-level unit. By this view, the origin of eukaryotes and the origin of multicellularity would seem largely equivalent. Yet, eukaryotes evolved only once in the history of life, whereas multicellular eukaryotes have evolved many times. Examining conflicts between evolutionary units and mechanisms that mediate these conflicts can illuminate these differences. Energy-converting endosymbionts that allow eukaryotes to transcend surface-to-volume constraints also can allocate energy into their own selfish replication. This principal conflict in the origin of eukaryotes can be mediated by genetic or energetic mechanisms. Genome transfer diminishes the heritable variation of the symbiont, but requires the de novo evolution of the protein-import apparatus and was opposed by selection for selfish symbionts. By contrast, metabolic signalling is a shared primitive feature of all cells. Redox state of the cytosol is an emergent feature that cannot be subverted by an individual symbiont. Hypothetical scenarios illustrate how metabolic regulation may have mediated the conflicts inherent at different stages in the origin of eukaryotes. Aspects of metabolic regulation may have subsequently been coopted from within-cell to between-cell pathways, allowing multicellularity to emerge repeatedly.

show abstract

Symbiogenesis: the hidden face of constantin Merezhkowsky

Cited by 51 publications

References 20 publications

Lessons in Mind Control: Trends in Research on the Molecular Mechanisms behind Parasite-Host Behavioral Manipulation

Lessons in Mind Control: Trends in Research on the Molecular Mechanisms behind Parasite-Host Behavioral Manipulation

Darwin’s legacy

Why did eukaryotes evolve only once? Genetic and energetic aspects of conflict and conflict mediation

Contact Info

Product

Resources

About