Symmetrical treatment of “Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition”, for major depressive disorders

Sawamura, Jitsuki; Morishita, Shigeru; Ishigooka, Jun

doi:10.1186/s13029-015-0041-7

Cited by 9 publications

(7 citation statements)

References 18 publications

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“…In this study, we observed the effects of MS, CUMS, and MS combined CUMS on body weight and behaviors of rats. Knowing that losing weight could be one of the symptoms of depression ( 27 ), the treatment of CUMS and MS+CUMS led to an obvious loss in weight in our study, which indicated that animals were in a progression of depression-like behavior, and this was consistent with previous studies ( 28 , 29 ). Gracia-Rubio et al reported that maternal separation caused emotional alterations but had no impact on body weight ( 30 ).…”

Section: Discussionsupporting

confidence: 92%

The Effect of Early Maternal Separation Combined With Adolescent Chronic Unpredictable Mild Stress on Behavior and Synaptic Plasticity in Adult Female Rats

Huang

Shen

et al. 2021

Front. Psychiatry

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Our aims were to evaluate the depression model of early maternal separation (MS) combined with adolescent chronic unpredictable mild stress (CUMS) in female adult SD rats to observe the behavior and the expressions of synaptic proteins in rats and to provide a reference for the screening of antidepressant drug activity. In our study, MS and CUMS were conducted to establish a dual stress model on female rats. Behavioral tests, including the sucrose preference test, open field test, and zero maze test, were used to detect depression-like and anxiety-like behavior of animals. Nissl staining was used to detect the number of neuronal cells in the hippocampus CA1 and DG regions of rats from each group. Synaptophysin (SYN), postsynaptic density-95 (PSD-95), and growth-associated protein-43 (GAP-43) expressions in the hippocampus were detected by western blot. Expression of the hippocampus SYN protein was further detected by immunohistochemistry. Rats in the MS+CUMS group presented more serious depression-like and anxiety-like behavior than in the MS group. Also, few Nissl bodies in the hippocampus CA1 and DG regions, less percentage of SYN-positive cells, and downregulated expressions of SYN, PSD-95, and GAP43 were found in the hippocampus of rats in MS+CUMS group. In conclusion, adult female rats that underwent MS and CUMS performed more critical depression-like and anxiety-like behaviors, and this process may be resulted from synaptic plasticity impairment.

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Section: Discussionsupporting

confidence: 92%

The Effect of Early Maternal Separation Combined With Adolescent Chronic Unpredictable Mild Stress on Behavior and Synaptic Plasticity in Adult Female Rats

Huang

Shen

et al. 2021

Front. Psychiatry

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“…Weight loss is one of the nine specific symptoms of MDD (Sawamura et al, 2016); thus, the animals in this study were weighed weekly to measure how CUMS affected their weights. Some studies have shown an association between depression and food intake (Privitera et al, 2016); therefore, we also recorded the A B C C FIGURE 5 | Effects of chronic unpredictable mild stress (CUMS), Xiaoyaosan, and fluoxetine on the colon tissue mucous membrane appearance and goblet cell morphology.…”

Section: Discussionmentioning

confidence: 99%

“…Weight loss is one of the nine specific symptoms of MDD ( Sawamura et al., 2016 ); thus, the animals in this study were weighed weekly to measure how CUMS affected their weights. Some studies have shown an association between depression and food intake ( Privitera et al., 2016 ); therefore, we also recorded the food intake of the rats weekly to observe the effect of CUMS on appetite.…”

Section: Discussionmentioning

confidence: 99%

Effect of Xiaoyaosan on Colon Morphology and Intestinal Permeability in Rats With Chronic Unpredictable Mild Stress

Ding

Liu

et al. 2020

Front. Pharmacol.

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In our present study, a rat depression model induced by 6 weeks of chronic unpredictable mild stress (CUMS) was established, and we investigated how Xiaoyaosan affects the intestinal permeability of depressed rats and alterations in tight-junction proteins (TJs) involved in this process. Methods: The rat depression model was established using CUMS for 6 consecutive weeks. A total of 40 healthy male Sprague-Dawley rats were randomly sorted into four groups: the control group, CUMS group, Xiaoyaosan group, and fluoxetine group. All groups, excluding the control group, were subjected to the 6-week CUMS program to generate the depression model. Body weight, food intake, and behaviors were observed during the modeling period. Histopathological alterations of colon tissue were evaluated by hematoxylin-eosin staining (H&E), and mucus-containing goblet cells were detected by periodic acid-Schiff (PAS) staining. The ultrastructural morphology of colonic mucosa was observed by transmission electron microscopy. Furthermore, immunohistochemistry (IHC) and quantitative reverse transcription polymerase chain reaction (qRT-PCR) were used to determine the expression of TJs. The concentrations of 5-hydroxytryptamine (5-HT) in the hypothalamus and colon were also assessed using enzyme-linked immunosorbent assay (ELISA). Results: Treatment of depressed rats with Xiaoyaosan alleviated depression-like behaviors as demonstrated by increases in the total distance traveled, the number of entries into the central area in the open field test, the duration spent in the central area, and sucrose preference. Xiaoyaosan treatment also increased body weight gain and food intake in depressed rats. Moreover, Xiaoyaosan treatment effectively improved the colonic pathological and ultrastructural changes, upregulated the expression of ZO-1, occludin, and claudin-1 in the colon, and increased 5-HT levels in the hypothalamus and colonic mucosa.

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“…Reference genome sequences of these grass species were downloaded from Phytozome v12.1 ( https://phytozome.jgi.doe.gov/pz/portal.html ) except for O. thomaeum v2.0, which was downloaded from CoGe ( https://genomevolution.org/coge/ ), and Z. japonica r1.1, which was downloaded from Zoysia Genome Database ( http://zoysia.kazusa.or.jp/index.html ). Sequences of SNV markers were originally stored in the Tags on Physical Map file from the UNEAK pipeline, and were then formatted to the standard FASTA file using python program TagDigger 60 . Alignment was performed with Bowtie2 61 with stringent criteria: -D 20 -R 3 -N 1 -L 18 -i S,1,0.50–local.…”

Section: Methodsmentioning

confidence: 99%

Sequence-based genetic mapping of Cynodon dactylon Pers. reveals new insights into genome evolution in Poaceae

Fang

Dong

et al. 2020

Commun Biol

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Bermudagrass ( Cynodon dactylon Pers.) is an important warm-season perennial used extensively for turf, forage, soil conservation and remediation worldwide. However, limited genomic information has hindered the application of molecular tools towards understanding genome evolution and in breeding new cultivars. We genotype a first-generation selfed population derived from the tetraploid (4x = 36) ‘A12359’ using genotyping-by-sequencing. A high-density genetic map of 18 linkage groups (LGs) is constructed with 3,544 markers. Comparative genomic analyses reveal that each of nine homeologous LG pairs of C. dactylon corresponds to one of the first nine chromosomes of Oropetium thomaeum . Two nested paleo-ancestor chromosome fusions (ρ6-ρ9-ρ6, ρ2-ρ10-ρ2) may have resulted in a 12-to-10 chromosome reduction. A segmental dissemination of the paleo-chromosome ρ12 (ρ1-ρ12-ρ1, ρ6-ρ12-ρ6) leads to the 10-to-9 chromosome reduction in C. dactylon genome. The genetic map will assist in an ongoing whole genome sequence assembly and facilitate marker-assisted selection (MAS) in developing new cultivars.

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Symmetrical treatment of “Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition”, for major depressive disorders

Cited by 9 publications

References 18 publications

The Effect of Early Maternal Separation Combined With Adolescent Chronic Unpredictable Mild Stress on Behavior and Synaptic Plasticity in Adult Female Rats

The Effect of Early Maternal Separation Combined With Adolescent Chronic Unpredictable Mild Stress on Behavior and Synaptic Plasticity in Adult Female Rats

Effect of Xiaoyaosan on Colon Morphology and Intestinal Permeability in Rats With Chronic Unpredictable Mild Stress

Sequence-based genetic mapping of Cynodon dactylon Pers. reveals new insights into genome evolution in Poaceae

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