This paper discusses the application of montmorillonite powder in the treatment of acute small intestinal bleeding. This paper combines the research results at home and abroad to systematically discusses the mechanism, clinical effect, adverse effects and precautions of montmorillonite powder in the treatment of acute small intestinal bleeding. Combined with the domestic and foreign research methods, the domestic research emphasizes its deep research in pharmacology, clinical application and basic research, providing support for its wide application in the domestic medical field. Foreign studies have highlighted that montmorillonite powder not only has unique advantages in the treatment of acute small intestinal bleeding by regulating the balance of intestinal flora and enhancing immunity, but also provides a new therapeutic idea for its combined application with other drugs. Domestic and foreign research progress shows that montmorillonite powder has achieved some efficacy in the treatment of acute small intestinal bleeding, however, despite the significant progress, its mechanism of action and application method still need to be further studied. In the future, multidisciplinary cooperation should be strengthened to develop safer and more effective treatment options through in-depth research to provide more comprehensive medical services for patients with acute small bowel bleeding.