Symbiotic microbiome Staphylococcus aureus from human nasal mucus modulates IL-33-mediated type 2 immune responses in allergic nasal mucosa

Jeon, Yung Jin; Gil, Chan Hee; Won, Joong-Sun; Jo, Ara; Kim, Hyun Jik

doi:10.21203/rs.3.rs-24212/v3

Cited by 3 publications

(3 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the nasal microbiome of patients with AR, S. aureus colonization was significantly predominant, in concert with a high abundance of Staphylococcus spp. Our previous study showed that the distribution of S. aureus was significantly elevated in the nasal mucus of patients with AR, to the point that it constituted more than 20% of the identified nasal microbiome, and S. aureus colonization was most highly abundant relative to the composition of the normal mucus [25]. Thus, we sought to understand the contributions of Staphylococcus spp.…”

Section: Discussionmentioning

confidence: 99%

Compositional Alterations of the Nasal Microbiome and <i>Staphylococcus aureus</i>–Characterized Dysbiosis in the Nasal Mucosa of Patients With Allergic Rhinitis

Kim

Han

et al. 2022

Clin Exp Otorhinolaryngol

Self Cite

View full text Add to dashboard Cite

Objectives. Host–microbial commensalism can shape the innate immune responses in the nasal mucosa, and the microbial characteristics of the nasal mucus directly impact the mechanisms of initial allergic responses in the nasal epithelium. We sought to determine alterations of the microbial composition in the nasal mucus of patients with allergic rhinitis (AR) and to elucidate the interplay between dysbiosis of the nasal microbiome and allergic inflammation.Methods. A total of 364,923 high-quality bacterial 16S ribosomal RNA–encoding gene sequence reads from 104 samples from the middle turbinate mucosa of healthy participants and patients with AR was obtained and analyzed using the Quantitative Insights into Microbial Ecology pipeline.Results. We analyzed the microbiota in samples of nasal mucus from patients with AR (n = 42) and clinically healthy participants (n = 30). Proteobacteria (Ralstonia genus) and Actinobacteria (Propionibacterium genus) phyla were predominant in the nasal mucus of healthy subjects, whereas the Firmicutes (Staphylococcus genus) phylum was significantly abundant in the nasal mucus of patients with AR. Especially, Ralstonia genus were significantly dominant in the clinically healthy subjects. Additional pyrosequencing data from 32 subjects (healthy participants: N=15, AR patients: N=17) revealed a greater abundance of Staphylococcus epidermidis, Corynebacterium accolens, and Nocardia coeliaca, accounting for 41.55% of mapped sequences in the nasal mucus of healthy participants. The dysbiosis of nasal microbiome was more pronounced and Staphylococcus aureus exhibited the greatest abundance (37.69%) in the presence of microbial distribution in the nasal mucus of patients with AR depending on the positive response to house dust mites and patient age and height. Conclusions. This study revealed alterations in the nasal microbiome that occur in the nasal mucus of patients with AR at the levels of microbial genera and species. S. aureus–dominant dysbiosis was distinctive in the nasal mucus of patients with AR, suggesting a role of host–microbial commensalism in allergic inflammation.

show abstract

Section: Discussionmentioning

confidence: 99%

Compositional Alterations of the Nasal Microbiome and <i>Staphylococcus aureus</i>–Characterized Dysbiosis in the Nasal Mucosa of Patients With Allergic Rhinitis

Kim

Han

et al. 2022

Clin Exp Otorhinolaryngol

Self Cite

View full text Add to dashboard Cite

show abstract

“…Furthermore, the human microbiomes contribute to mucosal and immune system development, as well as to protection from external pathogens. [4][5][6] However, the system consists of trillions of microbiomes.…”

Section: Introductionmentioning

confidence: 99%

Human microbiomes in cancer development and therapy

Xia

Liu

et al. 2023

MedComm

View full text Add to dashboard Cite

Colonies formed by bacteria, archaea, fungi, and viral groups and their genomes, metabolites, and expressed proteins constitute complex human microbiomes. An increasing evidences showed that carcinogenesis and disease progression were link to microbiomes. Different organ sources, their microbial species, and their metabolites are different; the mechanisms of carcinogenic or procancerous are also different. Here, we summarize how microbiomes contribute to carcinogenesis and disease progression in cancers of the skin, mouth, esophagus, lung, gastrointestinal, genital, blood, and lymph malignancy. We also insight into the molecular mechanisms of triggering, promoting, or inhibiting carcinogenesis and disease progress induced by microbiomes or/and their secretions of bioactive metabolites. And then, the strategies of application of microorganisms in cancer treatment were discussed in detail. However, the mechanisms by which human microbiomes function are still poorly understood. The bidirectional interactions between microbiotas and endocrine systems need to be clarified. Probiotics and prebiotics are believed to benefit human health via a variety of mechanisms, in particular, in tumor inhibition. It is largely unknown how microbial agents cause cancer or how cancer progresses. We expect this review may open new perspectives on possible therapeutic approaches of patients with cancer.

show abstract

“…It is thought that Staphylococcus aureus-derived proteases may induce allergic airway inflammation (23). However, some experimental studies revealed that nasal commensal Staphylococcus aureus from subjects with AR mediated anti-allergic effects (24).…”

Section: Introductionmentioning

confidence: 99%

Local and systemic immune markers of persistent airway inflammation induced by house dust mite allergens

Tamašauskienė¹

2023

PIA

View full text Add to dashboard Cite

Laura Tamašauskienė successfully defended a doctoral dissertation “Local and Systemic Immune Markers of Persistent Airway Inflammation Induced by House Dust Mite Allergens” at the open session of the Medical Research Council of the Lithuanian University of Health Sciences on August 30, 2022. The Dissertation has been prepared at the Department of Immunology and Allergology of Faculty of Medicine of Lituanian University of Health Sciences during the period of the 2018–2022 year. The article presents the main results of the dissertation. Scientific Supervisor: Prof. Dr. Brigita Šitkauskienė (Lithuanian University of Health Sciences, Medical and Health Sciences, Medicine – M 001). The Defense Council: prof. Dr. Elona Juozaitytė, chairperson (Lithuanian University of Health Sciences, Medical and Health Sciences, Medicine – M 001); prof. Dr. Juozas Kupčinskas (Lithuanian University of Health Sciences, Medical and Health Sciences, Medicine – M 001); prof. Dr. Andrius Macas (Lithuanian University of Health Sciences, Medical and Health Sciences, Medicine – M 001); assoc. Prof. Dr. Vincas Urbonas (Vilnius University, Medical and Health Sciences, Medicine – M 001); dr. Nicholas Brodszki (Lund University, Medical and Health Sciences, Medicine – M 001).

show abstract

Symbiotic microbiome Staphylococcus aureus from human nasal mucus modulates IL-33-mediated type 2 immune responses in allergic nasal mucosa

Cited by 3 publications

References 15 publications

Compositional Alterations of the Nasal Microbiome and <i>Staphylococcus aureus</i>–Characterized Dysbiosis in the Nasal Mucosa of Patients With Allergic Rhinitis

Compositional Alterations of the Nasal Microbiome and <i>Staphylococcus aureus</i>–Characterized Dysbiosis in the Nasal Mucosa of Patients With Allergic Rhinitis

Human microbiomes in cancer development and therapy

Local and systemic immune markers of persistent airway inflammation induced by house dust mite allergens

Contact Info

Product

Resources

About