Radiant cooling systems (RCS) are gaining acceptance as a heating, ventilation, and air conditioning (HVAC) solution for achieving adequate thermal comfort and maintaining acceptable indoor air quality inside buildings. RCS are well known for their energy-saving potential; however, serious condensation problem hinders the growth of this technology. In order to prevent the risk of condensation, the supply water temperature is kept higher than the dew point temperature of the air inside the room. The full potential of the cooling power of a radiant cooling panel is limited. Therefore, this article is on maximizing the cooling capacity of a radiant cooling panel, in terms of flow configuration. Radiant cooling panels (RCP) with different chilled water pipe configurations are designed and compared, side by side with the conventional serpentine flow configuration. The cooling performance of the radiant cooling panels is evaluated by using computational fluid dynamics (CFD) with Ansys Fluent software (Ansys 2020 R2, PA, USA). Under similar flow and operating conditions, the common serpentine flow configuration exhibits the least effective cooling performance, with the highest pressure drop across the pipe. It is concluded that the proposed designs have the potential of improving the overall efficiency of RCP in terms of temperature distribution, cooling capacity, and pressure drop.