2014
DOI: 10.1093/icvts/ivu311
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Sympathetic block by metal clips may be a reversible operation

Abstract: Conventional and immunohistochemical stains confirmed that application of metal clips to the sympathetic chain caused severe histological damage in the sympathetic trunk that remained visible 4 weeks after clip removal. However, after 12 weeks, these signs of damage had clearly decreased, which suggests in theory that application of metal clips to the sympathetic chain is a reversible procedure if only the observation period is prolonged. Further studies with longer periods between application and removal as w… Show more

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Cited by 13 publications
(10 citation statements)
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“…Moreover, the upper limit of unclipping time should be defined, because Thomsen et al reported severe histologic nerve damage visible 4 weeks after unclipping of the sympathetic chain in sheep, in which the damage decreased markedly 12 weeks after unclipping. Clips were removed 7 days after they were applied [45][46][47][48]. Studies on animals with unclipping times ranging from a few months to over 1 year after clipping are also necessary to evaluate nerve histology and the reversibility of their function after this period.…”
Section: Discussionmentioning
confidence: 99%
“…Moreover, the upper limit of unclipping time should be defined, because Thomsen et al reported severe histologic nerve damage visible 4 weeks after unclipping of the sympathetic chain in sheep, in which the damage decreased markedly 12 weeks after unclipping. Clips were removed 7 days after they were applied [45][46][47][48]. Studies on animals with unclipping times ranging from a few months to over 1 year after clipping are also necessary to evaluate nerve histology and the reversibility of their function after this period.…”
Section: Discussionmentioning
confidence: 99%
“…However, after 12 weeks, these signs of damage had clearly decreased, which suggests in theory that application of metal clips to the sympathetic chain is a reversible procedure if only the observation period is prolonged. Further studies in humans with longer periods between application and removal as well as investigations of nerve conduction should be encouraged because we do not know whether histological reversibility at cellular level translates into physiological reversibility and possible correlation of nerve trauma with the duration of the applied clip (53).…”
Section: Reversibilitymentioning
confidence: 99%
“…Uncertainty exists about the most useful technique regarding the analgesic satisfaction of the patient on the postoperative period [9]. Surgery depends on the isolation and the dissection of the thoracic sympathetic chain with cauterization and ablation or clipping, the corresponding roots which are responsible for the excessive sweating in certain body areas [10].…”
Section: Introductionmentioning
confidence: 99%