Symmetrical effect of pre-exposure between alcohol and morphine on conditioned taste aversion

Ton, J.M. Ng Cheong; Amit, Zalman

doi:10.1016/0024-3205(83)90255-2

Cited by 22 publications

(4 citation statements)

References 20 publications

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“…If one agrees that the CF effect is based on the stimulus similarities between substances, then an apparent contrast exists between the results of the drug discrimination and the CF-CTA studies with ethanol. For example, morphine, nicotine or the Ca 2+ channel blocker, nimodipine have all been reported to attenuate ethanol-induced CTA in the CF-CTA procedure, but not to substitute for ethanol in the drug discrimination test (Winter, 1975;Ng Cheong Ton and Amit, 1983;De Beun et al, 1996;Bienkowski et al, 1998). In addition, MK-801, while able to substitute for ethanol, enhanced rather than diminished the ethanolinduced CTA in the present study.…”

Section: Discussioncontrasting

confidence: 38%

Prior Exposure to Mk-801 Sensitizes Rats to Ethanol-Induced Conditioned Taste Aversion

Bieńkowski

Koroś

Piasecki

et al. 1998

Alcohol and Alcoholism

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Pretreatment with an uncompetitive NMDA receptor antagonist, dizocilpine [(+)MK-801; six daily injections of 0.1 or 0.2 mg/kg, i.p.] significantly enhanced subsequent 1.5 g/kg ethanol-induced conditioned taste aversion (CTA). In a control experiment, dizocilpine (0.05-.2 mg/kg) produced only a marginal CTA. Thus, pre-exposure to low, non-aversive doses of MK-801 may sensitize rats to the aversive stimulus effects of ethanol.

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Section: Discussioncontrasting

confidence: 38%

Prior Exposure to Mk-801 Sensitizes Rats to Ethanol-Induced Conditioned Taste Aversion

Bieńkowski

Koroś

Piasecki

et al. 1998

Alcohol and Alcoholism

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“…The pre-exposure effect is the attenuation of conditioned aversion to a drug (the unconditioned stimulus) after previous exposure to it. This effect has been demonstrated for pre-exposure to morphine, ethanol, and THC (Diaz-Granados and Graham, 2007; Stewart and Eikelboom, 1978; Switzman et al, 1981; Ton and Amit, 1983), and appears to be stronger when the pre-exposure occurs during adolescence (Diaz-Granados and Graham, 2007). Our rats, which had received their “pre-exposure” to cocaine during the first CTA task in adolescence, exhibited a pre-exposure effect which weakened the second aversion, resulting in a higher CTA score.…”

Section: Discussionmentioning

confidence: 78%

Individual differences in cocaine conditioned taste aversion are developmentally stable and independent of locomotor effects of cocaine

Drescher

Foscue

Kuhn

et al. 2011

Developmental Cognitive Neuroscience

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Drugs of abuse induce complex motivational states in their users which have been shown to vary developmentally. In addition to developmental variation, interindividual variation in the rewarding and aversive effects of drugs of abuse is an important consideration. A rat model was used to assess whether the conditioned rewarding/aversive effects of cocaine were maintained as individuals matured from adolescence into adulthood. We tested rats in the cocaine conditioned taste aversion task as adolescents and again in adulthood. We observed a wide range of approach/avoidance behaviors in this task, and also observed that the relative interindividual differences in approach/avoidance are remarkably stable across the two developmental stages. Furthermore, we observed that these interindividual differences are not attributable to individual differences in cocaine-induced locomotor effects or individual differences in blood or brain cocaine levels. Taken together, these findings indicate that sensitivity to cocaine’s motivational effects is stable across development and part of a unique neurological process.

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“…For example, in one of the initial assessments of the effects of drug pre-exposure in taste avoidance learning Berman and Cannon [ 85 ] reported that rats exposed to ethanol prior to taste avoidance conditioning displayed attenuated ethanol-induced avoidance relative to non-pre-exposed subjects. Subsequent to this demonstration, exposure to a wide array of drugs has been reported to weaken taste avoidance conditioning with itself [ 86 , 87 , 88 ] and with compounds with shared neurochemical activity or effects ([ 55 , 56 , 89 , 90 , 91 ]; for reviews, see [ 1 , 2 , 91 ]). Similarly, exposure to a drug prior to place preference conditioning can sensitize the drug’s rewarding effects.…”

Section: Methodsmentioning

confidence: 99%

Effects of Serial Polydrug Use on the Rewarding and Aversive Effects of the Novel Synthetic Cathinone Eutylone

Manke,

Nunn,

Sulima

et al. 2023

Brain Sciences

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Background: As individual synthetic cathinones become scheduled and regulated by the Drug Enforcement Administration (DEA), new ones regularly are produced and distributed. One such compound is eutylone, a novel third-generation synthetic cathinone whose affective properties (and abuse potential) are largely unknown. The following experiments begin to characterize these effects and how they may be impacted by drug history (a factor affecting reward/aversion for other drugs of abuse). Methods: Eutylone was assessed for its ability to induce conditioned taste avoidance (CTA; aversive effect) and conditioned place preference (CPP; rewarding effect) and their relationship (Experiment 1). Following this, the effects of exposure to cocaine or 3,4-methylenedioxymethamphetamine [MDMA] on eutylone’s affective properties were investigated (Experiment 2). Results: Eutylone produced dose-dependent CTA and CPP (Experiment 1), and these endpoints were unrelated. Pre-exposure to cocaine and MDMA differentially impacted taste avoidance induced by eutylone (MDMA > cocaine) and did not impact eutylone-induced place preference. Conclusions: These data indicate that eutylone, like other synthetic cathinones, has co-occurring, independent rewarding and aversive effects that may contribute to its abuse potential and that these effects are differentially impacted by drug history. Although these studies begin the characterization of eutylone, future studies should examine the impact of other factors on eutylone’s affective properties and its eventual reinforcing effects (i.e., intravenous self-administration [IVSA]) to predict its use and abuse liability.

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Symmetrical effect of pre-exposure between alcohol and morphine on conditioned taste aversion

Cited by 22 publications

References 20 publications

Prior Exposure to Mk-801 Sensitizes Rats to Ethanol-Induced Conditioned Taste Aversion

Prior Exposure to Mk-801 Sensitizes Rats to Ethanol-Induced Conditioned Taste Aversion

Individual differences in cocaine conditioned taste aversion are developmentally stable and independent of locomotor effects of cocaine

Effects of Serial Polydrug Use on the Rewarding and Aversive Effects of the Novel Synthetic Cathinone Eutylone

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