Let I = I(D) be the edge ideal of a weighted oriented graph D, let G be the underlying graph of D, and let I (n) be the n-th symbolic power of I defined using the associated minimal primes of I. We prove that I 2 = I (2) if and only if every vertex of D with weight greater than 1 is a sink and G has no triangles. As a consequence, using a result of Mandal and Pradhan and the classification of normally torsion-free edge ideals of graphs, it follows that I (n) = I n for all n ≥ 1 if and only if every vertex of D with weight greater than 1 is a sink and G is bipartite. If I has no embedded primes, these two properties classify when I is normally torsion-free.