Symmetrical thalamic lesions in infants.

Eicke, Martin; Briner, J.; Willi, Ulrich; Uehlinger, J; Boltshauser, Eugen

doi:10.1136/adc.67.1_spec_no.15

Cited by 30 publications

(18 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…CT usually shows no other morphological abnormalities; occasionally, additional hypodense areas in the white matter are reported [Eicke et al, 19921. MRI in our patient showed additional retardation of myelination, consistent with autopsy findings in some of the previous cases [Wilson et al, 1982;Eicke et a]., 19921.…”

Section: Discussionsupporting

confidence: 91%

Discordant infantile encephalopathy with symmetrical thalamic calcifications in identical twins

Knaap

Barth

1994

Am. J. Med. Genet.

View full text Add to dashboard Cite

Connatal thalamic calcifications in apparently uneventful pregnancies have been described in various case reports and in a single report in two sibs. On the other hand, this lesion is known to occur after a hypoxic-ischemic accident in the immature brain. In the present report infantile encephalopathy with symmetrical thalamic calcifications is observed in one sib of a monozygous twin pair. This observation adds to the evidence that the condition is acquired, most probably on the basis of hypoxia-ischemia, and provides strong evidence against autosomal-recessive inheritance.

show abstract

Section: Discussionsupporting

confidence: 91%

Discordant infantile encephalopathy with symmetrical thalamic calcifications in identical twins

Knaap

Barth

1994

Am. J. Med. Genet.

View full text Add to dashboard Cite

show abstract

“…Leukomalacia and delayed myelination are known to indicate a poor outcome [40][41][42] as well as thalamic and/or basal ganglia lesions [43], since the striatum is now considered to contribute to the generation and maintenance of motor skills [44]. A more interesting point arising from our study is that isolated atrophy was the main MRI finding in the group of patients showing diffuse brain damage.…”

Section: Discussionsupporting

confidence: 50%

Predictive Significance of Magnetic Resonance Imaging at 4 Months of Adjusted Age in Infants after a Perinatal Neurologic Insult

Millet

Bartoli²,

Lacroze³

et al. 1998

Neonatology

View full text Add to dashboard Cite

The aim of this prospective study was to evaluate the predictive significance of magnetic resonance imaging (MRI) performed at 4 months of corrected age in 60 neonates after a perinatal neurologic insult. Follow-up ranged from 2 to 5 years of chronological age. MRI examination was normal in 10; isolated external hydrocephalus was found in 15 infants. Twenty-three of these infants developed normally. Focal or multifocal lesions were shown in 6 infants, of whom 2 developed normally. Diffuse brain involvement was present in 29 cases as atrophy (n = 18), leukomalacia (n = 5), basal ganglia lesions (n = 3), and delayed myelination (n = 3). All but 4 infants showed neurologic impairment. MRI performed at 4 months of adjusted age is of prognostic significance in neonates who suffer a moderate or mild neurologic insult.

show abstract

“…Generally, babies suffering from perinatal injury are initially flaccid, and they become irritable and hypertonic after 12 to 48 hrs (Brown et al 1974). There are few reports on a newborn with spasticity at birth (Eicke et al 1992), in which spasticity at birth implies the existence of antenatal brain insult. Therefore, the spasticity appearing at birth is evidence that the insult to the fetus must have occurred before delivery.…”

Section: Discussionmentioning

confidence: 99%

Neonatal-Onset Brainstem Reticular Reflex Myoclonus Following a Prenatal Brain Insult: Generalized Myoclonic Jerk and a Brainstem Lesion

Kakisaka

Haginoya

Togashi

et al. 2007

Tohoku J. Exp. Med.

View full text Add to dashboard Cite

Brainstem reticular reflex myoclonus (BRRM) is characterized by sudden, generalized, shock-like movements that can be elicited by sensory stimulation. We present a boy, born after 35 weeks gestation, who was diagnosed with neonatal-onset BRRM. Within 1 hr of birth, the patient showed spasticity and generalized clonic movements of all limbs elicited with tactile stimulation anywhere on the body. Surface electromyography showed co-contraction of agonistic and antagonistic muscles, revealing that his generalized clonic movements were tremulous myoclonus in nature. Brain magnetic resonance imaging (MRI) at 21 hrs after birth disclosed highintensity lesions in the Rolandic area, thalamus, basal ganglia, and brainstem, including the dorsal pons and medulla, the center of BRRM, in T1-weighted images. Follow-up MRI at 1 month revealed dramatic improvement in the pontine lesion. The patient showed gradual remission of the characteristic movements, which disappeared at 1 year of age, but the patient died unexpectedly at 1 year and 3 months. In conclusion, neonatal BRRM arises as a result of severe brainstem injury, and the associated lesions may only be seen temporarily on MRI taken soon after birth. prenatal brain insult; brainstem lesion; brainstem reticular reflex myoclonus; stimulus-sensitive generalized clonic movement

show abstract

Symmetrical thalamic lesions in infants.

Cited by 30 publications

References 15 publications

Discordant infantile encephalopathy with symmetrical thalamic calcifications in identical twins

Discordant infantile encephalopathy with symmetrical thalamic calcifications in identical twins

Predictive Significance of Magnetic Resonance Imaging at 4 Months of Adjusted Age in Infants after a Perinatal Neurologic Insult

Neonatal-Onset Brainstem Reticular Reflex Myoclonus Following a Prenatal Brain Insult: Generalized Myoclonic Jerk and a Brainstem Lesion

Contact Info

Product

Resources

About