SymMap database and TMNP algorithm reveal Huanggui Tongqiao granules for Allergic rhinitis through IFN-mediated neuroimmuno-modulation

Kong, Ya-Ru; Hao, Mengyao; Chen, Aiping; Yi, Tianxing; Ke, Yang; Wang, Yi; Li, Pengfei; Jia, Xinbei; Han, Qin; Qi, Yuwei; Ji, Jie; Jin, Jing; Qian, Hua; Tai, Jun

doi:10.1016/j.phrs.2022.106483

Cited by 10 publications

(3 citation statements)

References 65 publications

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“…These pathways were also of vital importance in the targets network (Figure 2C, D). Besides, biological processes associated with IFN- were reported closely to allergic diseases represented by AR [31][32][33] , as well as those related to cell adhesion [34][35][36] and T cell [37][38][39] , which aligned with their significant positions within the multi-layered biological networks (Figure 2E, F).…”

Section: Network Target Analysis Of Tzd Against Armentioning

confidence: 86%

Clinical multi-omics reveals the role of Tuomin Zhiti Decoction Intervention in Allergic Rhinitis from the perspective of biological network

Zhao,

Wang,

Kong

et al. 2024

Preprint

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Background: Increasing evidence showed that seasonal allergic rhinitis (SAR), as an allergy disease, could be alleviated with traditional Chinese medicine (TCM) formula, one example being Tuomin Zhiti Decoction (TZD). However, as a complex composition of TCM herbs, the mechanism of TZD in the treatment of SAR remain unclear. Purpose: Uncover the mechanism of TZD for treating SAR based on computational analysis and clinical multi-omics experiments. Study design: Integrate computational analysis including network target analysis and machine learning algorithms with clinical multi-omics experiments and public omics data. Methods: By analyzing TZD's composition through a network-based method, we identified the biological effects of each compound, constructing a comprehensive biological network to elucidate TZD's molecular and pathway mechanisms against AR. Single-arm clinical trials on the gut microbiome and serum transcriptomics corroborated our computational insights. Further validation through public omics data highlighted key TZD compounds, paving the way for future research. Results: TZD was discovered to exert a regulatory effect on various modules associated with AR, as demonstrated by the constructed biological network. Insights from gut microbiome and serum transcriptomics in clinical trials, where immune-related microbiomes represented by Prevotella, as well as pathways and biological processes including antigen processing and presentation, activation and regulating immune cell surface receptor, were markedly enriched (P value < 0.05), indicated that TZD played a pivotal role in modulating immune processes and the immune cells against AR. With the verification of multi-omics, it was determined that TZD potentially influences immune responses and downstream immune cells like CD4+ T cells, through both direct mechanisms involving antigen and indirect mechanisms mediated by gut microbiomes in the treatment of AR. Conclusion: Through combination of computational prediction and analysis together with clinical multi-omics, a network target based framework provided a new insight for uncovering the mechanism of TZD for treating AR.

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Section: Network Target Analysis Of Tzd Against Armentioning

confidence: 86%

Clinical multi-omics reveals the role of Tuomin Zhiti Decoction Intervention in Allergic Rhinitis from the perspective of biological network

Zhao,

Wang,

Kong

et al. 2024

Preprint

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“…Previous studies have shown that the nasal immune environment of AR is associated to biological processes such as immune cell activation, differentiation, receptor signal transduction mainly of Th1 and Th2 cells, mast cells, and inflammation mediated by the TNF signaling pathway. These key modules and molecules are common key target pathways and molecules for the treatment of AR [ 50 ], and also play an important role in other respiratory diseases [ 51 ]. Based on the network target model, the synergistic effects of different TCM herbs and Jun-Chen-Zuo-Shi roles of herbs in YQTQP on AR in the network target model was further revealed.…”

Section: Discussionmentioning

confidence: 99%

Uncovering the mechanisms of Yi Qi Tong Qiao Pill in the treatment of allergic rhinitis based on Network target analysis

Wang¹,

Zhang²,

Zhang³

et al. 2023

Chin Med

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Objective The purpose of this study is to reveal the mechanism of action of Yi Qi Tong Qiao Pill (YQTQP) in the treatment of allergic rhinitis (AR), as well as establish a paradigm for the researches on traditional Chinese medicine (TCM) from systematic perspective. Methods Based on the data collected from TCM-related and disease-related databases, target profiles of compounds in YQTQP were calculated through network-based algorithms and holistic targets of TQTQP was constructed. Network target analysis was performed to explore the potential mechanisms of YQTQP in the treatment of AR and the mechanisms were classified into different modules according to their biological functions. Besides, animal and clinical experiments were conducted to validate our findings inferred from Network target analysis. Results Network target analysis showed that YQTQP targeted 12 main pathways or biological processes related to AR, represented by those related to IL-4, IFN-γ, TNF-α and IL-13. These results could be classified into 3 biological modules, including regulation of immune and inflammation, epithelial barrier disorder and cell adhesion. Finally, a series of experiments composed of animal and clinical experiments, proved our findings and confirmed that YQTQP could improve related symptoms of AR, like permeability of nasal mucosa epithelium. Conclusion A combination of Network target analysis and the experimental validation indicated that YQTQP was effective in the treatment of AR and might provide a new insight on revealing the mechanism of TCM against diseases. Trial registration Name of the registry: Chinese Clinical Trial Registry: Trial registration number: ChiCTR-TRC-13,003,137: Date of registration: Registered 29 March 2013 - Retrospectively registered: URL of trial registry record: https://www.chictr.org.cn/showproj.html?proj=6422.

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“…Traditional Chinese medicine (TCM) is a new source of abundant and diverse smallmolecule drug candidates, given the highly diverse bioactivities of natural products [26]. Currently available clinical data suggest that several medicinal plants and herbs are most frequently used in TCM due to their hypnotic effects, such as Plumula nelumbinis, Ziziphus jujuba Mill.…”

Section: Introductionmentioning

confidence: 99%

Discovery of Small-Molecule Antagonists of Orexin 1/2 Receptors from Traditional Chinese Medicinal Plants with a Hypnotic Effect

Fang

Wang

et al. 2023

Pharmaceuticals

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Insomnia is an important public health problem. The currently available treatments for insomnia can cause some adverse effects. Orexin receptors 1 (OX1R) and 2 (OX2R) are burgeoning targets for insomnia treatment. It is an effective approach to screening OX1R and OX2R antagonists from traditional Chinese medicine, which contains abundant and diverse chemical components. This study established an in-home ligand library of small-molecule compounds from medicinal plants with a definite hypnotic effect, as described in the Chinese Pharmacopoeia. Molecular docking was applied to virtually screen potential orexin receptor antagonists using molecular operating environment software, and surface plasmon resonance (SPR) technology was used to detect the binding affinity between potential active compounds and orexin receptors. Finally, the results of virtual screening and SPR analysis were verified through in vitro assays. We successfully screened one potential lead compound (neferine) as an orexin receptor antagonist from the in-home ligand library, which contained more than 1000 compounds. The screened compound was validated as a potential agent for insomnia treatment through comprehensive biological assays. This research enabled the discovery of a potential small-molecule antagonist of orexin receptors for the treatment of insomnia, providing a novel screening approach for the detection of potential candidate compounds for corresponding targets.

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SymMap database and TMNP algorithm reveal Huanggui Tongqiao granules for Allergic rhinitis through IFN-mediated neuroimmuno-modulation

Cited by 10 publications

References 65 publications

Clinical multi-omics reveals the role of Tuomin Zhiti Decoction Intervention in Allergic Rhinitis from the perspective of biological network

Clinical multi-omics reveals the role of Tuomin Zhiti Decoction Intervention in Allergic Rhinitis from the perspective of biological network

Uncovering the mechanisms of Yi Qi Tong Qiao Pill in the treatment of allergic rhinitis based on Network target analysis

Discovery of Small-Molecule Antagonists of Orexin 1/2 Receptors from Traditional Chinese Medicinal Plants with a Hypnotic Effect

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