The 5G and beyond networks will intrinsically accommodate a wide range of use-case scenarios and expand the limit of legacy mobile systems. The 5G network architecture can handle the seamless operation of various wireless channels in a heterogeneous environment. The η-µ fading model is well-suited for versatile channels as it adapts to different fading behaviors in a broad-range propagation for non-line-of-sight (NLOS) circumstances. This paper evaluates the performance of heterogeneous wireless networks using η-µ fading channel under mobility conditions. We incorporated the random waypoint (RWP) model with η-µ distribution to model the dynamic behavior of non-homogeneous fading. The derivation of expressions for the probability density function (PDF) and cumulative distribution function (CDF) of the received signal power for a mobile network in all three-dimensional topologies is extracted. Consequently, the outage probability (OP) and average bit error rate (ABER) are analyzed to quantify the performance of the mobile system. The effect of co-channel interference (CCI) is investigated based on a desired and interfering signal transmitted in mobile networks. The proposed novel-form can characterize the performance of a mobile user, and the derivation is useful for measuring the effect of noise and interference on the signal. Finally, the novel-form applicability analyzes the impact of mobility incorporated in different fading channels such as Nakagami-m, Nakagami-q (Hoyt), Rayleigh, and one-sided Gaussian distributions.INDEX TERMS Co-channel interference, η-µ distribution, generalized fading model, heterogeneous network, random waypoint mobility.