Symbiont dynamics of the Tibetan tick Haemaphysalis tibetensis (Acari: Ixodidae)

Wang, Rongrong; Li, Ningxin; Liu, Jiannan; Li, Tuo; Liu, Ming; Yu, Zhou; Liu, Jingze

doi:10.1186/s13071-017-2199-0

Cited by 10 publications

(3 citation statements)

References 42 publications

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“…Again, no bacteria were detected in salivary glands (Fig. 2C1) (13,14,25,27,28). To examine the presence and abundance of these species in lab-reared H. longicornis and R. haemaphysaloides, we quantified their relative abundance by real-time PCR using genus-specific primers (Fig.…”

Section: Resultsmentioning

confidence: 99%

Tissue Localization and Variation of Major Symbionts in Haemaphysalis longicornis, Rhipicephalus haemaphysaloides, and Dermacentor silvarum in China

Wang

Zhu

Dai

et al. 2018

Appl Environ Microbiol

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Ticks are important disease vectors, as they transmit a variety of human and animal pathogens worldwide. Symbionts that coevolved with ticks confer crucial benefits to their host in nutrition metabolism, fecundity, and vector competence. Although over 100 tick species have been identified in China, general information on tick symbiosis is limited. Here, we visualized the tissue distribution of sp. and sp. in lab-reared and by fluorescent hybridization. We found that sp. colonized exclusively the Malpighian tubules and ovaries of , while sp. additionally colonized the midgut of We also investigated the population structure of microbiota in ticks collected from Inner Mongolia, China, and found that ,, and are the three dominant genera. No significant difference in microbiota composition was found between male and female ticks. We again analyzed the tissue localization of sp. and sp. and found that they displayed tissue tropisms similar to those in , except that sp. colonized the nuclei of spermatids instead of ovaries in Altogether, our results suggest that sp. and sp. are the main symbionts in the three ticks and reside primarily in midgut, Malpighian tubules, and reproductive tissues, but their tissue distribution varies in association with species and sexes. Tick-borne diseases constitute a major public health burden, as they are increasing in frequency and severity worldwide. The presence of symbionts helps ticks to metabolize nutrients, promotes fecundity, and influences pathogen infections. Increasing numbers of tick-borne pathogens have been identified in China; however, knowledge of native ticks, especially tick symbiosis, is limited. In this study, we analyze the distribution of sp. and sp. in tissues of laboratory-reared and and field-collected We found that the localization patterns of sp. in three Chinese tick species were similar to those of other tick species. We also found a previously undefined intracellular localization of sp. in tick midgut and spermatids. In addition, we demonstrate that tissue tropisms of symbionts vary between species and sexes. Our findings provide new insights into the tissue localization of symbionts in native Chinese ticks and pave the way for further understanding of their functional capabilities and symbiotic interactions with ticks.

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Section: Resultsmentioning

confidence: 99%

Tissue Localization and Variation of Major Symbionts in Haemaphysalis longicornis, Rhipicephalus haemaphysaloides, and Dermacentor silvarum in China

Wang

Zhu

Dai

et al. 2018

Appl Environ Microbiol

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“…turanicus after CLE proliferation and colonization in ovaries ( Lalzar et al, 2014 ). Additional studies have shown that CLE are more abundant in ovaries and Malpighian tubules, but less abundant in other organs as salivary glands ( Noda et al, 1997 ; Lalzar et al, 2014 ; Wang et al, 2017 ; Buysse et al, 2019 ). As Rh.…”

Section: Impact Of Symbionts On Tick Physiologymentioning

confidence: 99%

The Symbiotic Continuum Within Ticks: Opportunities for Disease Control

et al. 2022

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Among blood-sucking arthropods, ticks are recognized as being of prime global importance because of their role as vectors of pathogens affecting human and animal health. Ticks carry a variety of pathogenic, commensal, and symbiotic microorganisms. For the latter, studies are available concerning the detection of endosymbionts, but their role in the physiology and ecology of ticks remains largely unexplored. This review paper focuses on tick endosymbionts of the genera Coxiella, Rickettsia, Francisella, Midichloria, and Wolbachia, and their impact on ticks and tick-pathogen interactions that drive disease risk. Tick endosymbionts can affect tick physiology by influencing nutritional adaptation, fitness, and immunity. Further, symbionts may influence disease ecology, as they interact with tick-borne pathogens and can facilitate or compete with pathogen development within the vector tissues. Rickettsial symbionts are frequently found in ticks of the genera of Ixodes, Amblyomma, and Dermacentor with relatively lower occurrence in Rhipicephalus, Haemaphysalis, and Hyalomma ticks, while Coxiella-like endosymbionts (CLEs) were reported infecting almost all tick species tested. Francisella-like endosymbionts (FLEs) have been identified in tick genera such as Dermacentor, Amblyomma, Ornithodoros, Ixodes, and Hyalomma, whereas Wolbachia sp. has been detected in Ixodes, Amblyomma, Hyalomma, and Rhipicephalus tick genera. Notably, CLEs and FLEs are obligate endosymbionts essential for tick survival and development through the life cycle. American dog ticks showed greater motility when infected with Rickettsia, indirectly influencing infection risk, providing evidence of a relationship between tick endosymbionts and tick-vectored pathogens. The widespread occurrence of endosymbionts across the tick phylogeny and evidence of their functional roles in ticks and interference with tick-borne pathogens suggests a significant contribution to tick evolution and/or vector competence. We currently understand relatively little on how these endosymbionts influence tick parasitism, vector capacity, pathogen transmission and colonization, and ultimately on how they influence tick-borne disease dynamics. Filling this knowledge gap represents a major challenge for future research.

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“…They are notorious vectors that can transmit various pathogens (viruses, rickettsiae, bacteria, spirochaetes and protozoans) among arthropods [ 1 , 2 ]. With climate change, new tick-borne pathogens and tick-borne diseases have become severe threats to public health all over the world [ 3 , 4 ]. With a high reproductive potential, the fully engorged female can lay up to several thousand eggs [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

The mRNA expression and enzymatic activity of three enzymes during embryonic development of the hard tick Haemaphysalis longicornis

Zhang

Qiu

et al. 2019

Parasites Vectors

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BackgroundThree main enzymes including cathepsin B, cathepsin D and acid phosphatase are involved in vitellin degradation, which is a major biochemical event of the embryonic development and can provide nutrients and metabolites for tick embryos. In the present study, the mRNA expression profiles and enzymatic activity of cathepsin B, cathepsin D and acid phosphatase were investigated during embryonic development in the tick Haemaphysalis longicornis.ResultsThe results revealed that all three enzymes were expressed throughout embryonic development. Both cathepsin B and acid phosphatase transcripts were accumulated during the first four days. Cathepsin B reached its highest expression on day 5, whereas the peak expression of acid phosphatase and cathepsin D occurred on day 11. The highest activity of cathepsin B was observed on the first day of egg development, whereas cathepsin D reached its highest activity on day 13. Acid phosphatase activity increased gradually during the first five days and then remained stable until the end of egg development.ConclusionsThree enzymes were expressed and activated in eggs, and also presented different dynamic changes with the development of embryos. The profiles of both mRNA expression and enzymatic activity of these enzymes indicate that they are controlled orderly and play multiple roles during embryonic development in ticks.

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Symbiont dynamics of the Tibetan tick Haemaphysalis tibetensis (Acari: Ixodidae)

Cited by 10 publications

References 42 publications

Tissue Localization and Variation of Major Symbionts in Haemaphysalis longicornis, Rhipicephalus haemaphysaloides, and Dermacentor silvarum in China

Tissue Localization and Variation of Major Symbionts in Haemaphysalis longicornis, Rhipicephalus haemaphysaloides, and Dermacentor silvarum in China

The Symbiotic Continuum Within Ticks: Opportunities for Disease Control

The mRNA expression and enzymatic activity of three enzymes during embryonic development of the hard tick Haemaphysalis longicornis

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