Two-leg bosonic ladders with flux harbor a remarkable vortex-hole duality between the weak-coupling vortex lattice superfluids and strong-coupling charge-density-wave crystals. The strong-coupling crystalline states, which are realized in the vicinity of π flux, are independent of particle statistics, and are related to the incompressible fractional quantum Hall states in the thin-cylinder limit. These fully gapped ground states, away from π flux, develop nonzero chiral (spin) currents. Contact-interacting quantum gases permit exploration of this vortex-hole duality in experiments. DOI: 10.1103/PhysRevLett.119.073401 Dualities encode important nonperturbative information in statistical, condensed matter and high-energy physics, by mapping weak and strong coupling regimes and providing a way for their unified description [1].A quantum system, depending on conditions, can manifest one of its dual natures profoundly. In a weakly coupled gas or liquid, where positions of particles are not fixed, at sufficiently low temperatures quantum effects set in, and, as a result, Bose particles can develop phase coherence and superfluidity. For strong repulsive interparticle interactions, crystals can form, where each particle is localized to a certain position in space to get as far as possible from the others. Phases of particles, being conjugate variables of densities, fluctuate strongly in crystals. Fluids can develop eddy currents, or vortices when excited. In superfluids with global phase coherence, vortices get topological protection by quantization. Crystals also harbour excitations of topological nature-e.g., point defects such as vacancies (holes).The purpose of this Letter is to demonstrate a spectacular correspondence between the topological defects of superfluids and crystals, referred in the following as a vortexhole duality, realized between weak and strong-coupling regimes of bosonic ladders with flux. Figure 1 shows the microscopic configurations of local particle currents (arrows) and densities (filled circles) of a few dual weak and strong-coupling ground states of bosonic ladders with flux. In the weak-coupling limit the phases of particles are the relevant degrees of freedom, whereas in strong-coupling particle densities they play a dominant role. Vortices are indicated by the letter V in those plaquettes of Fig. 1, wherewhere Θ is local phase and integration is along the boundary l of the plaquette □. Holes, defects of the local particle density distribution, are localized on rungs, indicated by the letter H. Vortices (elementary loop currents), topological excitations of a weak-coupling regime, repel each other [2] (like same pole magnets) and vortex lattices (VLs) at a commensurate vortex density ρ V are dual to hole crystals of chargedensity-wave (CDW) states at ρ H ¼ ρ V realized in a strong-coupling regime, as we will show. Table I summarizes the weak and strong-coupling duality relations. In the weak coupling regime of bosonic ladders few VL superfluids were observed [3,4] to survive quantum fluc...