“…[12] With respect to SDMA, initial studies did not find an association with adverse outcomes, [7,13,14] but some more recent studies reported positive associations with all-cause mortality or CVD. [11,15,16] Overall, prior studies on ADMA/SDMA and CVD or all-cause mortality were derived from many different study populations (general population, [15,17,18] patients with CVD, [9,11,19,20] renal diseases, [7,13,[21][22][23][24] diabetes, [25,26] or critically ill patients from intensive care unit,[27-29] respectively), differed in their methodological approaches (e.g. using types of samples (plasma vs. serum) or methods to determine the biomarker levels (HPLC vs. tandem mass spectroscopy vs. ELISA), or considered different confounders in their analysis.…”